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Items: 1 to 20 of 92

1.

Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.

Iwatani-Yoshihara M, Ito M, Klein MG, Yamamoto T, Yonemori K, Tanaka T, Miwa M, Morishita D, Endo S, Tjhen R, Qin L, Nakanishi A, Maezaki H, Kawamoto T.

J Med Chem. 2017 Jul 13;60(13):5759-5771. doi: 10.1021/acs.jmedchem.7b00461. Epub 2017 Jun 20.

PMID:
28586220
2.

Discovery of spiro[indole-3,2'-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP.

Ito M, Iwatani M, Yamamoto T, Tanaka T, Kawamoto T, Morishita D, Nakanishi A, Maezaki H.

Bioorg Med Chem. 2017 Sep 1;25(17):4753-4767. doi: 10.1016/j.bmc.2017.07.017. Epub 2017 Jul 13.

PMID:
28751196
3.

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.

Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Preussner M, Heyd F, Urlaub H, Lührmann R, Santos KF, Wahl MC.

Genes Dev. 2015 Dec 15;29(24):2576-87. doi: 10.1101/gad.271528.115. Epub 2015 Dec 4.

4.

Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.

Absmeier E, Becke C, Wollenhaupt J, Santos KF, Wahl MC.

Cell Cycle. 2017 Jan 2;16(1):100-112. doi: 10.1080/15384101.2016.1255384. Epub 2016 Nov 23.

5.

Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.

Zhang L, Li X, Hill RC, Qiu Y, Zhang W, Hansen KC, Zhao R.

Nucleic Acids Res. 2015 Mar 31;43(6):3286-97. doi: 10.1093/nar/gkv062. Epub 2015 Feb 10.

6.

Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.

Pena V, Jovin SM, Fabrizio P, Orlowski J, Bujnicki JM, Lührmann R, Wahl MC.

Mol Cell. 2009 Aug 28;35(4):454-66. doi: 10.1016/j.molcel.2009.08.006. Erratum in: Mol Cell. 2011 Feb 4;41(3):366.

7.

Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity.

Ledoux S, Guthrie C.

J Biol Chem. 2016 Jun 3;291(23):11954-65. doi: 10.1074/jbc.M115.710848. Epub 2016 Apr 12.

8.

Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.

Theuser M, Höbartner C, Wahl MC, Santos KF.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7798-803. doi: 10.1073/pnas.1524616113. Epub 2016 Jun 27.

9.

Functions and regulation of the Brr2 RNA helicase during splicing.

Absmeier E, Santos KF, Wahl MC.

Cell Cycle. 2016 Dec 16;15(24):3362-3377. doi: 10.1080/15384101.2016.1249549. Epub 2016 Oct 28. Review.

10.

A new role for FBP21 as regulator of Brr2 helicase activity.

Henning LM, Santos KF, Sticht J, Jehle S, Lee CT, Wittwer M, Urlaub H, Stelzl U, Wahl MC, Freund C.

Nucleic Acids Res. 2017 Jul 27;45(13):7922-7937. doi: 10.1093/nar/gkx535.

11.

A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.

Absmeier E, Rosenberger L, Apelt L, Becke C, Santos KF, Stelzl U, Wahl MC.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):762-71. doi: 10.1107/S1399004715001005. Epub 2015 Mar 26.

PMID:
25849387
12.

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.

Mozaffari-Jovin S, Santos KF, Hsiao HH, Will CL, Urlaub H, Wahl MC, Lührmann R.

Genes Dev. 2012 Nov 1;26(21):2422-34. doi: 10.1101/gad.200949.112.

13.

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2.

Zhang L, Xu T, Maeder C, Bud LO, Shanks J, Nix J, Guthrie C, Pleiss JA, Zhao R.

Nat Struct Mol Biol. 2009 Jul;16(7):731-9. doi: 10.1038/nsmb.1625. Epub 2009 Jun 14.

14.

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.

Santos KF, Jovin SM, Weber G, Pena V, Lührmann R, Wahl MC.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17418-23. doi: 10.1073/pnas.1208098109. Epub 2012 Oct 8.

15.

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.

Mozaffari-Jovin S, Wandersleben T, Santos KF, Will CL, Lührmann R, Wahl MC.

Science. 2013 Jul 5;341(6141):80-4. doi: 10.1126/science.1237515. Epub 2013 May 23.

16.

Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2.

Wollenhaupt J, Henning LM, Sticht J, Becke C, Freund C, Santos KF, Wahl MC.

Biophys J. 2018 Feb 27;114(4):788-799. doi: 10.1016/j.bpj.2017.12.033.

17.

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.

Maeder C, Kutach AK, Guthrie C.

Nat Struct Mol Biol. 2009 Jan;16(1):42-8. doi: 10.1038/nsmb.1535. Epub 2008 Dec 21.

18.
19.

Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum.

Tauchert MJ, Ficner R.

Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):409-16. doi: 10.1107/S2053230X16006038. Epub 2016 Apr 22.

20.

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

Nguyen TH, Galej WP, Bai XC, Savva CG, Newman AJ, Scheres SH, Nagai K.

Nature. 2015 Jul 2;523(7558):47-52. doi: 10.1038/nature14548. Epub 2015 Jun 24.

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