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Items: 1 to 20 of 138

1.

Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

Gausachs M, Borras E, Chang K, Gonzalez S, Azuara D, Delgado Amador A, Lopez-Doriga A, San Lucas FA, Sanjuan X, Paules MJ, Taggart MW, Davies GE, Ehli EA, Fowler J, Moreno V, Pineda M, You YN, Lynch PM, Lazaro C, Navin NE, Scheet PA, Hawk ET, Capella G, Vilar E.

Clin Cancer Res. 2017 Oct 1;23(19):5936-5947. doi: 10.1158/1078-0432.CCR-17-0821. Epub 2017 Jun 23.

2.

Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras.

Kawaguchi Y, Hinoi T, Saito Y, Adachi T, Miguchi M, Niitsu H, Sasada T, Shimomura M, Egi H, Oka S, Tanaka S, Chayama K, Sentani K, Oue N, Yasui W, Ohdan H.

J Gastroenterol. 2016 May;51(5):447-57. doi: 10.1007/s00535-015-1121-9. Epub 2015 Sep 11.

PMID:
26361962
3.

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.

Jesinghaus M, Pfarr N, Kloor M, Endris V, Tavernar L, Muckenhuber A, von Knebel Doeberitz M, Penzel R, Weichert W, Stenzinger A.

Genes Chromosomes Cancer. 2016 Mar;55(3):268-77. doi: 10.1002/gcc.22330. Epub 2015 Dec 9.

PMID:
26650777
4.

Three molecular pathways model colorectal carcinogenesis in Lynch syndrome.

Ahadova A, Gallon R, Gebert J, Ballhausen A, Endris V, Kirchner M, Stenzinger A, Burn J, von Knebel Doeberitz M, Bläker H, Kloor M.

Int J Cancer. 2018 Jul 1;143(1):139-150. doi: 10.1002/ijc.31300. Epub 2018 Feb 23.

PMID:
29424427
5.

Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.

Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Mimori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M.

Cancer Res. 2018 Mar 1;78(5):1334-1346. doi: 10.1158/0008-5472.CAN-17-3303. Epub 2017 Dec 27.

6.

Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.

Thirlwell C, Will OC, Domingo E, Graham TA, McDonald SA, Oukrif D, Jeffrey R, Gorman M, Rodriguez-Justo M, Chin-Aleong J, Clark SK, Novelli MR, Jankowski JA, Wright NA, Tomlinson IP, Leedham SJ.

Gastroenterology. 2010 Apr;138(4):1441-54, 1454.e1-7. doi: 10.1053/j.gastro.2010.01.033. Epub 2010 Jan 25.

PMID:
20102718
7.

Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.

Joung JG, Oh BY, Hong HK, Al-Khalidi H, Al-Alem F, Lee HO, Bae JS, Kim J, Cha HU, Alotaibi M, Cho YB, Hassanain M, Park WY, Lee WY.

Clin Cancer Res. 2017 Dec 1;23(23):7209-7216. doi: 10.1158/1078-0432.CCR-17-0306. Epub 2017 Sep 22.

8.

A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer.

Saito T, Niida A, Uchi R, Hirata H, Komatsu H, Sakimura S, Hayashi S, Nambara S, Kuroda Y, Ito S, Eguchi H, Masuda T, Sugimachi K, Tobo T, Nishida H, Daa T, Chiba K, Shiraishi Y, Yoshizato T, Kodama M, Okimoto T, Mizukami K, Ogawa R, Okamoto K, Shuto M, Fukuda K, Matsui Y, Shimamura T, Hasegawa T, Doki Y, Nagayama S, Yamada K, Kato M, Shibata T, Mori M, Aburatani H, Murakami K, Suzuki Y, Ogawa S, Miyano S, Mimori K.

Nat Commun. 2018 Jul 23;9(1):2884. doi: 10.1038/s41467-018-05226-0.

9.

Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.

