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3977118,32256685,32431145,24465147,31784610,12196140,27389717,8817545,26452729,30361088,28814675,29722325,20017949,32758420,31308505,36883266,9329695,24093060,24086624,35754278,15484697,35704250,12566180,33348925,37113314,31058201,26136681,32210783,20429127,21672703,8914975,9185677,35932935,12392769,19096165,32844283,26716196,21424161,8474224,27262026,30678343,32775596,30464477,33776435,36873999,8031874,22302811,34650426,34901820,27047372,29491833,9113199,31794135,29955650,28798664,30155107,29423001,31398804,12480764,27378912,35862308,34769316,22860173,33562625,33400461,34751669,22685625,34959868,11409436,33123145,37033452,29522862,29805908,7968239,35579273,33188924,16686956,32779267,21044348,31417399,12214064,34489680,31571648,26316985,27478623,31314409,29134111,35489824,34493703,31737188,7746469,27928512,23741624,33328952,31031595,20478062,34977364,36590474,30574044,15163359,32194368,25926771,25999850,27064204,12677216,25191216,8469414,32654112,24725331,28879426,21371785,2292979,7484088,28782443,27411638,18485104,35470138,33967797,35414980,9779185,32954020,25052558,29402930,33284631,25244580,35721913,36672558,8710175,9712734,32576699,25119777,24987466,28548105,30741684,32508799,36189373,35929392,30598503,27497733,16116239,28670089,23212279,22194817,36551947,30890928,29619173,32806077,33005703,21139807,27239286,31611836,34692095,35233527,19273318,31452991,18784809,36049371,30023962,26531866,30854958,31324853,23717280,33145443,14999905,33035662,30946049,16323353,36872299,37035915,21876828,24959143,30996991,22712003,23840405,26131110,29805885,28507518,21603239,21524667,21912744,15980616,10675914,24841744,35014983,21784348,24581702,21247479,25477959,29180684,34532568,25356391,30483207,31616241,36275414,22737039,9600201,30980949,19202630,24175174,27761145,34735035,30480238,22216132,12847570,33816760,28184195,37127299,23060797,29685068,26344748,36416864,32792510,31259305,24358824,10869339,32641536,35656119,12392767,1975805,22145082,16578915,34539357,36382918,36330340,32973484,28516120,32793545,30839069,36849256,27302344,30249674,30249673,36510663,15679924,9008543,30137880,24735982,29568434,32059404,22277511,32783222,1542796,34901904,10434245,34285489,28883786,29634694,22070806,31935998,21533130,1585149,26834630,35751367,31619739,29973883,25692112,32885023,19496236,34784952,25250012,26375001,32320593,12214075,29620074,25175119,22371285,34253415,37117835,22623853,31405901,37076139[uid]

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Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease.

Bruckmann S, Brenn A, Grube M, Niedrig K, Holtfreter S, von Bohlen und Halbach O, Groschup M, Keller M, Vogelgesang S. Bruckmann S, et al. Curr Alzheimer Res. 2017;14(6):656-667. doi: 10.2174/1567205013666161201201227. Curr Alzheimer Res. 2017. PMID: 27915995

Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice.

Petrushina I, Ghochikyan A, Mkrtichyan M, Mamikonyan G, Movsesyan N, Ajdari R, Vasilevko V, Karapetyan A, Lees A, Agadjanyan MG, Cribbs DH. Petrushina I, et al. J Neuroinflammation. 2008 Sep 29;5:42. doi: 10.1186/1742-2094-5-42. J Neuroinflammation. 2008. PMID: 18823564 Free PMC article.

Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease.

Klakotskaia D, Agca C, Richardson RA, Stopa EG, Schachtman TR, Agca Y. Klakotskaia D, et al. PLoS One. 2018 Apr 11;13(4):e0195469. doi: 10.1371/journal.pone.0195469. eCollection 2018. PLoS One. 2018. PMID: 29641600 Free PMC article.

Active Aβ vaccination fails to enhance amyloid clearance in a mouse model of Alzheimer's disease with Aβ42-driven pathology.

Nemirovsky A, Shapiro J, Baron R, Kompaniets A, Monsonego A. Nemirovsky A, et al. J Neuroimmunol. 2012 Jun 15;247(1-2):95-9. doi: 10.1016/j.jneuroim.2012.03.017. Epub 2012 Apr 10. J Neuroimmunol. 2012. PMID: 22498096

CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.

Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J. Obregon D, et al. Neurobiol Dis. 2008 Feb;29(2):336-53. doi: 10.1016/j.nbd.2007.09.009. Epub 2007 Oct 16. Neurobiol Dis. 2008. PMID: 18055209 Free PMC article.

Active immunization with the peptide epitope vaccine Aβ3-10-KLH induces a Th2-polarized anti-Aβ antibody response and decreases amyloid plaques in APP/PS1 transgenic mice.

Ding L, Meng Y, Zhang HY, Yin WC, Yan Y, Cao YP. Ding L, et al. Neurosci Lett. 2016 Nov 10;634:1-6. doi: 10.1016/j.neulet.2016.09.050. Epub 2016 Sep 28. Neurosci Lett. 2016. PMID: 27693663

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA. Boche D, et al. Brain. 2008 Dec;131(Pt 12):3299-310. doi: 10.1093/brain/awn261. Epub 2008 Oct 25. Brain. 2008. PMID: 18953056 Clinical Trial.

Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice.

Wang J, Li N, Ma J, Gu Z, Yu L, Fu X, Liu X, Wang J. Wang J, et al. Brain Res. 2016 Mar 15;1635:169-79. doi: 10.1016/j.brainres.2016.01.028. Epub 2016 Jan 25. Brain Res. 2016. PMID: 26820640 Free PMC article.

Prophylactic Vaccine Based on Pyroglutamate-3 Amyloid β Generates Strong Antibody Response and Rescues Cognitive Decline in Alzheimer's Disease Model Mice.

Li G, Hu ZW, Chen PG, Sun ZY, Chen YX, Zhao YF, Li YM. Li G, et al. ACS Chem Neurosci. 2017 Mar 15;8(3):454-459. doi: 10.1021/acschemneuro.6b00336. Epub 2016 Nov 29. ACS Chem Neurosci. 2017. PMID: 28292186

The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.

Collins JM, King AE, Woodhouse A, Kirkcaldie MT, Vickers JC. Collins JM, et al. Exp Neurol. 2015 May;267:219-29. doi: 10.1016/j.expneurol.2015.02.034. Epub 2015 Mar 4. Exp Neurol. 2015. PMID: 25747037

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