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Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis.

Hsu YH, Yang YY, Huwang MH, Weng YH, Jou IM, Wu PT, Lin TY, Wu LW, Chang MS.

PLoS One. 2017 Apr 20;12(4):e0175802. doi: 10.1371/journal.pone.0175802. eCollection 2017.


The role of cytokines in osteoarthritis pathophysiology.

Fernandes JC, Martel-Pelletier J, Pelletier JP.

Biorheology. 2002;39(1-2):237-46. Review.


Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis.

Hu H, Yang B, Li Y, Zhang S, Li Z.

Int J Mol Med. 2016 Dec;38(6):1922-1932. doi: 10.3892/ijmm.2016.2770. Epub 2016 Oct 13.


Alpha-Mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model.

Pan T, Wu D, Cai N, Chen R, Shi X, Li B, Pan J.

Int Immunopharmacol. 2017 Nov;52:34-43. doi: 10.1016/j.intimp.2017.08.010. Epub 2017 Aug 31.


Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats.

Si HB, Zeng Y, Liu SY, Zhou ZK, Chen YN, Cheng JQ, Lu YR, Shen B.

Osteoarthritis Cartilage. 2017 Oct;25(10):1698-1707. doi: 10.1016/j.joca.2017.06.002. Epub 2017 Jun 21.


Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.

Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB.

Arthritis Res Ther. 2014 Dec 17;16(6):508. doi: 10.1186/s13075-014-0508-y. Erratum in: Arthritis Res Ther. 2019 Jan 3;21(1):1.


Interleukin-20 antibody is a potential therapeutic agent for experimental arthritis.

Hsu YH, Chang MS.

Arthritis Rheum. 2010 Nov;62(11):3311-21. doi: 10.1002/art.27689.


Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway.

Wang Z, Huang J, Zhou S, Luo F, Xu W, Wang Q, Tan Q, Chen L, Wang J, Chen H, Chen L, Xie Y, Du X.

J Cell Mol Med. 2017 Dec;21(12):3231-3243. doi: 10.1111/jcmm.13227. Epub 2017 Jun 23.


IL-6 in Osteoarthritis: Effects of Pine Stilbenoids.

Laavola M, Leppänen T, Hämäläinen M, Vuolteenaho K, Moilanen T, Nieminen R, Moilanen E.

Molecules. 2018 Dec 29;24(1). pii: E109. doi: 10.3390/molecules24010109.


Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis.

Joosten LA, Lubberts E, Helsen MM, Saxne T, Coenen-de Roo CJ, Heinegård D, van den Berg WB.

Arthritis Res. 1999;1(1):81-91. Epub 1999 Oct 26.


Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response.

Furuzawa-Carballeda J, Macip-Rodríguez PM, Cabral AR.

Clin Exp Rheumatol. 2008 Jul-Aug;26(4):554-60.


Chondroprotective effects of aqueous extract of Anthriscus sylvestris leaves on osteoarthritis in vitro and in vivo through MAPKs and NF-κB signaling inhibition.

Lee SA, Moon SM, Han SH, Hwang EJ, Park BR, Kim JS, Kim DK, Kim CS.

Biomed Pharmacother. 2018 Jul;103:1202-1211. doi: 10.1016/j.biopha.2018.04.183. Epub 2018 May 7.


Effect of Ermiao Recipe with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats.

Xu Y, Dai GJ, Liu Q, Ma XP, Li L, Chen WH, Lin N.

Chin J Integr Med. 2014 Aug;20(8):600-9. doi: 10.1007/s11655-014-1761-2. Epub 2014 Aug 5.


Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.

Feng Z, Zheng W, Li X, Lin J, Xie C, Li H, Cheng L, Wu A, Ni W.

Int Immunopharmacol. 2017 Sep;50:161-167. doi: 10.1016/j.intimp.2017.06.017. Epub 2017 Jun 27.


Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor.

Attur M, Al-Mussawir HE, Patel J, Kitay A, Dave M, Palmer G, Pillinger MH, Abramson SB.

J Immunol. 2008 Oct 1;181(7):5082-8. Erratum in: J Immunol. 2009 Jul 15;183(2):1496.


Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.

Ding QH, Ye CY, Chen EM, Zhang W, Wang XH.

Int Immunopharmacol. 2018 Aug;61:222-230. doi: 10.1016/j.intimp.2018.05.026. Epub 2018 Jun 8.


Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling.

Jiang Y, Hu C, Yu S, Yan J, Peng H, Ouyang HW, Tuan RS.

Arthritis Res Ther. 2015 Nov 17;17:327. doi: 10.1186/s13075-015-0840-x.


Lithium protects against cartilage degradation in osteoarthritis.

Minashima T, Zhang Y, Lee Y, Kirsch T.

Arthritis Rheumatol. 2014 May;66(5):1228-36. doi: 10.1002/art.38373.

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