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Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer.

Wang L, Yang D, Tian J, Gao A, Shen Y, Ren X, Li X, Jiang G, Dong T.

Oncotarget. 2017 Apr 18;8(16):26323-26333. doi: 10.18632/oncotarget.15461.


Fibroblast activation protein-α in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways.

Cao F, Wang S, Wang H, Tang W.

Mol Med Rep. 2018 Feb;17(2):2593-2599. doi: 10.3892/mmr.2017.8155. Epub 2017 Nov 27.


Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2.

Li M, Liu Y, Xia F, Wu Z, Deng L, Jiang R, Guo FJ.

Cell Signal. 2014 Jul;26(7):1539-48. doi: 10.1016/j.cellsig.2014.03.026. Epub 2014 Apr 1.


Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways.

Yang D, Wang LL, Dong TT, Shen YH, Guo XS, Liu CY, Liu J, Zhang P, Li J, Sun YP.

Am J Cancer Res. 2015 Sep 15;5(10):3085-97. eCollection 2015.


Clinical implications of progranulin in gastric cancer and its regulation via a positive feedback loop involving AKT and ERK signaling pathways.

Yang D, Li R, Wang H, Wang J, Han L, Pan L, Li X, Kong Q, Wang G, Su X.

Mol Med Rep. 2017 Dec;16(6):9685-9691. doi: 10.3892/mmr.2017.7796. Epub 2017 Oct 17.


Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway.

Dai G, Yao X, Zhang Y, Gu J, Geng Y, Xue F, Zhang J.

Bull Cancer. 2018 Apr;105(4):336-349. doi: 10.1016/j.bulcan.2017.12.009. Epub 2018 Feb 26.


PGRN promotes migration and invasion of epithelial ovarian cancer cells through an epithelial mesenchymal transition program and the activation of cancer associated fibroblasts.

Dong T, Yang D, Li R, Zhang L, Zhao H, Shen Y, Zhang X, Kong B, Wang L.

Exp Mol Pathol. 2016 Feb;100(1):17-25. doi: 10.1016/j.yexmp.2015.11.021. Epub 2015 Dec 1.


Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma.

Tian B, Chen X, Zhang H, Li X, Wang J, Han W, Zhang LY, Fu L, Li Y, Nie C, Zhao Y, Tan X, Wang H, Guan XY, Hong A.

Oncotarget. 2017 Jun 27;8(26):42300-42313. doi: 10.18632/oncotarget.15857.


Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling.

Liu F, Zhang W, Yang F, Feng T, Zhou M, Yu Y, Yu X, Zhao W, Yi F, Tang W, Lu Y.

Sci Rep. 2016 Feb 16;6:21260. doi: 10.1038/srep21260.


STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways.

Chen B, Zeng X, He Y, Wang X, Liang Z, Liu J, Zhang P, Zhu H, Xu N, Liang S.

Oncotarget. 2016 Nov 1;7(44):71400-71416. doi: 10.18632/oncotarget.12147.


GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.

Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C, Wei Y.

Carcinogenesis. 2013 Dec;34(12):2861-9. doi: 10.1093/carcin/bgt229. Epub 2013 Jun 26.


ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.

Ye Q, Cai W, Zheng Y, Evers BM, She QB.

Oncogene. 2014 Apr 3;33(14):1828-39. doi: 10.1038/onc.2013.122. Epub 2013 Apr 29.


Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway.

Feng T, Zheng L, Liu F, Xu X, Mao S, Wang X, Liu J, Lu Y, Zhao W, Yu X, Tang W.

Oncotarget. 2016 Sep 6;7(36):58381-58395. doi: 10.18632/oncotarget.11126.


Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways.

Zhao J, Ou B, Han D, Wang P, Zong Y, Zhu C, Liu D, Zheng M, Sun J, Feng H, Lu A.

Mol Cancer. 2017 Mar 29;16(1):70. doi: 10.1186/s12943-017-0629-4.


Cancer-associated fibroblasts promote proliferation of endometrial cancer cells.

Subramaniam KS, Tham ST, Mohamed Z, Woo YL, Mat Adenan NA, Chung I.

PLoS One. 2013 Jul 26;8(7):e68923. doi: 10.1371/journal.pone.0068923. Print 2013.


Integrin αvβ6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts.

Peng C, Zou X, Xia W, Gao H, Li Z, Liu N, Xu Z, Gao C, He Z, Niu W, Fang R, Biswas S, Agrez M, Zhi X, Niu J.

Biosci Rep. 2018 Dec 7;38(6). pii: BSR20180243. doi: 10.1042/BSR20180243. Print 2018 Dec 21.


Podoplanin, α-smooth muscle actin or S100A4 expressing cancer-associated fibroblasts are associated with different prognosis in colorectal cancers.

Choi SY, Sung R, Lee SJ, Lee TG, Kim N, Yoon SM, Lee EJ, Chae HB, Youn SJ, Park SM.

J Korean Med Sci. 2013 Sep;28(9):1293-301. doi: 10.3346/jkms.2013.28.9.1293. Epub 2013 Aug 28.


Oxidized ATM promotes abnormal proliferation of breast CAFs through maintaining intracellular redox homeostasis and activating the PI3K-AKT, MEK-ERK, and Wnt-β-catenin signaling pathways.

Tang S, Hou Y, Zhang H, Tu G, Yang L, Sun Y, Lang L, Tang X, Du YE, Zhou M, Yu T, Xu L, Wen S, Liu C, Liu M.

Cell Cycle. 2015;14(12):1908-24. doi: 10.1080/15384101.2015.1041685.


Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.

Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Lin SJ, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P.

Gastroenterology. 2017 Jul;153(1):191-204.e16. doi: 10.1053/j.gastro.2017.03.046. Epub 2017 Apr 5.


IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment.

Zheng X, Xu M, Yao B, Wang C, Jia Y, Liu Q.

Cell Signal. 2016 Sep;28(9):1314-24. doi: 10.1016/j.cellsig.2016.06.009. Epub 2016 Jun 11.


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