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Items: 1 to 20 of 74

1.

Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling.

Tripodo C, Burocchi A, Piccaluga PP, Chiodoni C, Portararo P, Cappetti B, Botti L, Gulino A, Isidori A, Liso A, Visani G, Martelli MP, Falini B, Pandolfi PP, Colombo MP, Sangaletti S.

Cancer Res. 2017 Jul 1;77(13):3685-3699. doi: 10.1158/0008-5472.CAN-17-1098. Epub 2017 May 23.

2.

A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.

Chou SH, Ko BS, Chiou JS, Hsu YC, Tsai MH, Chiu YC, Yu IS, Lin SW, Hou HA, Kuo YY, Lin HM, Wu MF, Chou WC, Tien HF.

PLoS One. 2012;7(11):e49769. doi: 10.1371/journal.pone.0049769. Epub 2012 Nov 30.

3.

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.

Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, Salomonis N, Figueroa ME, Grimes HL.

Cancer Discov. 2016 May;6(5):501-15. doi: 10.1158/2159-8290.CD-16-0008. Epub 2016 Mar 25.

4.

Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion.

Tripodo C, Sangaletti S, Guarnotta C, Piccaluga PP, Cacciatore M, Giuliano M, Franco G, Chiodoni C, Sciandra M, Miotti S, Calvaruso G, Carè A, Florena AM, Scotlandi K, Orazi A, Pileri SA, Colombo MP.

Blood. 2012 Oct 25;120(17):3541-54. doi: 10.1182/blood-2011-12-398537. Epub 2012 Sep 5.

PMID:
22955913
5.

Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor.

Manshouri T, Estrov Z, Quintás-Cardama A, Burger J, Zhang Y, Livun A, Knez L, Harris D, Creighton CJ, Kantarjian HM, Verstovsek S.

Cancer Res. 2011 Jun 1;71(11):3831-40. doi: 10.1158/0008-5472.CAN-10-4002. Epub 2011 Apr 21.

6.

Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice.

MacKenzie KL, Dolnikov A, Millington M, Shounan Y, Symonds G.

Blood. 1999 Mar 15;93(6):2043-56.

PMID:
10068678
7.

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.

Pear WS, Miller JP, Xu L, Pui JC, Soffer B, Quackenbush RC, Pendergast AM, Bronson R, Aster JC, Scott ML, Baltimore D.

Blood. 1998 Nov 15;92(10):3780-92.

PMID:
9808572
8.

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.

Chan IT, Kutok JL, Williams IR, Cohen S, Kelly L, Shigematsu H, Johnson L, Akashi K, Tuveson DA, Jacks T, Gilliland DG.

J Clin Invest. 2004 Feb;113(4):528-38.

9.

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

Porse BT, Bryder D, Theilgaard-Mönch K, Hasemann MS, Anderson K, Damgaard I, Jacobsen SE, Nerlov C.

J Exp Med. 2005 Jul 4;202(1):85-96. Epub 2005 Jun 27.

10.
11.

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.

Cheng K, Sportoletti P, Ito K, Clohessy JG, Teruya-Feldstein J, Kutok JL, Pandolfi PP.

Blood. 2010 Apr 22;115(16):3341-5. doi: 10.1182/blood-2009-03-208587. Epub 2009 Aug 7.

12.

The bone marrow stem stromal imbalance--a key feature of disease progression in case of myelodysplastic mouse model.

Das M, Chatterjee S, Basak P, Das P, Pereira JA, Dutta RK, Chaklader M, Chaudhuri S, Law S.

J Stem Cells. 2010;5(2):49-64.

PMID:
22049615
13.

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG.

Blood. 2009 Apr 30;113(18):4414-24. doi: 10.1182/blood-2008-10-182626. Epub 2009 Jan 29.

14.

Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis.

Shim GJ, Wang L, Andersson S, Nagy N, Kis LL, Zhang Q, Mäkelä S, Warner M, Gustafsson JA.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6694-9. Epub 2003 May 9. Erratum in: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8298.

15.

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling.

Vu T, Austin R, Kuhn CP, Bruedigam C, Song A, Guignes S, Jacquelin S, Ramshaw HS, Hill GR, Lopez AF, Lane SW.

Haematologica. 2016 Mar;101(3):e77-80. doi: 10.3324/haematol.2015.136705. Epub 2015 Nov 20. No abstract available.

16.

Lhx2 expression in hematopoietic progenitor/stem cells in vivo causes a chronic myeloproliferative disorder and altered globin expression.

Richter K, Pinto do O P, Hägglund AC, Wahlin A, Carlsson L.

Haematologica. 2003 Dec;88(12):1336-47.

17.

Transgenic mice expressing the p75 CCAAT-displacement protein/Cut homeobox isoform develop a myeloproliferative disease-like myeloid leukemia.

Cadieux C, Fournier S, Peterson AC, Bédard C, Bedell BJ, Nepveu A.

Cancer Res. 2006 Oct 1;66(19):9492-501.

18.

Immunohistochemical detection of p53, mdm2, waf1/p21, and Ki67 proteins in bone marrow biopsies in myelodysplastic syndroms, acute myelogenous leukaemias and chronic myeloproliferative disorders.

Kanavaros P, Stefanaki K, Rontogianni D, Darivianaki K, Vlychou M, Papadaki E, Eliopoulos G, Bakiri M, Matsouka C, Kakolyris S, Georgoulias V.

Clin Exp Pathol. 1999;47(5):231-8.

PMID:
10598372
19.

CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice.

Martelli MP, Pettirossi V, Thiede C, Bonifacio E, Mezzasoma F, Cecchini D, Pacini R, Tabarrini A, Ciurnelli R, Gionfriddo I, Manes N, Rossi R, Giunchi L, Oelschlägel U, Brunetti L, Gemei M, Delia M, Specchia G, Liso A, Di Ianni M, Di Raimondo F, Falzetti F, Del Vecchio L, Martelli MF, Falini B.

Blood. 2010 Nov 11;116(19):3907-22. doi: 10.1182/blood-2009-08-238899. Epub 2010 Jul 15.

PMID:
20634376
20.

Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.

Ramirez-Herrick AM, Mullican SE, Sheehan AM, Conneely OM.

Blood. 2011 Mar 3;117(9):2681-90. doi: 10.1182/blood-2010-02-267906. Epub 2011 Jan 4.

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