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Items: 1 to 20 of 108

1.

Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.

Polanco MJ, Parodi S, Piol D, Stack C, Chivet M, Contestabile A, Miranda HC, Lievens PM, Espinoza S, Jochum T, Rocchi A, Grunseich C, Gainetdinov RR, Cato AC, Lieberman AP, La Spada AR, Sambataro F, Fischbeck KH, Gozes I, Pennuto M.

Sci Transl Med. 2016 Dec 21;8(370):370ra181. doi: 10.1126/scitranslmed.aaf9526.

PMID:
28003546
2.

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.

Chua JP, Reddy SL, Yu Z, Giorgetti E, Montie HL, Mukherjee S, Higgins J, McEachin RC, Robins DM, Merry DE, Iñiguez-Lluhí JA, Lieberman AP.

J Clin Invest. 2015 Feb;125(2):831-45. doi: 10.1172/JCI73214. Epub 2015 Jan 20.

3.

Altered ionic currents and amelioration by IGF-1 and PACAP in motoneuron-derived cells modelling SBMA.

Jiménez Garduño AM, Juárez-Hernández LJ, Polanco MJ, Tosatto L, Michelatti D, Arosio D, Basso M, Pennuto M, Musio C.

Biophys Chem. 2017 Oct;229:68-76. doi: 10.1016/j.bpc.2017.05.003. Epub 2017 May 10.

PMID:
28511915
4.

Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.

Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR.

J Neurosci. 2009 Feb 18;29(7):1987-97. doi: 10.1523/JNEUROSCI.4072-08.2009.

5.

Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.

Scaramuzzino C, Casci I, Parodi S, Lievens PMJ, Polanco MJ, Milioto C, Chivet M, Monaghan J, Mishra A, Badders N, Aggarwal T, Grunseich C, Sambataro F, Basso M, Fackelmayer FO, Taylor JP, Pandey UB, Pennuto M.

Neuron. 2015 Jan 7;85(1):88-100. doi: 10.1016/j.neuron.2014.12.031.

6.

Fighting polyglutamine disease by wrestling with SUMO.

Craig TJ, Henley JM.

J Clin Invest. 2015 Feb;125(2):498-500. doi: 10.1172/JCI80278. Epub 2015 Jan 20.

7.

Disruption of nongenomic testosterone signaling in a model of spinal and bulbar muscular atrophy.

Schindler M, Fabre C, de Weille J, Carreau S, Mersel M, Bakalara N.

Mol Endocrinol. 2012 Jul;26(7):1102-16. doi: 10.1210/me.2011-1367. Epub 2012 May 8.

8.

Inhibition of the Androgen Receptor by Antiandrogens in Spinobulbar Muscle Atrophy.

Baniahmad A.

J Mol Neurosci. 2016 Mar;58(3):343-7. doi: 10.1007/s12031-015-0681-8. Epub 2015 Nov 12. Review.

PMID:
26563449
9.

Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy.

Thomas PS Jr, Fraley GS, Damian V, Woodke LB, Zapata F, Sopher BL, Plymate SR, La Spada AR.

Hum Mol Genet. 2006 Jul 15;15(14):2225-38. Epub 2006 Jun 13. Erratum in: Hum Mol Genet. 2006 Oct 1;15(19):2972. Damien, Vincent [corrected to Damian, Vincent].

PMID:
16772330
10.

Neurodegenerative disease: Pituitary adenylate cyclase activator ameliorates SBMA.

Crunkhorn S.

Nat Rev Drug Discov. 2017 Feb 2;16(2):88. doi: 10.1038/nrd.2017.11. No abstract available.

PMID:
28148932
11.

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.

Montie HL, Pestell RG, Merry DE.

J Neurosci. 2011 Nov 30;31(48):17425-36. doi: 10.1523/JNEUROSCI.3958-11.2011.

12.
13.

Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.

Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL.

Endocrinology. 2014 Jul;155(7):2624-34. doi: 10.1210/en.2013-1756. Epub 2014 Apr 17.

14.

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP.

Nat Chem Biol. 2013 Feb;9(2):112-8. doi: 10.1038/nchembio.1140. Epub 2012 Dec 9.

15.

p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Tohnai G, Qiang Q, Tanaka F, Yanagawa T, Warabi E, Ishii T, Sobue G.

J Neurosci. 2013 May 1;33(18):7710-27. doi: 10.1523/JNEUROSCI.3021-12.2013.

16.

Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy.

Nihei Y, Ito D, Okada Y, Akamatsu W, Yagi T, Yoshizaki T, Okano H, Suzuki N.

J Biol Chem. 2013 Mar 22;288(12):8043-52. doi: 10.1074/jbc.M112.408211. Epub 2013 Jan 30.

17.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

18.

Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity.

Suzuki E, Zhao Y, Ito S, Sawatsubashi S, Murata T, Furutani T, Shirode Y, Yamagata K, Tanabe M, Kimura S, Ueda T, Fujiyama S, Lim J, Matsukawa H, Kouzmenko AP, Aigaki T, Tabata T, Takeyama K, Kato S.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3818-22. doi: 10.1073/pnas.0809819106. Epub 2009 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16393.

19.

X-Linked Spinal and Bulbar Muscular Atrophy: From Clinical Genetic Features and Molecular Pathology to Mechanisms Underlying Disease Toxicity.

Cortes CJ, La Spada AR.

Adv Exp Med Biol. 2018;1049:103-133. doi: 10.1007/978-3-319-71779-1_5. Review.

PMID:
29427100
20.

Mechanisms mediating spinal and bulbar muscular atrophy: investigations into polyglutamine-expanded androgen receptor function and dysfunction.

Beitel LK, Alvarado C, Mokhtar S, Paliouras M, Trifiro M.

Front Neurol. 2013 May 15;4:53. doi: 10.3389/fneur.2013.00053. eCollection 2013.

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