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Items: 1 to 20 of 178

1.

Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.

Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Sato N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Nakanishi Y, Kuwano K.

Autophagy. 2017 Aug 3;13(8):1420-1434. doi: 10.1080/15548627.2017.1328348. Epub 2017 Jun 14.

2.

Metformin attenuates lung fibrosis development via NOX4 suppression.

Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, Saito N, Fujita Y, Kurita Y, Kobayashi K, Ito S, Hara H, Kadota T, Yanagisawa H, Hashimoto M, Utsumi H, Wakui H, Kojima J, Numata T, Kaneko Y, Odaka M, Morikawa T, Nakayama K, Kohrogi H, Kuwano K.

Respir Res. 2016 Aug 30;17(1):107. doi: 10.1186/s12931-016-0420-x.

3.

Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy.

Kurita Y, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Tsubouchi K, Sato N, Yoshida M, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K.

Respir Res. 2017 Jun 2;18(1):114. doi: 10.1186/s12931-017-0600-3.

4.

Transforming growth factor β1 (TGFβ1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis.

Ghatak S, Hascall VC, Markwald RR, Feghali-Bostwick C, Artlett CM, Gooz M, Bogatkevich GS, Atanelishvili I, Silver RM, Wood J, Thannickal VJ, Misra S.

J Biol Chem. 2017 Jun 23;292(25):10490-10519. doi: 10.1074/jbc.M116.752469. Epub 2017 Apr 7.

5.
6.

Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.

Huang LS, Jiang P, Feghali-Bostwick C, Reddy SP, Garcia JGN, Natarajan V.

Free Radic Biol Med. 2017 Nov;112:162-173. doi: 10.1016/j.freeradbiomed.2017.07.023. Epub 2017 Jul 24.

PMID:
28751023
7.

TGF-β1 stimulates HDAC4 nucleus-to-cytoplasm translocation and NADPH oxidase 4-derived reactive oxygen species in normal human lung fibroblasts.

Guo W, Saito S, Sanchez CG, Zhuang Y, Gongora Rosero RE, Shan B, Luo F, Lasky JA.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L936-L944. doi: 10.1152/ajplung.00256.2016. Epub 2017 Mar 23.

8.

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation.

Stock CJW, Michaeloudes C, Leoni P, Durham AL, Mumby S, Wells AU, Chung KF, Adcock IM, Renzoni EA, Lindahl GE.

Biomed Res Int. 2019 Apr 18;2019:1484736. doi: 10.1155/2019/1484736. eCollection 2019.

9.

Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.

Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, Sato N, Yoshida M, Tsubouchi K, Kurita Y, Ito S, Fujita Y, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K.

J Immunol. 2016 Jul 15;197(2):504-16. doi: 10.4049/jimmunol.1600265. Epub 2016 Jun 8.

10.

Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.

Desai LP, Zhou Y, Estrada AV, Ding Q, Cheng G, Collawn JF, Thannickal VJ.

J Biol Chem. 2014 Jun 27;289(26):18270-8. doi: 10.1074/jbc.M114.562249. Epub 2014 May 15.

11.

miR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2.

Fierro-Fernández M, Busnadiego Ó, Sandoval P, Espinosa-Díez C, Blanco-Ruiz E, Rodríguez M, Pian H, Ramos R, López-Cabrera M, García-Bermejo ML, Lamas S.

EMBO Rep. 2015 Oct;16(10):1358-77. doi: 10.15252/embr.201540750. Epub 2015 Aug 27.

12.

An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model.

Jarman ER, Khambata VS, Cope C, Jones P, Roger J, Ye LY, Duggan N, Head D, Pearce A, Press NJ, Bellenie B, Sohal B, Jarai G.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):158-69. doi: 10.1165/rcmb.2013-0174OC.

PMID:
23977848
13.

RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.

Manickam N, Patel M, Griendling KK, Gorin Y, Barnes JL.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F159-71. doi: 10.1152/ajprenal.00546.2013. Epub 2014 May 28.

14.

Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo.

Luo F, Zhuang Y, Sides MD, Sanchez CG, Shan B, White ES, Lasky JA.

Respir Res. 2014 Apr 24;15:51. doi: 10.1186/1465-9921-15-51.

15.

Regulation of 26S Proteasome Activity in Pulmonary Fibrosis.

Semren N, Welk V, Korfei M, Keller IE, Fernandez IE, Adler H, Günther A, Eickelberg O, Meiners S.

Am J Respir Crit Care Med. 2015 Nov 1;192(9):1089-101. doi: 10.1164/rccm.201412-2270OC.

PMID:
26207697
16.

CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling.

Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, Yu F, Wang X, Zhou J, Kong W.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1698-1709. doi: 10.1161/ATVBAHA.117.309859. Epub 2017 Jul 27.

PMID:
28751569
17.

Transforming growth factor β1-induced collagen production in myofibroblasts is mediated by reactive oxygen species derived from NADPH oxidase 4.

Hotta Y, Uchiyama K, Takagi T, Kashiwagi S, Nakano T, Mukai R, Toyokawa Y, Yasuda T, Ueda T, Suyama Y, Murakami T, Tanaka M, Majima A, Doi T, Hirai Y, Mizushima K, Morita M, Higashimura Y, Inoue K, Fukui A, Okayama T, Katada K, Kamada K, Handa O, Ishikawa T, Naito Y, Itoh Y.

Biochem Biophys Res Commun. 2018 Nov 30;506(3):557-562. doi: 10.1016/j.bbrc.2018.10.116. Epub 2018 Oct 23.

PMID:
30361098
18.

Heat Shock Protein 70 and CHIP Promote Nox4 Ubiquitination and Degradation within the Losartan Antioxidative Effect in Proximal Tubule Cells.

Gil Lorenzo AF, Costantino VV, Appiolaza ML, Cacciamani V, Benardon ME, Bocanegra V, Vallés PG.

Cell Physiol Biochem. 2015;36(6):2183-97. doi: 10.1159/000430184. Epub 2015 Jul 24.

19.

The small heat-shock protein αB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis.

Bellaye PS, Wettstein G, Burgy O, Besnard V, Joannes A, Colas J, Causse S, Marchal-Somme J, Fabre A, Crestani B, Kolb M, Gauldie J, Camus P, Garrido C, Bonniaud P.

J Pathol. 2014 Mar;232(4):458-72. doi: 10.1002/path.4314.

PMID:
24307592
20.

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.

Oruqaj G, Karnati S, Vijayan V, Kotarkonda LK, Boateng E, Zhang W, Ruppert C, Günther A, Shi W, Baumgart-Vogt E.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2048-57. doi: 10.1073/pnas.1415111112. Epub 2015 Apr 6.

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