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Items: 1 to 20 of 108

1.

HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes.

Zhu Z, Tran H, Mathahs MM, Moninger TO, Schmidt WN.

PLoS One. 2017 Jan 5;12(1):e0166853. doi: 10.1371/journal.pone.0166853. eCollection 2017.

2.

Hepatitis C virus core protein enhances Telomerase activity in Huh7 cells.

Zhu Z, Wilson AT, Gopalakrishna K, Brown KE, Luxon BA, Schmidt WN.

J Med Virol. 2010 Feb;82(2):239-48. doi: 10.1002/jmv.21644.

PMID:
20029802
3.

Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.

Kalkeri G, Lin C, Gopilan J, Sloan K, Rijnbrand R, Kwong AD.

Antimicrob Agents Chemother. 2013 Sep;57(9):4417-26. doi: 10.1128/AAC.00399-13. Epub 2013 Jul 8.

4.
5.

Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors.

Li YP, Ramirez S, Humes D, Jensen SB, Gottwein JM, Bukh J.

Gastroenterology. 2014 Mar;146(3):812-821.e4. doi: 10.1053/j.gastro.2013.11.009. Epub 2013 Nov 18.

PMID:
24262279
6.

Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle.

McGivern DR, Masaki T, Lovell W, Hamlett C, Saalau-Bethell S, Graham B.

J Virol. 2015 May;89(10):5362-70. doi: 10.1128/JVI.03188-14. Epub 2015 Mar 4.

7.

Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense.

Johnson CL, Owen DM, Gale M Jr.

J Biol Chem. 2007 Apr 6;282(14):10792-803. Epub 2007 Feb 8.

8.

[Effect of hepatitis C virus nonstructural protein NS3 on telomerase activity].

Ouyang X, Cheng R, Feng D, Zheng H.

Zhonghua Bing Li Xue Za Zhi. 2001 Dec;30(6):443-7. Chinese.

PMID:
11866988
9.

The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.

Aydin C, Mukherjee S, Hanson AM, Frick DN, Schiffer CA.

Protein Sci. 2013 Dec;22(12):1786-98. doi: 10.1002/pro.2378. Epub 2013 Oct 19.

10.

Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease.

Jouan L, Melançon P, Rodrigue-Gervais IG, Raymond VA, Selliah S, Boucher G, Bilodeau M, Grandvaux N, Lamarre D.

J Hepatol. 2010 Feb;52(2):167-75. doi: 10.1016/j.jhep.2009.11.011. Epub 2009 Nov 27.

PMID:
20006398
11.

Inhibition of protease-inhibitor-resistant hepatitis C virus replicons and infectious virus by intracellular intrabodies.

Gal-Tanamy M, Zemel R, Bachmatov L, Jangra RK, Shapira A, Villanueva RA, Yi M, Lemon SM, Benhar I, Tur-Kaspa R.

Antiviral Res. 2010 Oct;88(1):95-106. doi: 10.1016/j.antiviral.2010.08.001. Epub 2010 Aug 10.

12.

A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target.

Schiering N, D'Arcy A, Villard F, Simic O, Kamke M, Monnet G, Hassiepen U, Svergun DI, Pulfer R, Eder J, Raman P, Bodendorf U.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21052-6. doi: 10.1073/pnas.1110534108. Epub 2011 Dec 12.

13.

A wide range of NS3/4A protease catalytic efficiencies in HCV-infected individuals.

Franco S, Clotet B, Martínez MA.

Virus Res. 2008 Feb;131(2):260-70. Epub 2007 Nov 26.

PMID:
18037183
14.

The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.

Prikhod'ko EA, Prikhod'ko GG, Siegel RM, Thompson P, Major ME, Cohen JI.

Virology. 2004 Nov 10;329(1):53-67.

15.

HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression.

Shiu TY, Shih YL, Feng AC, Lin HH, Huang SM, Huang TY, Hsieh CB, Chang WK, Hsieh TY.

J Mol Med (Berl). 2017 Jun;95(6):629-639. doi: 10.1007/s00109-017-1518-4. Epub 2017 Mar 3.

PMID:
28258280
16.

Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells.

Hou W, Tian Q, Zheng J, Bonkovsky HL.

Gastroenterology. 2010 May;138(5):1909-19. doi: 10.1053/j.gastro.2009.11.001. Epub 2009 Nov 10.

17.

Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression.

Kaukinen P, Sillanpää M, Kotenko S, Lin R, Hiscott J, Melén K, Julkunen I.

Virol J. 2006 Sep 1;3:66.

18.

Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.

Mawatari S, Uto H, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H.

PLoS One. 2013 Dec 12;8(12):e82094. doi: 10.1371/journal.pone.0082094. eCollection 2013.

19.

Hepatitis C virus NS3 protein modulates the biological behaviors of malignant hepatocytes by altering the expression of host cell microRNA.

Zhang J, Ishigaki Y, Takegami T.

Mol Med Rep. 2015 Oct;12(4):5109-15. doi: 10.3892/mmr.2015.4041. Epub 2015 Jul 3.

PMID:
26151503
20.

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