Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 102

1.

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.

Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):157-170.e14. doi: 10.1016/j.cels.2016.12.011. Epub 2017 Jan 25.

2.

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.

Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet JC, Lindquist S.

Nat Genet. 2009 Mar;41(3):308-15. doi: 10.1038/ng.300. Epub 2009 Feb 1.

3.

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S.

Science. 2013 Nov 22;342(6161):979-83. doi: 10.1126/science.1245321. Epub 2013 Oct 24.

4.

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.

Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818. doi: 10.1073/pnas.1713129115. Epub 2018 Jul 10.

5.

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production.

Paillusson S, Gomez-Suaga P, Stoica R, Little D, Gissen P, Devine MJ, Noble W, Hanger DP, Miller CCJ.

Acta Neuropathol. 2017 Jul;134(1):129-149. doi: 10.1007/s00401-017-1704-z. Epub 2017 Mar 23.

6.

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.

Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S.

Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208. doi: 10.1242/dmm.004267. Epub 2009 Dec 28.

7.

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.

Usenovic M, Knight AL, Ray A, Wong V, Brown KR, Caldwell GA, Caldwell KA, Stagljar I, Krainc D.

Hum Mol Genet. 2012 Sep 1;21(17):3785-94. doi: 10.1093/hmg/dds206. Epub 2012 May 29.

8.

Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.

Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D.

J Neurosci. 2016 Jul 20;36(29):7693-706. doi: 10.1523/JNEUROSCI.0628-16.2016.

9.

Parkinson's disease in a dish - Using stem cells as a molecular tool.

Badger JL, Cordero-Llana O, Hartfield EM, Wade-Martins R.

Neuropharmacology. 2014 Jan;76 Pt A:88-96. doi: 10.1016/j.neuropharm.2013.08.035. Epub 2013 Sep 10. Review.

PMID:
24035919
10.

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.

Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD.

Neuron. 2015 Jan 7;85(1):76-87. doi: 10.1016/j.neuron.2014.11.027. Epub 2014 Dec 18. Erratum in: Neuron. 2015 Feb 4;85(3):657.

11.

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.

Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):145-50. Epub 2007 Dec 27.

12.

Linking the VPS35 and EIF4G1 pathways in Parkinson's disease.

Ross OA, Cook C, Petrucelli L.

Neuron. 2015 Jan 7;85(1):1-3. doi: 10.1016/j.neuron.2014.12.045.

13.

Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.

Briffa M, Ghio S, Neuner J, Gauci AJ, Cacciottolo R, Marchal C, Caruana M, Cullin C, Vassallo N, Cauchi RJ.

Neurosci Lett. 2017 Jan 18;638:12-20. doi: 10.1016/j.neulet.2016.11.058. Epub 2016 Dec 2.

PMID:
27919712
14.

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.

López de Maturana R, Lang V, Zubiarrain A, Sousa A, Vázquez N, Gorostidi A, Águila J, López de Munain A, Rodríguez M, Sánchez-Pernaute R.

J Neuroinflammation. 2016 Nov 18;13(1):295.

15.

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S.

Science. 2013 Nov 22;342(6161):983-7. doi: 10.1126/science.1245296. Epub 2013 Oct 24.

16.

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.

Devine MJ, Ryten M, Vodicka P, Thomson AJ, Burdon T, Houlden H, Cavaleri F, Nagano M, Drummond NJ, Taanman JW, Schapira AH, Gwinn K, Hardy J, Lewis PA, Kunath T.

Nat Commun. 2011 Aug 23;2:440. doi: 10.1038/ncomms1453.

17.

In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.

Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):242-250.e4. doi: 10.1016/j.cels.2017.01.002. Epub 2017 Jan 25.

18.

Novel suppressors of alpha-synuclein toxicity identified using yeast.

Liang J, Clark-Dixon C, Wang S, Flower TR, Williams-Hart T, Zweig R, Robinson LC, Tatchell K, Witt SN.

Hum Mol Genet. 2008 Dec 1;17(23):3784-95. doi: 10.1093/hmg/ddn276. Epub 2008 Sep 4.

19.

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ.

Hum Mol Genet. 2012 Jun 1;21(11):2420-31. doi: 10.1093/hmg/dds057. Epub 2012 Feb 21.

20.

Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae.

Soper JH, Roy S, Stieber A, Lee E, Wilson RB, Trojanowski JQ, Burd CG, Lee VM.

Mol Biol Cell. 2008 Mar;19(3):1093-103. doi: 10.1091/mbc.E07-08-0827. Epub 2008 Jan 2. Erratum in: Mol Biol Cell. 2008 May;19(5):2348.

Supplemental Content

Support Center