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A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle.

Matschulla T, Berry R, Gerke C, Döring M, Busch J, Paijo J, Kalinke U, Momburg F, Hengel H, Halenius A.

Sci Rep. 2017 Jun 7;7(1):2933. doi: 10.1038/s41598-017-02994-5.


Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R.

EMBO J. 1996 Jul 1;15(13):3247-55.


Structure of the viral TAP-inhibitor ICP47 induced by membrane association.

Beinert D, Neumann L, Uebel S, Tampé R.

Biochemistry. 1997 Apr 15;36(15):4694-700.


A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter.

Oldham ML, Hite RK, Steffen AM, Damko E, Li Z, Walz T, Chen J.

Nature. 2016 Jan 28;529(7587):537-40. doi: 10.1038/nature16506. Epub 2016 Jan 20.


Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.

Tomazin R, Hill AB, Jugovic P, York I, van Endert P, Ploegh HL, Andrews DW, Johnson DC.

EMBO J. 1996 Jul 1;15(13):3256-66.


A dual inhibition mechanism of herpesviral ICP47 arresting a conformationally thermostable TAP complex.

Herbring V, Bäucker A, Trowitzsch S, Tampé R.

Sci Rep. 2016 Nov 15;6:36907. doi: 10.1038/srep36907.


Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP.

Tomazin R, van Schoot NE, Goldsmith K, Jugovic P, Sempé P, Früh K, Johnson DC.

J Virol. 1998 Mar;72(3):2560-3.


Characterization of porcine TAP genes: alternative splicing of TAP1.

García-Borges CN, Phanavanh B, Crew MD.

Immunogenetics. 2006 Jun;58(5-6):374-82. Epub 2006 Mar 23.


The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJ, Ploegh HL, Peterson PA, Yang Y, Früh K.

Immunity. 1997 May;6(5):613-21.


Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy.

Pfänder R, Neumann L, Zweckstetter M, Seger C, Holak TA, Tampé R.

Biochemistry. 1999 Oct 12;38(41):13692-8.


Structure of the transporter associated with antigen processing trapped by herpes simplex virus.

Oldham ML, Grigorieff N, Chen J.

Elife. 2016 Dec 9;5. pii: e21829. doi: 10.7554/eLife.21829.


Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing.

Halenius A, Momburg F, Reinhard H, Bauer D, Lobigs M, Hengel H.

J Biol Chem. 2006 Mar 3;281(9):5383-90. Epub 2005 Dec 15.


Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing.

Chen M, Abele R, Tampé R.

J Biol Chem. 2003 Aug 8;278(32):29686-92. Epub 2003 May 30.


Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses.

Verweij MC, Ressing ME, Knetsch W, Quinten E, Halenius A, van Bel N, Hengel H, Drijfhout JW, van Hall T, Wiertz EJ.

Mol Immunol. 2011 Mar;48(6-7):835-45. doi: 10.1016/j.molimm.2010.12.008. Epub 2011 Feb 2.


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