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Items: 1 to 20 of 94


The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.

Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, Arenas E, Carlsson J, Bryja V, Schulte G.

Cell Signal. 2017 Oct;38:85-96. doi: 10.1016/j.cellsig.2017.06.018. Epub 2017 Jun 29.


WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

Arthofer E, Hot B, Petersen J, Strakova K, Jäger S, Grundmann M, Kostenis E, Gutkind JS, Schulte G.

Mol Pharmacol. 2016 Oct;90(4):447-59. doi: 10.1124/mol.116.104919. Epub 2016 Jul 25.


Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G.

FASEB J. 2014 May;28(5):2293-305. doi: 10.1096/fj.13-246363. Epub 2014 Feb 5.


Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.

Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20. doi: 10.1073/pnas.1114802109. Epub 2012 Mar 12.


Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.

Valnohova J, Kowalski-Jahn M, Sunahara RK, Schulte G.

J Biol Chem. 2018 Nov 16;293(46):17875-17887. doi: 10.1074/jbc.RA118.004763. Epub 2018 Sep 20.


FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.

Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhlén M, Kostenis E, Mulder J, Schulte G.

Cell Signal. 2017 Apr;32:93-103. doi: 10.1016/j.cellsig.2017.01.023. Epub 2017 Jan 24.


Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.

Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnos J, Bernatik O, Ganji RS, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte G.

J Biol Chem. 2018 Nov 30;293(48):18477-18493. doi: 10.1074/jbc.RA118.004656. Epub 2018 Oct 11.


Frizzleds as GPCRs - More Conventional Than We Thought!

Schulte G, Wright SC.

Trends Pharmacol Sci. 2018 Sep;39(9):828-842. doi: 10.1016/ Epub 2018 Jul 23. Review.


Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity.

Kilander MB, Dahlström J, Schulte G.

Cell Signal. 2014 Sep;26(9):1943-9. doi: 10.1016/j.cellsig.2014.05.012. Epub 2014 May 27.


The Frizzled family of unconventional G-protein-coupled receptors.

Schulte G, Bryja V.

Trends Pharmacol Sci. 2007 Oct;28(10):518-25. Epub 2007 Sep 19. Review.


β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation.

Seitz K, Dürsch V, Harnoš J, Bryja V, Gentzel M, Schambony A.

PLoS One. 2014 Jan 29;9(1):e87132. doi: 10.1371/journal.pone.0087132. eCollection 2014.


Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.

Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T.

Dev Cell. 2007 Jan;12(1):129-41.


Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

Yu A, Xing Y, Harrison SC, Kirchhausen T.

Structure. 2010 Oct 13;18(10):1311-20. doi: 10.1016/j.str.2010.07.010.


Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.

Gammons MV, Rutherford TJ, Steinhart Z, Angers S, Bienz M.

J Cell Sci. 2016 Oct 15;129(20):3892-3902.


Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.

Dijksterhuis JP, Baljinnyam B, Stanger K, Sercan HO, Ji Y, Andres O, Rubin JS, Hannoush RN, Schulte G.

J Biol Chem. 2015 Mar 13;290(11):6789-98. doi: 10.1074/jbc.M114.612648. Epub 2015 Jan 20.


Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.

Gammons MV, Renko M, Johnson CM, Rutherford TJ, Bienz M.

Mol Cell. 2016 Oct 6;64(1):92-104. doi: 10.1016/j.molcel.2016.08.026. Epub 2016 Sep 29.


WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3.

Dijksterhuis JP, Petersen J, Schulte G.

Br J Pharmacol. 2014 Mar;171(5):1195-209. doi: 10.1111/bph.12364. Review.


Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis.

Romero G, Sneddon WB, Yang Y, Wheeler D, Blair HC, Friedman PA.

J Biol Chem. 2010 May 7;285(19):14756-63. doi: 10.1074/jbc.M110.102970. Epub 2010 Mar 8.


Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.

Qi J, Lee HJ, Saquet A, Cheng XN, Shao M, Zheng JJ, Shi DL.

J Biol Chem. 2017 Apr 7;292(14):5898-5908. doi: 10.1074/jbc.M116.772509. Epub 2017 Feb 21.


WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins.

Bowin CF, Inoue A, Schulte G.

J Biol Chem. 2019 Jun 24. pii: jbc.AC119.009412. doi: 10.1074/jbc.AC119.009412. [Epub ahead of print]

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