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28228218,28202415,21903093,21660448,26983803,22982206,28624529,26661339,29964331,27484784,27512955,26212606,24612139,20686688,19074830,21292685,31281953,25531448,29070784,22848091,24939851,30061204,22354145,26203587,30132536,27731378,20669244,27603596,24530917,26900933,17143496,30160785,23615398,28467689,31102888,23536831,23335397,23986445,25646742,18172319,30463333,22447040,26706948,16024639,28471808,21348302,23982257,17510429,29535810,23644112,27039295,26111475,17684158,18164688,17575157,31019655,24078627,18424742,16613838,21697087,21854768,25321472,21726997,23224239,30817944,21801359,24188478,23064375,29131242,23261452,32506763,34681736,20837473,20113484,27260301,18593935,18793956,25596735,29970185,22200406,18341587,22472572,21167276,22400995,22072062,31083595,21801305,30061216,29533936,11156424,20515942,27780136,19939880,18974136,20159939,21817114,17431117,17493934,30689998,28242652,20360945,27629794,30742128,24866585,30257253,25015549,30589515,18794136,28966297,33586156,26331107,31126284,30221676,28270124,30862357,30167846,17172826,26054751,18852146,21538027,24213373,26169264,34080659,32124960,21941003,33050112,30870485,23053497,30317758,30737960,32705218,31638255,29929000,27612013,31810927,28936683,28209994,32722598,22020938,30297634,26837170,24289635,24387758,30692634,30556589,31904339,32777260,20978316,23580227,30423122,32626921,33632873,23348585,20037825,28476883,23431365,30138935,22622069,20714870,20096292,18187663,35948134,35008442,19737941,33984327,30359578,29671785,22004570,30199885,33007289,31731196,37116152,22179661,29694835,26843620,20515924,34475055,20623264,29615720,28972304,31561852,26170696,30332761,30132512,32106370,21965726,27406983,31306050,29717117,34582654,31336136,24136147,19426686,27453209,29196971,29661248,28409774,33000263,19540014,24971463,21081474,21133714,19674787,36012252,25023940,26081590,36076591,30718520,25173558,24142645,31864387,30708101,17895594,23628031,19738990,26163602,21206980,23027370,30674532,28108622,29973205,23347256,29442009,25102912,30642878,25666501,33108704,15322075,26882807,31546731,30359552,29016934,22936321,30448845,32543134,29802332,31418364,19604313,20154087,24551275,18375389,29374147,30130653,25293521,34599545,32441887,25033286,29638207,18284607,29663486,19643115,29268854,21044953,28662515,30730256,18980980,27428937,36853289,23203129,25233628,25887496,29383484,31075907,28981087,29901077,27602754,26512246,20878528,35568793,30017320,32109381,23833311,29860757,28718726,22320973,29991746,28560396,29063676,25031778,32200503,18998361,30864676,35902739,29483839,35900550,24466325,29272788,30647121,21297379,20371719,29764928,36675245,31707450,33122623,31847860,18978361,35985770,33841136,29543750,34926196,31889078,26137077,30111400,36271571,20003459,22185222,30131570,22643355,23015779,26081757,24789911,21146890,23071253,26581488,25343626,32982432,31704813,31516571,26942880,35011619,36344842,24490570,34999051,32239867,32433558,34004082,27293989,28994313,30626136,22419388,30614530,35744931,30621488,30717537,22942757,29576846,22562097,28345958,29551769,20224297,25127663,25580686,30848542,31850162,35994698,32734538,32878791,27703527,26710957,23821365,32247582,34848451,33450317,25907934,36775838,30575033,35077998,31618900,24453000,33812409,22949836,23192275,35616096,30662337,24795528,33465424,25917567,26234135,28423492,27165241,33050333,20953314,33909909,34932899,26898246,31704709,29747368,27626799,26111690,30553142,20663526,26798390,31295479,25770212,31966615,32283836,25052611,31180536,16196298,18227621,30258037,17849272,33731677,28706453,24740347,35682540,35115486,29556305,24137422,23887632,34696710,23908588,34813867,31916474,19230044,32825566,31032087,25124560,18667695,30613368,34272796,32116190,18313665,25349561,20924496,32941010,26121872,24989930,30792889,31433987,19568915,19823030,29600563,20839416,35428370,28984868,34573124,31623058,25027654,31257814,33240775,26491348,35149588,29354301,33966046,27149887,23097656,28990932,29798416,24510348,26698404,34187946,30181698,28986701,27175086,32208160,25323748,27698877,35049031,29218092,32624694,36622548,28529596,25337580,31839995,21811429,34986539,36460128,23805861,35809792,24589588,32604833,33963815,31090971,35804815,30651925,29805529,32370057,34607978,31906414,32899699,37076638,32321866,29719463,24222778,36524823,30131338,36983900,32766144,27190933,35882449,33868476,32514253,24324518,36755015,24980813,30344724,28650792,23861942,22111039,25110459,34307504,34589486,34549714,33557839,29018571,31281836,34053426,36768961,34170142,36675536,33505114,27822364,26178512,31822725,30344674,29136758,25960850,34527710,29545899,28521465,28032027,22363901,30713790,33937072,35075141,28696570,30209930,19081762,29768226,31807365,34405011,34567145,27628049,29344260,30709582,37060507,35745636,32591457,29085455,34451917,25337465,34237907,35731146,26759824,24578267,26331219,23455019[uid]

