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Caspase-2-mediated cell death is required for deleting aneuploid cells.

Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S.

Oncogene. 2017 May 11;36(19):2704-2714. doi: 10.1038/onc.2016.423. Epub 2016 Dec 19.


Caspase-2 protects against oxidative stress in vivo.

Shalini S, Puccini J, Wilson CH, Finnie J, Dorstyn L, Kumar S.

Oncogene. 2015 Sep 17;34(38):4995-5002. doi: 10.1038/onc.2014.413. Epub 2014 Dec 22.


Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.

Puccini J, Shalini S, Voss AK, Gatei M, Wilson CH, Hiwase DK, Lavin MF, Dorstyn L, Kumar S.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19920-5. doi: 10.1073/pnas.1311947110. Epub 2013 Nov 18.


Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.

Dawar S, Shahrin NH, Sladojevic N, D'Andrea RJ, Dorstyn L, Hiwase DK, Kumar S.

Cell Death Dis. 2016 Dec 1;7(12):e2509. doi: 10.1038/cddis.2016.406.


Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.

Dorstyn L, Puccini J, Wilson CH, Shalini S, Nicola M, Moore S, Kumar S.

Cell Death Differ. 2012 Aug;19(8):1288-98. doi: 10.1038/cdd.2012.36. Epub 2012 Apr 13. Erratum in: Cell Death Differ. 2012 Aug;19(8):1411.


Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice.

Shalini S, Dorstyn L, Wilson C, Puccini J, Ho L, Kumar S.

Cell Death Differ. 2012 Aug;19(8):1370-80. doi: 10.1038/cdd.2012.13. Epub 2012 Feb 17.


Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.

Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DR.

Cell Death Differ. 2013 Sep;20(9):1174-82. doi: 10.1038/cdd.2013.38. Epub 2013 May 3.


A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.

Tiwari M, Sharma LK, Vanegas D, Callaway DA, Bai Y, Lechleiter JD, Herman B.

Autophagy. 2014 Jun;10(6):1054-70. doi: 10.4161/auto.28528.


Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal.

Vigneswara V, Berry M, Logan A, Ahmed Z.

PLoS One. 2013;8(2):e57861. doi: 10.1371/journal.pone.0057861. Epub 2013 Feb 25.


Caspase-2 as a tumour suppressor.

Puccini J, Dorstyn L, Kumar S.

Cell Death Differ. 2013 Sep;20(9):1133-9. doi: 10.1038/cdd.2013.87. Epub 2013 Jun 28. Review.


Caspase-2 deficiency enhances aging-related traits in mice.

Zhang Y, Padalecki SS, Chaudhuri AR, De Waal E, Goins BA, Grubbs B, Ikeno Y, Richardson A, Mundy GR, Herman B.

Mech Ageing Dev. 2007 Feb;128(2):213-21. Epub 2006 Dec 22.


Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.

Sharma R, Callaway D, Vanegas D, Bendele M, Lopez-Cruzan M, Horn D, Guda T, Fajardo R, Abboud-Werner S, Herman B.

PLoS One. 2014 Apr 1;9(4):e93696. doi: 10.1371/journal.pone.0093696. eCollection 2014.


An unexpected role for caspase-2 in neuroblastoma.

Dorstyn L, Puccini J, Nikolic A, Shalini S, Wilson CH, Norris MD, Haber M, Kumar S.

Cell Death Dis. 2014 Aug 21;5:e1383. doi: 10.1038/cddis.2014.342.


Caspase-2 deficiency accelerates chemically induced liver cancer in mice.

Shalini S, Nikolic A, Wilson CH, Puccini J, Sladojevic N, Finnie J, Dorstyn L, Kumar S.

Cell Death Differ. 2016 Oct;23(10):1727-36. doi: 10.1038/cdd.2016.81. Epub 2016 Aug 12.


Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury.

Carlsson Y, Schwendimann L, Vontell R, Rousset CI, Wang X, Lebon S, Charriaut-Marlangue C, Supramaniam V, Hagberg H, Gressens P, Jacotot E.

Ann Neurol. 2011 Nov;70(5):781-9. doi: 10.1002/ana.22431. Epub 2011 Jun 14.


Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species.

Lopez-Cruzan M, Herman B.

Biogerontology. 2013 Apr;14(2):121-30. doi: 10.1007/s10522-013-9415-x. Epub 2013 Mar 16.


Low level chromosome instability in embryonic cells of primary aneuploid mice.

Lightfoot DA, Höög C.

Cytogenet Genome Res. 2004;107(1-2):95-8.


Gene mutations and aneuploidy: the instability that causes cancer.

Woo RA, Poon RY.

Cell Cycle. 2004 Sep;3(9):1101-3. Epub 2004 Sep 15. Review.


Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.

Vigneswara V, Akpan N, Berry M, Logan A, Troy CM, Ahmed Z.

Brain. 2014 Jun;137(Pt 6):1656-75. doi: 10.1093/brain/awu037. Epub 2014 Apr 10.


Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.

Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J.

J Neurosci. 2012 Nov 14;32(46):16213-22. doi: 10.1523/JNEUROSCI.3706-12.2012.

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