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Items: 1 to 20 of 94


The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks.

Ivan M, Kaelin WG Jr.

Mol Cell. 2017 Jun 15;66(6):772-779. doi: 10.1016/j.molcel.2017.06.002. Review.


A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery.

Alcaide-German ML, Vara-Vega A, Garcia-Fernandez LF, Landazuri MO, del Peso L.

BMC Cell Biol. 2008 Apr 10;9:18. doi: 10.1186/1471-2121-9-18.


A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis.

Joshi S, Singh AR, Zulcic M, Durden DL.

Mol Cancer Res. 2014 Oct;12(10):1520-31. doi: 10.1158/1541-7786.MCR-13-0682. Epub 2014 Aug 7.


Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways.

Rohwer N, Cramer T.

Drug Resist Updat. 2011 Jun;14(3):191-201. doi: 10.1016/j.drup.2011.03.001. Epub 2011 Apr 3. Review.


HIF prolyl-4-hydroxylase interacting proteins: consequences for drug targeting.

Wenger RH, Camenisch G, Stiehl DP, Katschinski DM.

Curr Pharm Des. 2009;15(33):3886-94. Review.


Targeting the hypoxia-sensing pathway in clinical hematology.

Forristal CE, Levesque JP.

Stem Cells Transl Med. 2014 Feb;3(2):135-40. doi: 10.5966/sctm.2013-0134. Epub 2013 Dec 26.


Role and regulation of prolyl hydroxylase domain proteins.

Fong GH, Takeda K.

Cell Death Differ. 2008 Apr;15(4):635-41. doi: 10.1038/cdd.2008.10. Epub 2008 Feb 15. Review.


Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia.

Bagnall J, Leedale J, Taylor SE, Spiller DG, White MR, Sharkey KJ, Bearon RN, Sée V.

J Biol Chem. 2014 Feb 28;289(9):5549-64. doi: 10.1074/jbc.M113.500405. Epub 2014 Jan 6.


Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases.

Kaelin WG Jr.

Cold Spring Harb Symp Quant Biol. 2011;76:335-45. doi: 10.1101/sqb.2011.76.010975. Epub 2011 Nov 16. Review.


The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road.

Günter J, Ruiz-Serrano A, Pickel C, Wenger RH, Scholz CC.

Exp Cell Res. 2017 Jul 15;356(2):152-159. doi: 10.1016/j.yexcr.2017.03.027. Epub 2017 Mar 15. Review.


Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis.

Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1788-96. doi: 10.1073/pnas.1305961110. Epub 2013 Apr 22.


Hypoxia-inducible factors and the response to hypoxic stress.

Majmundar AJ, Wong WJ, Simon MC.

Mol Cell. 2010 Oct 22;40(2):294-309. doi: 10.1016/j.molcel.2010.09.022. Review.


A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.

Mysore VS, Szablowski J, Dervan PB, Frost PJ.

Mol Cancer Res. 2016 Mar;14(3):253-66. doi: 10.1158/1541-7786.MCR-15-0361. Epub 2016 Jan 22.


Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes.

Wong BW, Kuchnio A, Bruning U, Carmeliet P.

Trends Biochem Sci. 2013 Jan;38(1):3-11. doi: 10.1016/j.tibs.2012.10.004. Epub 2012 Nov 28. Review.


The role of hypoxia-inducible factors in tumorigenesis.

Rankin EB, Giaccia AJ.

Cell Death Differ. 2008 Apr;15(4):678-85. doi: 10.1038/cdd.2008.21. Epub 2008 Feb 15. Review.


Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α.

Schöning JP, Monteiro M, Gu W.

Clin Exp Pharmacol Physiol. 2017 Feb;44(2):153-161. doi: 10.1111/1440-1681.12693. Review.


Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.

Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T.

Cancer Res. 2010 Jan 1;70(1):357-66. doi: 10.1158/0008-5472.CAN-09-1876. Epub 2009 Dec 22.


HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.

Smeyne M, Sladen P, Jiao Y, Dragatsis I, Smeyne RJ.

Neuroscience. 2015 Jun 4;295:23-38. doi: 10.1016/j.neuroscience.2015.03.015. Epub 2015 Mar 19.


Hypoxia-inducible factor α subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent.

Ryu JH, Li SH, Park HS, Park JW, Lee B, Chun YS.

J Biol Chem. 2011 Mar 4;286(9):6963-70. doi: 10.1074/jbc.M110.188706. Epub 2010 Dec 30.

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