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Items: 1 to 20 of 102

1.

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.

2.

Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling.

Baran P, Nitz R, Grötzinger J, Scheller J, Garbers C.

J Biol Chem. 2013 May 24;288(21):14756-68. doi: 10.1074/jbc.M113.466169. Epub 2013 Apr 5.

3.

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J.

Biochim Biophys Acta. 2014 Sep;1842(9):1485-94. doi: 10.1016/j.bbadis.2014.05.018. Epub 2014 May 27.

4.

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.

Sci Rep. 2016 May 6;6:25550. doi: 10.1038/srep25550.

5.

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.

Schumacher N, Meyer D, Mauermann A, von der Heyde J, Wolf J, Schwarz J, Knittler K, Murphy G, Michalek M, Garbers C, Bartsch JW, Guo S, Schacher B, Eickholz P, Chalaris A, Rose-John S, Rabe B.

J Biol Chem. 2015 Oct 23;290(43):26059-71. doi: 10.1074/jbc.M115.649509. Epub 2015 Sep 10.

6.

Enhancing Interleukin-6 and Interleukin-11 receptor cleavage.

Lokau J, Wandel M, Garbers C.

Int J Biochem Cell Biol. 2017 Apr;85:6-14. doi: 10.1016/j.biocel.2017.01.014. Epub 2017 Jan 29.

PMID:
28143719
7.

Regulation of soluble interleukin-6 (IL-6) receptor release from corneal epithelial cells and its role in the ocular surface.

Sugaya S, Sakimoto T, Shoji J, Sawa M.

Jpn J Ophthalmol. 2011 May;55(3):277-282. doi: 10.1007/s10384-011-0002-x. Epub 2011 Apr 27.

PMID:
21523377
8.

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).

Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J.

Cell Cycle. 2013 Nov 1;12(21):3421-32. doi: 10.4161/cc.26431. Epub 2013 Sep 18.

9.

Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.

Wolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, Garbers C.

J Biol Chem. 2016 Jul 29;291(31):16186-96. doi: 10.1074/jbc.M116.718551. Epub 2016 May 23.

10.

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.

Franke M, Schröder J, Monhasery N, Ackfeld T, Hummel TM, Rabe B, Garbers C, Becker-Pauly C, Floss DM, Scheller J.

J Biol Chem. 2016 May 13;291(20):10551-61. doi: 10.1074/jbc.M115.710541. Epub 2016 Mar 9.

11.

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.

12.

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.

Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J.

J Biol Chem. 2011 Apr 29;286(17):14804-11. doi: 10.1074/jbc.M111.229393. Epub 2011 Mar 15.

13.

ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.

Herzog C, Haun RS, Ludwig A, Shah SV, Kaushal GP.

J Biol Chem. 2014 May 9;289(19):13308-22. doi: 10.1074/jbc.M114.559088. Epub 2014 Mar 24.

14.

The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.

Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR, Moll JM, Scheller J.

J Biol Chem. 2018 May 4;293(18):6762-6775. doi: 10.1074/jbc.RA117.001163. Epub 2018 Mar 20.

PMID:
29559558
15.

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.

PLoS Biol. 2017 Jan 6;15(1):e2000080. doi: 10.1371/journal.pbio.2000080. eCollection 2017 Jan.

16.

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.

Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker HW, Chalaris A.

J Leukoc Biol. 2016 May;99(5):749-60. doi: 10.1189/jlb.3A0515-207R. Epub 2015 Nov 11.

PMID:
26561568
17.
18.

Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts.

Vermes C, Jacobs JJ, Zhang J, Firneisz G, Roebuck KA, Glant TT.

J Biol Chem. 2002 May 10;277(19):16879-87. Epub 2002 Mar 7.

19.
20.

The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.

Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J.

Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. doi: 10.1016/j.ejcb.2010.10.007. Epub 2010 Dec 8. Review.

PMID:
21145125

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