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[Thioridazine Sensitizes Apoptotic Effect of TRAIL in Human Lung Cancer PC9 Cells Through ER Stress Mediated Up-regulation of DR5].

Li J, Wang Y, Liu L, Yuan Y, Bao Y. Li J, et al. Zhongguo Fei Ai Za Zhi. 2017 Feb 20;20(2):80-87. doi: 10.3779/j.issn.1009-3419.2017.02.02. Zhongguo Fei Ai Za Zhi. 2017. PMID: 28228218 Free PMC article. Chinese.

Glutamine deprivation sensitizes human breast cancer MDA-MB-231 cells to TRIAL-mediated apoptosis.

Dilshara MG, Jeong JW, Prasad Tharanga Jayasooriya RG, Neelaka Molagoda IM, Lee S, Park SR, Choi YH, Kim GY. Dilshara MG, et al. Biochem Biophys Res Commun. 2017 Apr 1;485(2):440-445. doi: 10.1016/j.bbrc.2017.02.059. Epub 2017 Feb 13. Biochem Biophys Res Commun. 2017. PMID: 28202415

Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress.

Moon DO, Park SY, Choi YH, Ahn JS, Kim GY. Moon DO, et al. Biochem Pharmacol. 2011 Dec 1;82(11):1641-50. doi: 10.1016/j.bcp.2011.08.019. Epub 2011 Aug 31. Biochem Pharmacol. 2011. PMID: 21903093

5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells.

Yang JF, Cao JG, Tian L, Liu F. Yang JF, et al. Cancer Chemother Pharmacol. 2012 Jan;69(1):195-206. doi: 10.1007/s00280-011-1686-9. Epub 2011 Jun 10. Cancer Chemother Pharmacol. 2012. PMID: 21660448

Tanshinone IIA induces TRAIL sensitization of human lung cancer cells through selective ER stress induction.

Kim EO, Kang SE, Im CR, Lee JH, Ahn KS, Yang WM, Um JY, Lee SG, Yun M. Kim EO, et al. Int J Oncol. 2016 May;48(5):2205-12. doi: 10.3892/ijo.2016.3441. Epub 2016 Mar 15. Int J Oncol. 2016. PMID: 26983803

Verrucarin A sensitizes TRAIL-induced apoptosis via the upregulation of DR5 in an eIF2α/CHOP-dependent manner.

Moon DO, Asami Y, Long H, Jang JH, Bae EY, Kim BY, Choi YH, Kang CH, Ahn JS, Kim GY. Moon DO, et al. Toxicol In Vitro. 2013 Feb;27(1):257-63. doi: 10.1016/j.tiv.2012.09.001. Epub 2012 Sep 12. Toxicol In Vitro. 2013. PMID: 22982206

Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL-induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation.

Na YJ, Lee DH, Kim JL, Kim BR, Park SH, Jo MJ, Jeong S, Kim HJ, Lee SY, Jeong YA, Oh SC. Na YJ, et al. Int J Biochem Cell Biol. 2017 Aug;89:147-156. doi: 10.1016/j.biocel.2017.06.010. Epub 2017 Jun 15. Int J Biochem Cell Biol. 2017. PMID: 28624529

Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers.

Kim J, Yun M, Kim EO, Jung DB, Won G, Kim B, Jung JH, Kim SH. Kim J, et al. Br J Pharmacol. 2016 Mar;173(6):1033-44. doi: 10.1111/bph.13408. Epub 2016 Feb 22. Br J Pharmacol. 2016. PMID: 26661339 Free PMC article.

Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.

Kim SY, Hong M, Heo SH, Park S, Kwon TK, Sung YH, Oh Y, Lee S, Yi GS, Kim I. Kim SY, et al. Mol Carcinog. 2018 Nov;57(11):1492-1506. doi: 10.1002/mc.22872. Epub 2018 Jul 19. Mol Carcinog. 2018. PMID: 29964331

Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.

Liu Z, Shi Q, Song X, Wang Y, Wang Y, Song E, Song Y. Liu Z, et al. Chem Res Toxicol. 2016 Sep 19;29(9):1510-8. doi: 10.1021/acs.chemrestox.6b00181. Epub 2016 Aug 16. Chem Res Toxicol. 2016. PMID: 27484784

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