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Items: 1 to 20 of 96

1.

Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.

Garcia-Rua V, Feijoo-Bandin S, Garcia-Vence M, Aragon-Herrera A, Bravo SB, Rodriguez-Penas D, Mosquera-Leal A, Lear PV, Parrington J, Alonso J, Rosello-Lleti E, Portoles M, Rivera M, Gonzalez-Juanatey JR, Lago F.

J Biosci. 2016 Dec;41(4):643-658.

2.

Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.

García-Rúa V, Feijóo-Bandín S, Rodríguez-Penas D, Mosquera-Leal A, Abu-Assi E, Beiras A, María Seoane L, Lear P, Parrington J, Portolés M, Roselló-Lletí E, Rivera M, Gualillo O, Parra V, Hill JA, Rothermel B, González-Juanatey JR, Lago F.

J Physiol. 2016 Jun 1;594(11):3061-77. doi: 10.1113/JP271332. Epub 2016 Feb 4.

3.

Increased expression of fatty-acid and calcium metabolism genes in failing human heart.

García-Rúa V, Otero MF, Lear PV, Rodríguez-Penas D, Feijóo-Bandín S, Noguera-Moreno T, Calaza M, Álvarez-Barredo M, Mosquera-Leal A, Parrington J, Brugada J, Portolés M, Rivera M, González-Juanatey JR, Lago F.

PLoS One. 2012;7(6):e37505. doi: 10.1371/journal.pone.0037505. Epub 2012 Jun 6.

4.

Two-pore channels and disease.

Patel S, Kilpatrick BS.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1678-1686. doi: 10.1016/j.bbamcr.2018.05.004. Epub 2018 May 7. Review.

5.

Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.

Lear PV, González-Touceda D, Porteiro Couto B, Viaño P, Guymer V, Remzova E, Tunn R, Chalasani A, García-Caballero T, Hargreaves IP, Tynan PW, Christian HC, Nogueiras R, Parrington J, Diéguez C.

Endocrinology. 2015 Mar;156(3):975-86. doi: 10.1210/en.2014-1766. Epub 2014 Dec 29.

6.

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Ruas M, Davis LC, Chen CC, Morgan AJ, Chuang KT, Walseth TF, Grimm C, Garnham C, Powell T, Platt N, Platt FM, Biel M, Wahl-Schott C, Parrington J, Galione A.

EMBO J. 2015 Jul 2;34(13):1743-58. doi: 10.15252/embj.201490009. Epub 2015 Apr 14.

7.
8.

Altered mRNA abundance of calcium transport genes in cardiac myocytes induced by angiotensin II.

Ju H, Scammel-La Fleur T, Dixon IM.

J Mol Cell Cardiol. 1996 May;28(5):1119-28.

PMID:
8762048
9.

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H.

Cell. 2012 Oct 12;151(2):372-83. doi: 10.1016/j.cell.2012.08.036.

10.

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J.

Mol Cell Biol. 2014 Nov;34(21):3981-92. doi: 10.1128/MCB.00113-14. Epub 2014 Aug 18.

11.

Targeted GLUT-4 deficiency in the heart induces cardiomyocyte hypertrophy and impaired contractility linked with Ca(2+) and proton flux dysregulation.

Domenighetti AA, Danes VR, Curl CL, Favaloro JM, Proietto J, Delbridge LM.

J Mol Cell Cardiol. 2010 Apr;48(4):663-72. doi: 10.1016/j.yjmcc.2009.11.017. Epub 2009 Dec 3.

PMID:
19962383
12.

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart.

Yang H, Feng A, Lin S, Yu L, Lin X, Yan X, Lu X, Zhang C.

Cell Death Dis. 2018 Feb 14;9(2):227. doi: 10.1038/s41419-018-0307-5.

13.

Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking.

Ramírez E, Picatoste B, González-Bris A, Oteo M, Cruz F, Caro-Vadillo A, Egido J, Tuñón J, Morcillo MA, Lorenzo Ó.

Cardiovasc Diabetol. 2018 Jan 11;17(1):12. doi: 10.1186/s12933-017-0643-2.

14.

Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice.

Nakatani K, Masuda D, Kobayashi T, Sairyo M, Zhu Y, Okada T, Naito AT, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Yamashita S.

Int Heart J. 2019 Jan 25;60(1):159-167. doi: 10.1536/ihj.18-114. Epub 2018 Dec 5.

15.

Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements.

Armoni M, Harel C, Bar-Yoseph F, Milo S, Karnieli E.

J Biol Chem. 2005 Oct 14;280(41):34786-95. Epub 2005 Aug 10.

16.

Regulated and aberrant glycosylation modulate cardiac electrical signaling.

Montpetit ML, Stocker PJ, Schwetz TA, Harper JM, Norring SA, Schaffer L, North SJ, Jang-Lee J, Gilmartin T, Head SR, Haslam SM, Dell A, Marth JD, Bennett ES.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16517-22. doi: 10.1073/pnas.0905414106. Epub 2009 Aug 7.

17.

Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart.

Howarth FC, Qureshi MA, Hassan Z, Al Kury LT, Isaev D, Parekh K, Yammahi SR, Oz M, Adrian TE, Adeghate E.

Exp Physiol. 2011 Mar;96(3):325-37. doi: 10.1113/expphysiol.2010.055574. Epub 2011 Jan 7.

18.

Regulation and dysregulation of glucose transport in cardiomyocytes.

Montessuit C, Lerch R.

Biochim Biophys Acta. 2013 Apr;1833(4):848-56. doi: 10.1016/j.bbamcr.2012.08.009. Epub 2012 Aug 17. Review.

19.

A single bout of exercise increases the expression of glucose but not fatty acid transporters in skeletal muscle of IL-6 KO mice.

Lukaszuk B, Bialuk I, Górski J, Zajączkiewicz M, Winnicka MM, Chabowski A.

Lipids. 2012 Aug;47(8):763-72. doi: 10.1007/s11745-012-3678-x. Epub 2012 May 24.

20.

Alteration of cardiac glucose metabolism in association to low birth weight: experimental evidence in lambs with left ventricular hypertrophy.

Wang KC, Lim CH, McMillen IC, Duffield JA, Brooks DA, Morrison JL.

Metabolism. 2013 Nov;62(11):1662-72. doi: 10.1016/j.metabol.2013.06.013. Epub 2013 Aug 5.

PMID:
23928106

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