Takayama T, Ohi M, Hayashi T, Miyanishi K, Nobuoka A, Nakajima T, Satoh T, Takimoto R, Kato J, Sakamaki S, Niitsu Y.

Gastroenterology. 2001 Sep;121(3):599-611.

PMID:
11522744
10.

Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing-based cohort study.

Jauhri M, Bhatnagar A, Gupta S, Bp M, Minhas S, Shokeen Y, Aggarwal S.

Tumour Biol. 2017 Feb;39(2):1010428317692265. doi: 10.1177/1010428317692265.

PMID:
28222664
11.

Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene.

Zauber P, Marotta S, Sabbath-Solitare M.

BMC Cancer. 2016 Mar 12;16:213. doi: 10.1186/s12885-016-2243-z.

12.

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas.

Lim CH, Cho YK, Kim SW, Choi MG, Rhee JK, Chung YJ, Lee SH, Kim TM.

Oncotarget. 2016 Jun 28;7(26):39758-39767. doi: 10.18632/oncotarget.9250.

13.

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.

Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, Muzny D, Sander C, Hamilton SR, Gibbs RA, Wheeler D.

J Pathol. 2013 Jan;229(1):99-110. doi: 10.1002/path.4087.

14.

Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: evaluation of concordance between genomic and transcriptional profiles.

Vignot S, Lefebvre C, Frampton GM, Meurice G, Yelensky R, Palmer G, Capron F, Lazar V, Hannoun L, Miller VA, André F, Stephens PJ, Soria JC, Spano JP.

Eur J Cancer. 2015 May;51(7):791-9. doi: 10.1016/j.ejca.2015.02.012. Epub 2015 Mar 18.

PMID:
25797355
15.

Longitudinal molecular characterization of endoscopic specimens from colorectal lesions.

Minarikova P, Benesova L, Halkova T, Belsanova B, Suchanek S, Cyrany J, Tuckova I, Bures J, Zavoral M, Minarik M.

World J Gastroenterol. 2016 May 28;22(20):4936-45. doi: 10.3748/wjg.v22.i20.4936.

16.

Oxidative DNA damage drives carcinogenesis in MUTYH-associated-polyposis by specific mutations of mitochondrial and MAPK genes.

Venesio T, Balsamo A, Errichiello E, Ranzani GN, Risio M.

Mod Pathol. 2013 Oct;26(10):1371-81. doi: 10.1038/modpathol.2013.66. Epub 2013 Apr 19.

17.

Comprehensive mutation analysis in colorectal flat adenomas.

Voorham QJ, Carvalho B, Spiertz AJ, Claes B, Mongera S, van Grieken NC, Grabsch H, Kliment M, Rembacken B, van de Wiel MA, Quirke P, Mulder CJ, Lambrechts D, van Engeland M, Meijer GA.

PLoS One. 2012;7(7):e41963. doi: 10.1371/journal.pone.0041963. Epub 2012 Jul 27.

18.

Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas.

Grover S, Kastrinos F, Steyerberg EW, Cook EF, Dewanwala A, Burbidge LA, Wenstrup RJ, Syngal S.

JAMA. 2012 Aug 1;308(5):485-492. doi: 10.1001/jama.2012.8780.

19.

DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.

Xu XM, Qian JC, Cai Z, Tang T, Wang P, Zhang KH, Deng ZL, Cai JP.

Eur J Clin Invest. 2012 Jul;42(7):751-9. doi: 10.1111/j.1365-2362.2011.02641.x. Epub 2012 Feb 11.

PMID:
22324744
20.

In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.

Woischke C, Schaaf CW, Yang HM, Vieth M, Veits L, Geddert H, Märkl B, Stömmer P, Schaeffer DF, Frölich M, Blum H, Vosberg S, Greif PA, Jung A, Kirchner T, Horst D.

Mod Pathol. 2017 Jan;30(1):95-103. doi: 10.1038/modpathol.2016.150. Epub 2016 Sep 2.

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