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Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M.

Nat Immunol. 2017 Aug;18(8):899-910. doi: 10.1038/ni.3767. Epub 2017 Jun 12.


Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.

Ohshima J, Lee Y, Sasai M, Saitoh T, Su Ma J, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M.

J Immunol. 2014 Apr 1;192(7):3328-35. doi: 10.4049/jimmunol.1302822. Epub 2014 Feb 21.


Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy.

Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S.

Autophagy. 2016 Jul 2;12(7):1153-67. doi: 10.1080/15548627.2016.1178447. Epub 2016 May 12.


Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.

Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S.

Cell Host Microbe. 2017 Jul 12;22(1):74-85.e7. doi: 10.1016/j.chom.2017.06.005. Epub 2017 Jun 29.


Autophagosome formation and cargo sequestration in the absence of LC3/GABARAPs.

Padman BS, Nguyen TN, Lazarou M.

Autophagy. 2017 Apr 3;13(4):772-774. doi: 10.1080/15548627.2017.1281492. Epub 2017 Feb 6.


The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S, Virgin HW.

Immunity. 2014 Jun 19;40(6):924-35. doi: 10.1016/j.immuni.2014.05.006. Epub 2014 Jun 12.


RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4581-90. doi: 10.1073/pnas.1510031112. Epub 2015 Aug 3.


Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth.

Wang Y, Weiss LM, Orlofsky A.

J Biol Chem. 2009 Jan 16;284(3):1694-701. doi: 10.1074/jbc.M807890200. Epub 2008 Nov 21.


Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy.

Choi J, Biering SB, Hwang S.

Small GTPases. 2017 Oct 2;8(4):199-207. doi: 10.1080/21541248.2016.1213090. Epub 2016 Jul 18. Review.


A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.

Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DC, Soldati-Favre D, Horie K, Takeda J, Takeda K.

Immunity. 2012 Aug 24;37(2):302-13. Epub 2012 Jul 12.


Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.

Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW.

Cell Host Microbe. 2008 Nov 13;4(5):458-69. doi: 10.1016/j.chom.2008.10.003.


Autophagy and checkpoints for intracellular pathogen defense.

Paulus GL, Xavier RJ.

Curr Opin Gastroenterol. 2015 Jan;31(1):14-23. doi: 10.1097/MOG.0000000000000134. Review.


A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.

Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD.

MBio. 2015 Sep 8;6(5):e01157-15. doi: 10.1128/mBio.01157-15.


The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.

Haldar AK, Piro AS, Pilla DM, Yamamoto M, Coers J.

PLoS One. 2014 Jan 17;9(1):e86684. doi: 10.1371/journal.pone.0086684. eCollection 2014.


Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death.

Zhao YO, Khaminets A, Hunn JP, Howard JC.

PLoS Pathog. 2009 Feb;5(2):e1000288. doi: 10.1371/journal.ppat.1000288. Epub 2009 Feb 6.


p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen.

Lee Y, Sasai M, Ma JS, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, Yamamoto M.

Cell Rep. 2015 Oct 13;13(2):223-33. doi: 10.1016/j.celrep.2015.09.005. Epub 2015 Oct 1.


Autophagic elimination of intracellular parasites: convergent induction by IFN-gamma and CD40 ligation?

Yap GS, Ling Y, Zhao Y.

Autophagy. 2007 Mar-Apr;3(2):163-5. Epub 2007 Mar 5.


K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells.

Clough B, Wright JD, Pereira PM, Hirst EM, Johnston AC, Henriques R, Frickel EM.

PLoS Pathog. 2016 Nov 22;12(11):e1006027. doi: 10.1371/journal.ppat.1006027. eCollection 2016 Nov.


The immune system GTPase GIMAP6 interacts with the Atg8 homologue GABARAPL2 and is recruited to autophagosomes.

Pascall JC, Rotondo S, Mukadam AS, Oxley D, Webster J, Walker SA, Piron J, Carter C, Ktistakis NT, Butcher GW.

PLoS One. 2013 Oct 17;8(10):e77782. doi: 10.1371/journal.pone.0077782. eCollection 2013.

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