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Items: 1 to 20 of 203

1.

Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice.

Wu Z, Ni J, Liu Y, Teeling JL, Takayama F, Collcutt A, Ibbett P, Nakanishi H.

Brain Behav Immun. 2017 Oct;65:350-361. doi: 10.1016/j.bbi.2017.06.002. Epub 2017 Jun 10.

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3.

The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.

Ni J, Wu Z, Peterts C, Yamamoto K, Qing H, Nakanishi H.

J Neurosci. 2015 Sep 9;35(36):12488-501. doi: 10.1523/JNEUROSCI.1599-15.2015.

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Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model.

Hoeijmakers L, Ruigrok SR, Amelianchik A, Ivan D, van Dam AM, Lucassen PJ, Korosi A.

Brain Behav Immun. 2017 Jul;63:160-175. doi: 10.1016/j.bbi.2016.12.023. Epub 2016 Dec 25.

PMID:
28027926
6.

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L.

Neuron. 2006 Sep 21;51(6):703-14.

7.

Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.

Wang C, Sun B, Zhou Y, Grubb A, Gan L.

J Biol Chem. 2012 Nov 16;287(47):39834-41. doi: 10.1074/jbc.M112.371641. Epub 2012 Sep 28.

8.

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice.

Ilievski V, Zuchowska PK, Green SJ, Toth PT, Ragozzino ME, Le K, Aljewari HW, O'Brien-Simpson NM, Reynolds EC, Watanabe K.

PLoS One. 2018 Oct 3;13(10):e0204941. doi: 10.1371/journal.pone.0204941. eCollection 2018.

9.

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease.

Embury CM, Dyavarshetty B, Lu Y, Wiederin JL, Ciborowski P, Gendelman HE, Kiyota T.

J Neuroimmune Pharmacol. 2017 Jun;12(2):340-352. doi: 10.1007/s11481-016-9721-6. Epub 2016 Dec 13.

10.

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF-κB Activation.

Li X, Wu Z, Ni J, Liu Y, Meng J, Yu W, Nakanishi H, Zhou Y.

Oxid Med Cell Longev. 2016;2016:7894247. doi: 10.1155/2016/7894247. Epub 2016 Aug 28.

11.

SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer's disease.

Brunner D, Flunkert S, Neddens J, Duller S, Scopes DIC, Treherne JM, Hutter-Paier B.

Neurosci Lett. 2017 Nov 1;660:96-102. doi: 10.1016/j.neulet.2017.09.028. Epub 2017 Sep 14.

PMID:
28917978
12.

Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer's disease model.

Liu YL, Chen WT, Lin YY, Lu PH, Hsieh SL, Cheng IH.

Mol Neurodegener. 2017 Apr 24;12(1):30. doi: 10.1186/s13024-017-0173-0.

13.

Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.

Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, Nakanishi H.

J Neurosci. 2012 Aug 15;32(33):11330-42.

14.

Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia.

Wu Z, Sun L, Hashioka S, Yu S, Schwab C, Okada R, Hayashi Y, McGeer PL, Nakanishi H.

Neurobiol Aging. 2013 Dec;34(12):2715-25. doi: 10.1016/j.neurobiolaging.2013.05.018. Epub 2013 Jul 4.

PMID:
23831373
15.

1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice.

Jeong YJ, Kang GY, Kwon JH, Choi HD, Pack JK, Kim N, Lee YS, Lee HJ.

Curr Alzheimer Res. 2015;12(5):481-92.

16.

Methyl jasmonate attenuates memory dysfunction and decreases brain levels of biomarkers of neuroinflammation induced by lipopolysaccharide in mice.

Solomon U, Taghogho EA.

Brain Res Bull. 2017 May;131:133-141. doi: 10.1016/j.brainresbull.2017.04.002. Epub 2017 Apr 12.

PMID:
28411132
17.

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation.

Cherry JD, Olschowka JA, O'Banion MK.

J Neuroinflammation. 2015 Nov 4;12:203. doi: 10.1186/s12974-015-0411-8.

18.

Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis.

Dekita M, Wu Z, Ni J, Zhang X, Liu Y, Yan X, Nakanishi H, Takahashi I.

Front Pharmacol. 2017 Jul 17;8:470. doi: 10.3389/fphar.2017.00470. eCollection 2017.

19.

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.

Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA.

J Neurosci. 2008 Jun 18;28(25):6333-41. doi: 10.1523/JNEUROSCI.0829-08.2008.

20.

Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models.

Lonskaya I, Hebron ML, Selby ST, Turner RS, Moussa CE.

Neuroscience. 2015 Sep 24;304:316-27. doi: 10.1016/j.neuroscience.2015.07.070. Epub 2015 Jul 30.

PMID:
26235435

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