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Items: 1 to 20 of 105

1.

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.

Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW.

Sci Transl Med. 2017 May 31;9(392). pii: eaal3447. doi: 10.1126/scitranslmed.aal3447.

2.

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.

Yarwood RE, Imlach WL, Lieu T, Veldhuis NA, Jensen DD, Klein Herenbrink C, Aurelio L, Cai Z, Christie MJ, Poole DP, Porter CJH, McLean P, Hicks GA, Geppetti P, Halls ML, Canals M, Bunnett NW.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12309-12314. doi: 10.1073/pnas.1706656114. Epub 2017 Oct 30.

3.

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones.

Pelayo JC, Poole DP, Steinhoff M, Cottrell GS, Bunnett NW.

J Physiol. 2011 Nov 1;589(Pt 21):5213-30. doi: 10.1113/jphysiol.2011.214452. Epub 2011 Aug 30.

4.

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.

Jensen DD, Halls ML, Murphy JE, Canals M, Cattaruzza F, Poole DP, Lieu T, Koon HW, Pothoulakis C, Bunnett NW.

J Biol Chem. 2014 Jul 18;289(29):20283-94. doi: 10.1074/jbc.M114.578179. Epub 2014 Jun 4.

5.

Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases.

Roosterman D, Cottrell GS, Schmidlin F, Steinhoff M, Bunnett NW.

J Biol Chem. 2004 Jul 16;279(29):30670-9. Epub 2004 May 5.

6.

Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor.

Schmidlin F, Dery O, DeFea KO, Slice L, Patierno S, Sternini C, Grady EF, Bunnett NW.

J Biol Chem. 2001 Jul 6;276(27):25427-37. Epub 2001 Apr 16.

7.

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system.

Poole DP, Lieu T, Pelayo JC, Eriksson EM, Veldhuis NA, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 15;309(4):G248-59. doi: 10.1152/ajpgi.00118.2015. Epub 2015 Jul 2.

8.
9.

Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor.

McConalogue K, Déry O, Lovett M, Wong H, Walsh JH, Grady EF, Bunnett NW.

J Biol Chem. 1999 Jun 4;274(23):16257-68.

10.

Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling.

Roosterman D, Cottrell GS, Padilla BE, Muller L, Eckman CB, Bunnett NW, Steinhoff M.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11838-43. Epub 2007 Jun 25.

11.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16.

PMID:
30012612
12.

Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.

Pal K, Mathur M, Kumar P, DeFea K.

J Biol Chem. 2013 Feb 1;288(5):3265-74. doi: 10.1074/jbc.M112.400234. Epub 2012 Dec 12.

13.

Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord.

Zhang MM, Ji W, Pei LY, Wang W, Chen T, Wang W, Li H, Zhang T, Wu SX, Li YQ.

PLoS One. 2013;8(3):e59234. doi: 10.1371/journal.pone.0059234. Epub 2013 Mar 21.

14.

Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons.

Taylor BK, Fu W, Kuphal KE, Stiller CO, Winter MK, Chen W, Corder GF, Urban JH, McCarson KE, Marvizon JC.

Neuroscience. 2014 Jan 3;256:178-94. doi: 10.1016/j.neuroscience.2013.10.054. Epub 2013 Oct 31.

15.
16.

Mechanisms of initiation and termination of signalling by neuropeptide receptors: a comparison with the proteinase-activated receptors.

Defea K, Schmidlin F, Déry O, Grady EF, Bunnett NW.

Biochem Soc Trans. 2000;28(4):419-26.

PMID:
10961932
17.

Regulated norepinephrine transporter interaction with the neurokinin-1 receptor establishes transporter subcellular localization.

Arapulisamy O, Mannangatti P, Jayanthi LD.

J Biol Chem. 2013 Oct 4;288(40):28599-610. doi: 10.1074/jbc.M113.472878. Epub 2013 Aug 26.

18.

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU.

J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1.

19.

Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo.

Berger M, Neth O, Ilmer M, Garnier A, Salinas-Martín MV, de Agustín Asencio JC, von Schweinitz D, Kappler R, Muñoz M.

J Hepatol. 2014 May;60(5):985-94. doi: 10.1016/j.jhep.2013.12.024. Epub 2014 Jan 8.

PMID:
24412605
20.

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE.

Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2622-6.

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