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Items: 1 to 20 of 100

1.

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, Salatto CT, Coskran TM, Opsahl AC, Flynn D, Blatnik M, Li W, Kindt E, Foretz M, Viollet B, Ward J, Kurumbail RG, Kalgutkar AS, Wojtaszewski JFP, Cameron KO, Miller RA.

Cell Metab. 2017 May 2;25(5):1147-1159.e10. doi: 10.1016/j.cmet.2017.04.010.

2.

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.

Salatto CT, Miller RA, Cameron KO, Cokorinos E, Reyes A, Ward J, Calabrese MF, Kurumbail RG, Rajamohan F, Kalgutkar AS, Tess DA, Shavnya A, Genung NE, Edmonds DJ, Jatkar A, Maciejewski BS, Amaro M, Gandhok H, Monetti M, Cialdea K, Bollinger E, Kreeger JM, Coskran TM, Opsahl AC, Boucher GG, Birnbaum MJ, DaSilva-Jardine P, Rolph T.

J Pharmacol Exp Ther. 2017 May;361(2):303-311. doi: 10.1124/jpet.116.237925. Epub 2017 Mar 13.

PMID:
28289077
3.

Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells.

Lee WH, Lin RJ, Lin SY, Chen YC, Lin HM, Liang YC.

J Agric Food Chem. 2011 Dec 28;59(24):12874-81. doi: 10.1021/jf2036559. Epub 2011 Nov 28.

PMID:
22098542
4.

Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice.

Zhang LN, Xu L, Zhou HY, Wu LY, Li YY, Pang T, Xia CM, Qiu BY, Gu M, Dong TC, Li JY, Shen JK, Li J.

PLoS One. 2013 Aug 20;8(8):e72092. doi: 10.1371/journal.pone.0072092. eCollection 2013.

5.

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.

Esquejo RM, Salatto CT, Delmore J, Albuquerque B, Reyes A, Shi Y, Moccia R, Cokorinos E, Peloquin M, Monetti M, Barricklow J, Bollinger E, Smith BK, Day EA, Nguyen C, Geoghegan KF, Kreeger JM, Opsahl A, Ward J, Kalgutkar AS, Tess D, Butler L, Shirai N, Osborne TF, Steinberg GR, Birnbaum MJ, Cameron KO, Miller RA.

EBioMedicine. 2018 May;31:122-132. doi: 10.1016/j.ebiom.2018.04.009. Epub 2018 Apr 8.

6.

Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.

Musi N, Goodyear LJ.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):119-27. Review.

PMID:
12476786
7.

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Nimal S, Longnus SL, Van Obberghen E, Hainault I, Foufelle F, Kahn R, Braun U, Leitges M, Farese RV.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E179-92. doi: 10.1152/ajpendo.00392.2009. Epub 2009 Nov 3.

8.

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.

Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L.

J Biol Chem. 2010 Dec 24;285(52):40581-92. doi: 10.1074/jbc.M110.176545. Epub 2010 Oct 18.

9.

Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway.

Zheng T, Yang X, Wu D, Xing S, Bian F, Li W, Chi J, Bai X, Wu G, Chen X, Zhang Y, Jin S.

Br J Pharmacol. 2015 Jul;172(13):3284-301. doi: 10.1111/bph.13120. Epub 2015 Apr 24.

10.
11.

AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.

O'Neill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jørgensen SB, Schertzer JD, Shyroka O, Kiens B, van Denderen BJ, Tarnopolsky MA, Kemp BE, Richter EA, Steinberg GR.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16092-7. doi: 10.1073/pnas.1105062108. Epub 2011 Sep 6.

12.

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

Treebak JT, Birk JB, Hansen BF, Olsen GS, Wojtaszewski JF.

Am J Physiol Cell Physiol. 2009 Oct;297(4):C1041-52. doi: 10.1152/ajpcell.00051.2009. Epub 2009 Aug 5.

13.

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK).

Grempler R, Wolff M, Simon E, Schmid R, Eisele C, Rieber K, Fischer E, Mettel S, Gabrielyan O, Delic D, Luippold G, Redeman N.

PLoS One. 2018 May 25;13(5):e0197849. doi: 10.1371/journal.pone.0197849. eCollection 2018.

14.

Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation.

Li DJ, Huang F, Lu WJ, Jiang GJ, Deng YP, Shen FM.

Acta Physiol (Oxf). 2015 Mar;213(3):711-21. doi: 10.1111/apha.12421. Epub 2014 Nov 24.

PMID:
25382002
15.

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.

Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA.

Biochem J. 2015 May 1;467(3):461-72. doi: 10.1042/BJ20141142.

16.

Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase.

Jung DY, Kim JH, Lee H, Jung MH.

Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):587-593. doi: 10.1016/j.bbrc.2017.10.120. Epub 2017 Oct 25.

PMID:
29079190
17.

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.

Li YY, Yu LF, Zhang LN, Qiu BY, Su MB, Wu F, Chen DK, Pang T, Gu M, Zhang W, Ma WP, Jiang HW, Li JY, Nan FJ, Li J.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):325-34. doi: 10.1016/j.taap.2013.09.006. Epub 2013 Sep 18.

PMID:
24055643
18.

Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK.

Zou F, Mao XQ, Wang N, Liu J, Ou-Yang JP.

Acta Pharmacol Sin. 2009 Dec;30(12):1607-15. doi: 10.1038/aps.2009.168.

19.

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

Lai YC, Kviklyte S, Vertommen D, Lantier L, Foretz M, Viollet B, Hallén S, Rider MH.

Biochem J. 2014 Jun 15;460(3):363-75. doi: 10.1042/BJ20131673.

PMID:
24665903
20.

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.

Ducommun S, Ford RJ, Bultot L, Deak M, Bertrand L, Kemp BE, Steinberg GR, Sakamoto K.

Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E688-96. doi: 10.1152/ajpendo.00672.2013. Epub 2014 Jan 14.

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