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Items: 1 to 20 of 93

1.

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).

Rowbottom MW, Bain G, Calderon I, Lasof T, Lonergan D, Lai A, Huang F, Darlington J, Prodanovich P, Santini AM, King CD, Goulet L, Shannon KE, Ma GL, Nguyen K, MacKenna DA, Evans JF, Hutchinson JH.

J Med Chem. 2017 May 25;60(10):4403-4423. doi: 10.1021/acs.jmedchem.7b00345. Epub 2017 May 15.

PMID:
28471663
2.

Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice.

Cosgrove D, Dufek B, Meehan DT, Delimont D, Hartnett M, Samuelson G, Gratton MA, Phillips G, MacKenna DA, Bain G.

Kidney Int. 2018 Aug;94(2):303-314. doi: 10.1016/j.kint.2018.02.024. Epub 2018 May 16.

PMID:
29759420
3.

Human lysyl oxidase-like 2.

Moon HJ, Finney J, Ronnebaum T, Mure M.

Bioorg Chem. 2014 Dec;57:231-241. doi: 10.1016/j.bioorg.2014.07.003. Epub 2014 Aug 1. Review.

4.

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.

Hutchinson JH, Rowbottom MW, Lonergan D, Darlington J, Prodanovich P, King CD, Evans JF, Bain G.

ACS Med Chem Lett. 2017 Mar 1;8(4):423-427. doi: 10.1021/acsmedchemlett.7b00014. eCollection 2017 Apr 13.

5.

Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.

Vadasz Z, Kessler O, Akiri G, Gengrinovitch S, Kagan HM, Baruch Y, Izhak OB, Neufeld G.

J Hepatol. 2005 Sep;43(3):499-507.

PMID:
16023247
6.

The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.

Kim YM, Kim EC, Kim Y.

Mol Biol Rep. 2011 Jan;38(1):145-9. doi: 10.1007/s11033-010-0088-0. Epub 2010 Mar 21.

PMID:
20306300
7.

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.

Chang J, Lucas MC, Leonte LE, Garcia-Montolio M, Singh LB, Findlay AD, Deodhar M, Foot JS, Jarolimek W, Timpson P, Erler JT, Cox TR.

Oncotarget. 2017 Apr 18;8(16):26066-26078. doi: 10.18632/oncotarget.15257.

8.

Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis.

Aumiller V, Strobel B, Romeike M, Schuler M, Stierstorfer BE, Kreuz S.

Sci Rep. 2017 Mar 10;7(1):149. doi: 10.1038/s41598-017-00270-0.

9.

Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation.

Iftikhar M, Hurtado P, Bais MV, Wigner N, Stephens DN, Gerstenfeld LC, Trackman PC.

J Biol Chem. 2011 Jan 14;286(2):909-18. doi: 10.1074/jbc.M110.155622. Epub 2010 Nov 11.

10.

Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.

Findlay AD, Foot JS, Buson A, Deodhar M, Jarnicki AG, Hansbro PM, Liu G, Schilter H, Turner CI, Zhou W, Jarolimek W.

J Med Chem. 2019 Nov 14;62(21):9874-9889. doi: 10.1021/acs.jmedchem.9b01283. Epub 2019 Oct 16.

PMID:
31580073
11.

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal.

Ikenaga N, Peng ZW, Vaid KA, Liu SB, Yoshida S, Sverdlov DY, Mikels-Vigdal A, Smith V, Schuppan D, Popov YV.

Gut. 2017 Sep;66(9):1697-1708. doi: 10.1136/gutjnl-2016-312473. Epub 2017 Jan 10.

12.

Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor.

Rodriguez HM, Vaysberg M, Mikels A, McCauley S, Velayo AC, Garcia C, Smith V.

J Biol Chem. 2010 Jul 2;285(27):20964-74. doi: 10.1074/jbc.M109.094136. Epub 2010 May 3.

13.

Lysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy.

Stangenberg S, Saad S, Schilter HC, Zaky A, Gill A, Pollock CA, Wong MG.

Sci Rep. 2018 Jun 21;8(1):9423. doi: 10.1038/s41598-018-27462-6.

14.

Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity.

Okada K, Moon HJ, Finney J, Meier A, Mure M.

Biochemistry. 2018 Dec 26;57(51):6973-6983. doi: 10.1021/acs.biochem.8b01008. Epub 2018 Dec 13.

15.

Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.

Mižíková I, Palumbo F, Tábi T, Herold S, Vadász I, Mayer K, Seeger W, Morty RE.

Physiol Genomics. 2017 Aug 1;49(8):416-429. doi: 10.1152/physiolgenomics.00026.2017. Epub 2017 Jul 10.

PMID:
28698228
16.

Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.

Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA.

J Clin Invest. 2017 Oct 2;127(10):3675-3688. doi: 10.1172/JCI94624. Epub 2017 Sep 5.

17.

Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity.

O'Rourke AM, Wang EY, Miller A, Podar EM, Scheyhing K, Huang L, Kessler C, Gao H, Ton-Nu HT, Macdonald MT, Jones DS, Linnik MD.

J Pharmacol Exp Ther. 2008 Feb;324(2):867-75. Epub 2007 Nov 9.

PMID:
17993604
18.

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.

Zhang X, Wang Q, Wu J, Wang J, Shi Y, Liu M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3828-3833. doi: 10.1073/pnas.1720859115. Epub 2018 Mar 26.

19.

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A, Martin A, Salvador F, Santos V, Boutros M, Rognoni E, Watt FM.

PLoS One. 2018 Jun 28;13(6):e0199679. doi: 10.1371/journal.pone.0199679. eCollection 2018.

20.

Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.

Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez HM, Oyasu M, Mikels A, Vaysberg M, Ghermazien H, Wai C, Garcia CA, Velayo AC, Jorgensen B, Biermann D, Tsai D, Green J, Zaffryar-Eilot S, Holzer A, Ogg S, Thai D, Neufeld G, Van Vlasselaer P, Smith V.

Nat Med. 2010 Sep;16(9):1009-17. doi: 10.1038/nm.2208. Epub 2010 Sep 5.

PMID:
20818376

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