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Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism.

Philbrick KA, Wong CP, Branscum AJ, Turner RT, Iwaniec UT.

J Endocrinol. 2017 Mar;232(3):461-474. doi: 10.1530/JOE-16-0484. Epub 2017 Jan 5.


Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice.

Bartell SM, Rayalam S, Ambati S, Gaddam DR, Hartzell DL, Hamrick M, She JX, Della-Fera MA, Baile CA.

J Bone Miner Res. 2011 Aug;26(8):1710-20. doi: 10.1002/jbmr.406.


Peripheral leptin regulates bone formation.

Turner RT, Kalra SP, Wong CP, Philbrick KA, Lindenmaier LB, Boghossian S, Iwaniec UT.

J Bone Miner Res. 2013 Jan;28(1):22-34. doi: 10.1002/jbmr.1734.


Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice.

Hamrick MW, Della-Fera MA, Choi YH, Pennington C, Hartzell D, Baile CA.

J Bone Miner Res. 2005 Jun;20(6):994-1001. Epub 2005 Jan 18.


Hypothalamic control of bone formation: distinct actions of leptin and y2 receptor pathways.

Baldock PA, Sainsbury A, Allison S, Lin EJ, Couzens M, Boey D, Enriquez R, During M, Herzog H, Gardiner EM.

J Bone Miner Res. 2005 Oct;20(10):1851-7. Epub 2005 May 31.


Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice.

Turner RT, Philbrick KA, Wong CP, Olson DA, Branscum AJ, Iwaniec UT.

J Endocrinol. 2014 Oct;223(1):M1-15. doi: 10.1530/JOE-14-0224. Epub 2014 Jul 2.


Role of estrogen receptor signaling in skeletal response to leptin in female ob/ob mice.

Turner RT, Philbrick KA, Kuah AF, Branscum AJ, Iwaniec UT.

J Endocrinol. 2017 Jun;233(3):357-367. doi: 10.1530/JOE-17-0103. Epub 2017 Apr 20.


Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lep(ob/ob) Mice.

Bolze F, Morath V, Bast A, Rink N, Schlapschy M, Mocek S, Skerra A, Klingenspor M.

Endocrinology. 2016 Jan;157(1):233-44. doi: 10.1210/en.2015-1519. Epub 2015 Oct 22.


Effects of subcutaneous leptin injections on hypothalamic gene profiles in lean and ob/ob mice.

Duan J, Choi YH, Hartzell D, Della-Fera MA, Hamrick M, Baile CA.

Obesity (Silver Spring). 2007 Nov;15(11):2624-33.


Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets.

Lindenmaier LB, Philbrick KA, Branscum AJ, Kalra SP, Turner RT, Iwaniec UT.

Front Endocrinol (Lausanne). 2016 Aug 16;7:110. doi: 10.3389/fendo.2016.00110. eCollection 2016.


Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line.

Luque RM, Kineman RD, Tena-Sempere M.

Endocrinology. 2007 Oct;148(10):4601-11. Epub 2007 Jun 26.


Increased expression of transthyretin in leptin-deficient ob/ob mice is not causative for their major phenotypic abnormalities.

Rendenbach C, Ganswindt S, Seitz S, Barvencik F, Huebner AK, Baranowsky A, Streichert T, Niemeier A, Heeren J, Amling M, Bartelt A, Schinke T.

J Neuroendocrinol. 2013 Jan;25(1):14-22. doi: 10.1111/j.1365-2826.2012.02366.x.


Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS.

Li J, Wei D, McCrory MA, Szalai AJ, Yang G, Li L, Li F, Zhao AZ.

Biochem J. 2016 May 1;473(9):1215-24. doi: 10.1042/BJ20151282. Epub 2016 Mar 1.


Leptin rapidly lowers food intake and elevates metabolic rates in lean and ob/ob mice.

Mistry AM, Swick AG, Romsos DR.

J Nutr. 1997 Oct;127(10):2065-72.


Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay.

Kalra SP, Dube MG, Iwaniec UT.

Peptides. 2009 May;30(5):967-73. doi: 10.1016/j.peptides.2009.01.020. Epub 2009 Feb 7.


Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change.

Dhillon H, Ge Y, Minter RM, Prima V, Moldawer LL, Muzyczka N, Zolotukhin S, Kalra PS, Kalra SP.

Regul Pept. 2000 Aug 25;92(1-3):97-105.


Effects of chronic murine and human leptin infusion on plasma leptin and corticosterone levels and energy balance in lean Zucker rats.

Al-Barazanji KA, Buckingham RE, Arch JR, Briscoe C, Jenkins O, Tadayyon M.

Diabetes Obes Metab. 2001 Dec;3(6):435-42.


Hepatic gene expression profiling reveals key pathways involved in leptin-mediated weight loss in ob/ob mice.

Sharma A, Bartell SM, Baile CA, Chen B, Podolsky RH, McIndoe RA, She JX.

PLoS One. 2010 Aug 16;5(8):e12147. doi: 10.1371/journal.pone.0012147.

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