Similar articles for PMID: 28351607

Year	Number of Results
2005	2
2007	1
2008	2
2009	1
2011	3
2012	5
2013	7
2014	16
2015	11
2016	19
2017	21
2018	13
2019	8
2020	11
2021	6
2022	6
2023	2
2024	0

1

Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth.

Edupuganti R, Taliaferro JM, Wang Q, Xie X, Cho EJ, Vidhu F, Ren P, Anslyn EV, Bartholomeusz C, Dalby KN. Edupuganti R, et al. Bioorg Med Chem. 2017 May 1;25(9):2609-2616. doi: 10.1016/j.bmc.2017.03.018. Epub 2017 Mar 10. Bioorg Med Chem. 2017. PMID: 28351607

2

MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.

Pitner MK, Taliaferro JM, Dalby KN, Bartholomeusz C. Pitner MK, et al. Expert Opin Ther Targets. 2017 Sep;21(9):849-859. doi: 10.1080/14728222.2017.1363183. Epub 2017 Aug 16. Expert Opin Ther Targets. 2017. PMID: 28764577 Review.

3

Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.

Simon M, Mesmar F, Helguero L, Williams C. Simon M, et al. PLoS One. 2017 Feb 24;12(2):e0172832. doi: 10.1371/journal.pone.0172832. eCollection 2017. PLoS One. 2017. PMID: 28235006 Free PMC article.

4

A novel carbon-11 radiolabeled maternal embryonic leucine zipper kinase inhibitor for PET imaging of triple-negative breast cancer.

Tang R, Gai Y, Li K, Hu F, Gong C, Wang S, Feng F, Altine B, Hu J, Lan X. Tang R, et al. Bioorg Chem. 2021 Feb;107:104609. doi: 10.1016/j.bioorg.2020.104609. Epub 2021 Jan 5. Bioorg Chem. 2021. PMID: 33454507

5

Structure-based discovery of new maternal embryonic leucine zipper kinase inhibitors.

Zhou S, Li GB, Luo L, Zhong L, Chen K, Li H, Jiang XJ, Fu Q, Long X, Bao JK. Zhou S, et al. Org Biomol Chem. 2018 Feb 28;16(9):1489-1495. doi: 10.1039/c7ob02344h. Org Biomol Chem. 2018. PMID: 29411820

6

Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia.

Zhang Y, Zhou X, Li Y, Xu Y, Lu K, Li P, Wang X. Zhang Y, et al. Oncogene. 2018 Oct;37(41):5520-5533. doi: 10.1038/s41388-018-0333-x. Epub 2018 Jun 12. Oncogene. 2018. PMID: 29895969

7

Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example.

Mahasenan KV, Li C. Mahasenan KV, et al. J Chem Inf Model. 2012 May 25;52(5):1345-55. doi: 10.1021/ci300040c. Epub 2012 May 8. J Chem Inf Model. 2012. PMID: 22540736

8

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.

Touré BB, Giraldes J, Smith T, Sprague ER, Wang Y, Mathieu S, Chen Z, Mishina Y, Feng Y, Yan-Neale Y, Shakya S, Chen D, Meyer M, Puleo D, Brazell JT, Straub C, Sage D, Wright K, Yuan Y, Chen X, Duca J, Kim S, Tian L, Martin E, Hurov K, Shao W. Touré BB, et al. J Med Chem. 2016 May 26;59(10):4711-23. doi: 10.1021/acs.jmedchem.6b00052. Epub 2016 May 17. J Med Chem. 2016. PMID: 27187609

9

Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.

McDonald IM, Grant GD, East MP, Gilbert TSK, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM. McDonald IM, et al. J Biol Chem. 2020 Feb 21;295(8):2359-2374. doi: 10.1074/jbc.RA119.011083. Epub 2020 Jan 2. J Biol Chem. 2020. PMID: 31896573 Free PMC article.

10

Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.

Inoue H, Kato T, Olugbile S, Tamura K, Chung S, Miyamoto T, Matsuo Y, Salgia R, Nakamura Y, Park JH. Inoue H, et al. Oncotarget. 2016 Mar 22;7(12):13621-33. doi: 10.18632/oncotarget.7297. Oncotarget. 2016. PMID: 26871945 Free PMC article.

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