Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 97

1.

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J.

Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15.

2.

Senescent cells: New target for an old treatment?

Demaria M.

Mol Cell Oncol. 2017 Apr 3;4(3):e1299666. doi: 10.1080/23723556.2017.1299666. eCollection 2017.

3.

Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.

Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, Rudolph KL, Sharpless NE, Muss HB.

J Natl Cancer Inst. 2014 Apr;106(4):dju057. doi: 10.1093/jnci/dju057. Epub 2014 Mar 28.

4.

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice.

Was H, Barszcz K, Czarnecka J, Kowalczyk A, Bernas T, Uzarowska E, Koza P, Klejman A, Piwocka K, Kaminska B, Sikora E.

Oncotarget. 2017 Feb 7;8(6):9303-9322. doi: 10.18632/oncotarget.14066.

5.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

6.

Identification of Senescent Cells in the Bone Microenvironment.

Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892. Epub 2016 Oct 24.

7.

Distinct phenotypes and 'bystander' effects of senescent tumour cells induced by docetaxel or immunomodulatory cytokines.

Sapega O, Mikyšková R, Bieblová J, Mrázková B, Hodný Z, Reiniš M.

Int J Oncol. 2018 Nov;53(5):1997-2009. doi: 10.3892/ijo.2018.4553. Epub 2018 Sep 5.

8.

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

Wang R, Yu Z, Sunchu B, Shoaf J, Dang I, Zhao S, Caples K, Bradley L, Beaver LM, Ho E, Löhr CV, Perez VI.

Aging Cell. 2017 Jun;16(3):564-574. doi: 10.1111/acel.12587. Epub 2017 Mar 31.

9.

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J.

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.

10.

p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.

Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I.

Nat Med. 2016 Apr;22(4):412-20. doi: 10.1038/nm.4054. Epub 2016 Mar 7.

11.

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.

Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J, Andò S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Oct 1;11(19):3599-610. doi: 10.4161/cc.21884. Epub 2012 Aug 30.

12.

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin II, Leonova KI, Consiglio CR, Gollnick SO, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Aug 2;9(8):1867-1884. doi: 10.18632/aging.101268.

13.

Senescence-associated reprogramming promotes cancer stemness.

Milanovic M, Fan DNY, Belenki D, Däbritz JHM, Zhao Z, Yu Y, Dörr JR, Dimitrova L, Lenze D, Monteiro Barbosa IA, Mendoza-Parra MA, Kanashova T, Metzner M, Pardon K, Reimann M, Trumpp A, Dörken B, Zuber J, Gronemeyer H, Hummel M, Dittmar G, Lee S, Schmitt CA.

Nature. 2018 Jan 4;553(7686):96-100. doi: 10.1038/nature25167. Epub 2017 Dec 20.

PMID:
29258294
14.

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.

Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI, Cater MA.

Redox Biol. 2018 Apr;14:100-115. doi: 10.1016/j.redox.2017.08.015. Epub 2017 Sep 1.

15.

Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107.

Khor ES, Wong PF.

Int J Biochem Cell Biol. 2018 Aug;101:64-73. doi: 10.1016/j.biocel.2018.05.016. Epub 2018 May 29.

PMID:
29857052
16.

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH.

Nat Med. 2017 Jun;23(6):775-781. doi: 10.1038/nm.4324. Epub 2017 Apr 24.

17.

Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.

Frescas D, Hall BM, Strom E, Virtuoso LP, Gupta M, Gleiberman AS, Rydkina E, Balan V, Vujcic S, Chernova OB, Gudkov AV.

Cell Cycle. 2017 Aug 18;16(16):1526-1533. doi: 10.1080/15384101.2017.1339850. Epub 2017 Jun 26.

18.

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.

Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin I, Leonova K, Polinsky A, Chernova OB, Gudkov AV.

Aging (Albany NY). 2016 Jul;8(7):1294-315. doi: 10.18632/aging.100991.

19.

Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth.

Guan X, LaPak KM, Hennessey RC, Yu CY, Shakya R, Zhang J, Burd CE.

Mol Cancer Res. 2017 Mar;15(3):237-249. doi: 10.1158/1541-7786.MCR-16-0319. Epub 2016 Dec 30.

20.

Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes.

Cotarelo CL, Schad A, Kirkpatrick CJ, Sleeman JP, Springer E, Schmidt M, Thaler S.

Oncotarget. 2016 Nov 15;7(46):74846-74859. doi: 10.18632/oncotarget.12432.

Supplemental Content

Support Center