Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 110

1.

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.

Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F.

Sci Transl Med. 2016 Nov 23;8(366):366ra162.

PMID:
27881823
2.

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.

Bhattacharya A, Wang Q, Ao H, Shoblock JR, Lord B, Aluisio L, Fraser I, Nepomuceno D, Neff RA, Welty N, Lovenberg TW, Bonaventure P, Wickenden AD, Letavic MA.

Br J Pharmacol. 2013 Oct;170(3):624-40. doi: 10.1111/bph.12314.

3.

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia.

Bhattacharya A, Lord B, Grigoleit JS, He Y, Fraser I, Campbell SN, Taylor N, Aluisio L, O'Connor JC, Papp M, Chrovian C, Carruthers N, Lovenberg TW, Letavic MA.

Neuropsychopharmacology. 2018 Dec;43(13):2586-2596. doi: 10.1038/s41386-018-0141-6. Epub 2018 Jul 9.

PMID:
30026598
4.

Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7.

Hussen J, Düvel A, Koy M, Schuberth HJ.

Dev Comp Immunol. 2012 Oct;38(2):312-20. doi: 10.1016/j.dci.2012.06.004. Epub 2012 Jun 19.

PMID:
22728096
5.

Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.

Gicquel T, Victoni T, Fautrel A, Robert S, Gleonnec F, Guezingar M, Couillin I, Catros V, Boichot E, Lagente V.

Clin Exp Pharmacol Physiol. 2014 Apr;41(4):279-86. doi: 10.1111/1440-1681.12214.

PMID:
24472059
6.

TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.

He Y, Franchi L, Núñez G.

J Immunol. 2013 Jan 1;190(1):334-9. doi: 10.4049/jimmunol.1202737. Epub 2012 Dec 7.

7.

A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334.

Lord B, Ameriks MK, Wang Q, Fourgeaud L, Vliegen M, Verluyten W, Haspeslagh P, Carruthers NI, Lovenberg TW, Bonaventure P, Letavic MA, Bhattacharya A.

Eur J Pharmacol. 2015 Oct 15;765:551-9. doi: 10.1016/j.ejphar.2015.09.026. Epub 2015 Sep 18.

PMID:
26386289
8.

P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy.

Khalafalla MG, Woods LT, Camden JM, Khan AA, Limesand KH, Petris MJ, Erb L, Weisman GA.

J Biol Chem. 2017 Oct 6;292(40):16626-16637. doi: 10.1074/jbc.M117.790741. Epub 2017 Aug 10.

9.

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury.

Savio LEB, de Andrade Mello P, Figliuolo VR, de Avelar Almeida TF, Santana PT, Oliveira SDS, Silva CLM, Feldbrügge L, Csizmadia E, Minshall RD, Longhi MS, Wu Y, Robson SC, Coutinho-Silva R.

J Hepatol. 2017 Oct;67(4):716-726. doi: 10.1016/j.jhep.2017.05.021. Epub 2017 May 26.

10.

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action.

Marques-da-Silva C, Chaves MM, Castro NG, Coutinho-Silva R, Guimaraes MZ.

Br J Pharmacol. 2011 Jul;163(5):912-26. doi: 10.1111/j.1476-5381.2011.01254.x.

11.

Mechanical stress-induced interleukin-1beta expression through adenosine triphosphate/P2X7 receptor activation in human periodontal ligament cells.

Kanjanamekanant K, Luckprom P, Pavasant P.

J Periodontal Res. 2013 Apr;48(2):169-76. doi: 10.1111/j.1600-0765.2012.01517.x. Epub 2012 Aug 8.

PMID:
22881405
12.

N-Alkyl-Substituted Isatins Enhance P2X7 Receptor-Induced Interleukin-1β Release from Murine Macrophages.

Sluyter R, Vine KL.

Mediators Inflamm. 2016;2016:2097219. doi: 10.1155/2016/2097219. Epub 2016 Jul 21.

13.

The evolution of P2X7 antagonists with a focus on CNS indications.

Rech JC, Bhattacharya A, Letavic MA, Savall BM.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3838-45. doi: 10.1016/j.bmcl.2016.06.048. Epub 2016 Jun 30. Review.

PMID:
27426304
14.

Structural basis for subtype-specific inhibition of the P2X7 receptor.

Karasawa A, Kawate T.

Elife. 2016 Dec 9;5. pii: e22153. doi: 10.7554/eLife.22153.

15.

P2X7 receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3/IL-1β pathway.

Yin J, Wang Y, Hu H, Li X, Xue M, Cheng W, Wang Y, Li X, Yang N, Shi Y, Yan S.

J Cell Mol Med. 2017 Nov;21(11):2695-2710. doi: 10.1111/jcmm.13185. Epub 2017 May 4.

16.

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release.

Barberà-Cremades M, Baroja-Mazo A, Gomez AI, Machado F, Di Virgilio F, Pelegrín P.

FASEB J. 2012 Jul;26(7):2951-62. doi: 10.1096/fj.12-205765. Epub 2012 Apr 6.

PMID:
22490780
17.

Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.

Lord B, Aluisio L, Shoblock JR, Neff RA, Varlinskaya EI, Ceusters M, Lovenberg TW, Carruthers N, Bonaventure P, Letavic MA, Deak T, Drinkenburg W, Bhattacharya A.

J Pharmacol Exp Ther. 2014 Dec;351(3):628-41. doi: 10.1124/jpet.114.218487. Epub 2014 Sep 30.

PMID:
25271258
18.

Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7.

Hattori F, Ohshima Y, Seki S, Tsukimoto M, Sato M, Takenouchi T, Suzuki A, Takai E, Kitani H, Harada H, Kojima S.

Eur J Pharmacol. 2012 Nov 15;695(1-3):20-6. doi: 10.1016/j.ejphar.2012.09.001. Epub 2012 Sep 11.

PMID:
22981895
19.

1,4-Naphthoquinones potently inhibiting P2X7 receptor activity.

Faria RX, Oliveira FH, Salles JP, Oliveira AS, von Ranke NL, Bello ML, Rodrigues CR, Castro HC, Louvis AR, Martins DL, Ferreira VF.

Eur J Med Chem. 2018 Jan 1;143:1361-1372. doi: 10.1016/j.ejmech.2017.10.033. Epub 2017 Oct 23.

PMID:
29133043
20.

Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7.

Kaiser M, Sobottka H, Fischer W, Schaefer M, Nörenberg W.

J Pharmacol Exp Ther. 2014 Sep;350(3):531-42. doi: 10.1124/jpet.114.214569. Epub 2014 Jun 26.

PMID:
24970925

Supplemental Content

Support Center