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Items: 1 to 20 of 121

1.

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM.

Sci Signal. 2016 Nov 8;9(453):ra109.

2.

Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.

Zhu YP, Brown JR, Sag D, Zhang L, Suttles J.

J Immunol. 2015 Jan 15;194(2):584-94. doi: 10.4049/jimmunol.1401024. Epub 2014 Dec 15.

3.

Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.

Zhang Y, Turkson J, Carter-Su C, Smithgall T, Levitzki A, Kraker A, Krolewski JJ, Medveczky P, Jove R.

J Biol Chem. 2000 Aug 11;275(32):24935-44.

4.

Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.

Hornakova T, Staerk J, Royer Y, Flex E, Tartaglia M, Constantinescu SN, Knoops L, Renauld JC.

J Biol Chem. 2009 Mar 13;284(11):6773-81. doi: 10.1074/jbc.M807531200. Epub 2009 Jan 12.

6.

The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation.

Iwamoto T, Senga T, Naito Y, Matsuda S, Miyake Y, Yoshimura A, Hamaguchi M.

Oncogene. 2000 Sep 28;19(41):4795-801.

7.

Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.

Chen J, Zhang Y, Petrus MN, Xiao W, Nicolae A, Raffeld M, Pittaluga S, Bamford RN, Nakagawa M, Ouyang ST, Epstein AL, Kadin ME, Del Mistro A, Woessner R, Jaffe ES, Waldmann TA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3975-3980. doi: 10.1073/pnas.1700682114. Epub 2017 Mar 29.

8.
9.

LIF-JAK1-STAT3 signaling delays contact inhibition of human corneal endothelial cells.

Liu X, Tseng SC, Zhang MC, Chen SY, Tighe S, Lu WJ, Zhu YT.

Cell Cycle. 2015;14(8):1197-206. doi: 10.1080/15384101.2015.1013667.

10.

Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway.

Lin CC, Yeh HH, Huang WL, Yan JJ, Lai WW, Su WP, Chen HH, Su WC.

Am J Respir Cell Mol Biol. 2013 Aug;49(2):241-50. doi: 10.1165/rcmb.2012-0244OC.

PMID:
23526220
11.

Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation.

Zhu H, Moriasi CM, Zhang M, Zhao Y, Zou MH.

J Biol Chem. 2013 Jun 7;288(23):16495-505. doi: 10.1074/jbc.M112.443580. Epub 2013 Apr 23.

12.

Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.

Aparicio-Siegmund S, Sommer J, Monhasery N, Schwanbeck R, Keil E, Finkenstädt D, Pfeffer K, Rose-John S, Scheller J, Garbers C.

Oncotarget. 2014 Apr 30;5(8):2131-48.

13.

Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation.

Boyle K, Zhang JG, Nicholson SE, Trounson E, Babon JJ, McManus EJ, Nicola NA, Robb L.

Cell Signal. 2009 Mar;21(3):394-404. doi: 10.1016/j.cellsig.2008.11.002. Epub 2008 Nov 12.

14.

Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?

Speirs C, Williams JJL, Riches K, Salt IP, Palmer TM.

Pharmacol Res. 2018 Feb;128:88-100. doi: 10.1016/j.phrs.2017.10.001. Epub 2017 Oct 13. Review.

PMID:
29037480
15.

JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling.

Song L, Rawal B, Nemeth JA, Haura EB.

Mol Cancer Ther. 2011 Mar;10(3):481-94. doi: 10.1158/1535-7163.MCT-10-0502. Epub 2011 Jan 7.

16.

JAK1-mediated Sirt1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway.

Wang W, Li F, Xu Y, Wei J, Zhang Y, Yang H, Gao B, Yu G, Fang D.

J Biol Chem. 2018 Jul 13;293(28):11067-11075. doi: 10.1074/jbc.RA117.001387. Epub 2018 May 22.

17.

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

Nerstedt A, Johansson A, Andersson CX, Cansby E, Smith U, Mahlapuu M.

Diabetologia. 2010 Nov;53(11):2406-16. doi: 10.1007/s00125-010-1856-z. Epub 2010 Jul 24.

PMID:
20652679
18.

CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.

Zhang WN, Wang L, Wang Q, Luo X, Fang DF, Chen Y, Pan X, Man JH, Xia Q, Jin BF, Li WH, Li T, Liang B, Chen L, Gong WL, Yu M, Li AL, Zhou T, Li HY.

J Biol Chem. 2012 Jan 2;287(1):382-92. doi: 10.1074/jbc.M111.276832. Epub 2011 Nov 14.

19.

Survival response of hippocampal neurons under low oxygen conditions induced by Hippophae rhamnoides is associated with JAK/STAT signaling.

Manickam M, Tulsawani R.

PLoS One. 2014 Feb 6;9(2):e87694. doi: 10.1371/journal.pone.0087694. eCollection 2014.

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