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Bioactive Immune Components of Anti-Diarrheagenic Enterotoxigenic Escherichia coli Hyperimmune Bovine Colostrum Products.

Sears KT, Tennant SM, Reymann MK, Simon R, Konstantopoulos N, Blackwelder WC, Barry EM, Pasetti MF.

Clin Vaccine Immunol. 2017 Aug 4;24(8). pii: e00186-16. doi: 10.1128/CVI.00186-16. Print 2017 Aug.


Maternal vaccination with a fimbrial tip adhesin and passive protection of neonatal mice against lethal human enterotoxigenic Escherichia coli challenge.

Luiz WB, Rodrigues JF, Crabb JH, Savarino SJ, Ferreira LC.

Infect Immun. 2015 Dec;83(12):4555-64. doi: 10.1128/IAI.00858-15. Epub 2015 Sep 14.


Antigen-specific memory B-cell responses to enterotoxigenic Escherichia coli infection in Bangladeshi adults.

Alam MM, Aktar A, Afrin S, Rahman MA, Aktar S, Uddin T, Rahman MA, Al Mahbuba D, Chowdhury F, Khan AI, Bhuiyan TR, Begum YA, Ryan ET, Calderwood SB, Svennerholm AM, Qadri F.

PLoS Negl Trop Dis. 2014 Apr 24;8(4):e2822. doi: 10.1371/journal.pntd.0002822. eCollection 2014 Apr.


Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial.

Savarino SJ, McKenzie R, Tribble DR, Porter CK, O'Dowd A, Cantrell JA, Sincock SA, Poole ST, DeNearing B, Woods CM, Kim H, Grahek SL, Brinkley C, Crabb JH, Bourgeois AL.

J Infect Dis. 2017 Jul 1;216(1):7-13. doi: 10.1093/infdis/jix144.


Current Progress in Developing Subunit Vaccines against Enterotoxigenic Escherichia coli-Associated Diarrhea.

Zhang W, Sack DA.

Clin Vaccine Immunol. 2015 Sep;22(9):983-91. doi: 10.1128/CVI.00224-15. Epub 2015 Jul 1. Review.


Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles after Primary Infection and Homologous Rechallenge with Strain H10407.

Chakraborty S, Harro C, DeNearing B, Ram M, Feller A, Cage A, Bauers N, Bourgeois AL, Walker R, Sack DA.

Clin Vaccine Immunol. 2015 Nov 18;23(1):55-64. doi: 10.1128/CVI.00617-15. Print 2016 Jan.


Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers.

Otto W, Najnigier B, Stelmasiak T, Robins-Browne RM.

Scand J Gastroenterol. 2011 Jul;46(7-8):862-8. doi: 10.3109/00365521.2011.574726.


Protective immunity of a Multivalent Vaccine Candidate against piglet diarrhea caused by enterotoxigenic Escherichia coli (ETEC) in a pig model.

Zhang H, Xu Y, Zhang Z, You J, Yang Y, Li X.

Vaccine. 2018 Jan 29;36(5):723-728. doi: 10.1016/j.vaccine.2017.12.026. Epub 2017 Dec 26.


Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model.

Nandre RM, Duan Q, Wang Y, Zhang W.

Vaccine. 2017 Jan 23;35(4):552-556. doi: 10.1016/j.vaccine.2016.12.021. Epub 2016 Dec 22.


Strategies to overexpress enterotoxigenic Escherichia coli (ETEC) colonization factors for the construction of oral whole-cell inactivated ETEC vaccine candidates.

Tobias J, Svennerholm AM.

Appl Microbiol Biotechnol. 2012 Mar;93(6):2291-300. doi: 10.1007/s00253-012-3930-6. Epub 2012 Feb 16. Review.


Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs.

Takeyama N, Yuki Y, Tokuhara D, Oroku K, Mejima M, Kurokawa S, Kuroda M, Kodama T, Nagai S, Ueda S, Kiyono H.

Vaccine. 2015 Sep 22;33(39):5204-11. doi: 10.1016/j.vaccine.2015.07.074. Epub 2015 Aug 4.


Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein.

Lundgren A, Leach S, Tobias J, Carlin N, Gustafsson B, Jertborn M, Bourgeois L, Walker R, Holmgren J, Svennerholm AM.

Vaccine. 2013 Feb 6;31(8):1163-70. doi: 10.1016/j.vaccine.2012.12.063. Epub 2013 Jan 7.


Hyperimmune bovine colostrum for treatment of GI infections: a review and update on Clostridium difficile.

Steele J, Sponseller J, Schmidt D, Cohen O, Tzipori S.

Hum Vaccin Immunother. 2013 Jul;9(7):1565-8. doi: 10.4161/hv.24078. Epub 2013 Feb 22. Review.


Immunization with the MipA, Skp, or ETEC_2479 Antigens Confers Protection against Enterotoxigenic E. coli Strains Expressing Different Colonization Factors in a Mouse Pulmonary Challenge Model.

Hays MP, Kumar A, Martinez-Becerra FJ, Hardwidge PR.

Front Cell Infect Microbiol. 2016 Dec 12;6:181. doi: 10.3389/fcimb.2016.00181. eCollection 2016.


Immunogenicity of a prototype enterotoxigenic Escherichia coli adhesin vaccine in mice and nonhuman primates.

Sincock SA, Hall ER, Woods CM, O'Dowd A, Poole ST, McVeigh AL, Nunez G, Espinoza N, Miller M, Savarino SJ.

Vaccine. 2016 Jan 4;34(2):284-291. doi: 10.1016/j.vaccine.2015.11.017. Epub 2015 Nov 18.


Serum antibodies protect against intraperitoneal challenge with enterotoxigenic Escherichia coli.

Yang X, Thornburg T, Holderness K, Suo Z, Cao L, Lim T, Avci R, Pascual DW.

J Biomed Biotechnol. 2011;2011:632396. doi: 10.1155/2011/632396. Epub 2011 Oct 9.


Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it.

Mirhoseini A, Amani J, Nazarian S.

Microb Pathog. 2018 Apr;117:162-169. doi: 10.1016/j.micpath.2018.02.032. Epub 2018 Feb 21. Review. Erratum in: Microb Pathog. 2019 Oct;135:103561.


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