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The signaling signature of the neurotensin type 1 receptor with endogenous ligands.

Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R.

Eur J Pharmacol. 2017 Jun 15;805:1-13. doi: 10.1016/j.ejphar.2017.03.046. Epub 2017 Mar 22.


Biased signaling at chemokine receptors.

Corbisier J, Galès C, Huszagh A, Parmentier M, Springael JY.

J Biol Chem. 2015 Apr 10;290(15):9542-54. doi: 10.1074/jbc.M114.596098. Epub 2015 Jan 22.


Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways.

Zhou Q, Li G, Deng XY, He XB, Chen LJ, Wu C, Shi Y, Wu KP, Mei LJ, Lu JX, Zhou NM.

Br J Pharmacol. 2012 Jul;166(6):1756-73. doi: 10.1111/j.1476-5381.2012.01875.x.


Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2006 Apr 21;281(16):10856-64. Epub 2006 Feb 21.


Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1.

Law IK, Murphy JE, Bakirtzi K, Bunnett NW, Pothoulakis C.

J Biol Chem. 2012 Apr 27;287(18):15066-75. doi: 10.1074/jbc.M111.327262. Epub 2012 Mar 13.


beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ.

J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9.


Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system.

Perron A, Sarret P, Gendron L, Stroh T, Beaudet A.

J Biol Chem. 2005 Mar 18;280(11):10219-27. Epub 2005 Jan 6.


Formyl peptide receptor-mediated ERK1/2 activation occurs through G(i) and is not dependent on beta-arrestin1/2.

Gripentrog JM, Miettinen HM.

Cell Signal. 2008 Feb;20(2):424-31. Epub 2007 Nov 9.


Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5160-8. doi: 10.1073/pnas.1508836112. Epub 2015 Aug 31.


Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel β-arrestin-2-biased pathway.

Liu H, Tian Y, Ji B, Lu H, Xin Q, Jiang Y, Ding L, Zhang J, Chen J, Bai B.

Biochim Biophys Acta. 2016 Nov;1863(11):2719-2738. doi: 10.1016/j.bbamcr.2016.07.009. Epub 2016 Aug 12.


Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.

Gendron L, Perron A, Payet MD, Gallo-Payet N, Sarret P, Beaudet A.

Mol Pharmacol. 2004 Dec;66(6):1421-30. Epub 2004 Sep 10.


Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24.

Poinot-Chazel C, Portier M, Bouaboula M, Vita N, Pecceu F, Gully D, Monroe JG, Maffrand JP, Le Fur G, Casellas P.

Biochem J. 1996 Nov 15;320 ( Pt 1):145-51.


Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.

Stroth N, Niso M, Colabufo NA, Perrone R, Svenningsson P, Lacivita E, Leopoldo M.

Bioorg Med Chem. 2015 Aug 1;23(15):4824-30. doi: 10.1016/j.bmc.2015.05.042. Epub 2015 Jun 1.


The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism.

van der Westhuizen ET, Werry TD, Sexton PM, Summers RJ.

Mol Pharmacol. 2007 Jun;71(6):1618-29. Epub 2007 Mar 9.


Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.

Kumar P, Lau CS, Mathur M, Wang P, DeFea KA.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C346-57. Epub 2007 Apr 18.


The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network.

Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM.

J Biol Chem. 2011 Jun 3;286(22):19880-91. doi: 10.1074/jbc.M111.233080. Epub 2011 Apr 18.

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