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Items: 1 to 20 of 185

1.

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.

Martin P, McGovern A, Massey J, Schoenfelder S, Duffus K, Yarwood A, Barton A, Worthington J, Fraser P, Eyre S, Orozco G.

PLoS One. 2016 Nov 18;11(11):e0166923. doi: 10.1371/journal.pone.0166923. eCollection 2016.

2.

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

McGovern A, Schoenfelder S, Martin P, Massey J, Duffus K, Plant D, Yarwood A, Pratt AG, Anderson AE, Isaacs JD, Diboll J, Thalayasingam N, Ospelt C, Barton A, Worthington J, Fraser P, Eyre S, Orozco G.

Genome Biol. 2016 Nov 1;17(1):212.

3.

Functional relevance for multiple sclerosis-associated genetic variants.

Lin X, Deng FY, Mo XB, Wu LF, Lei SF.

Immunogenetics. 2015 Jan;67(1):7-14. doi: 10.1007/s00251-014-0803-4. Epub 2014 Oct 12.

PMID:
25308886
4.

Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.

Alcina A, Fedetz M, Fernández O, Saiz A, Izquierdo G, Lucas M, Leyva L, García-León JA, Abad-Grau Mdel M, Alloza I, Antigüedad A, Garcia-Barcina MJ, Vandenbroeck K, Varadé J, de la Hera B, Arroyo R, Comabella M, Montalban X, Petit-Marty N, Navarro A, Otaegui D, Olascoaga J, Blanco Y, Urcelay E, Matesanz F.

J Med Genet. 2013 Jan;50(1):25-33. doi: 10.1136/jmedgenet-2012-101085. Epub 2012 Nov 17.

5.

Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.

Liu Y, Maxwell S, Feng T, Zhu X, Elston RC, Koyutürk M, Chance MR.

BMC Syst Biol. 2012;6 Suppl 3:S15. doi: 10.1186/1752-0509-6-S3-S15. Epub 2012 Dec 17.

6.

Endometrial vezatin and its association with endometriosis risk.

Holdsworth-Carson SJ, Fung JN, Luong HT, Sapkota Y, Bowdler LM, Wallace L, Teh WT, Powell JE, Girling JE, Healey M, Montgomery GW, Rogers PA.

Hum Reprod. 2016 May;31(5):999-1013. doi: 10.1093/humrep/dew047. Epub 2016 Mar 22.

PMID:
27005890
7.

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs.

Ricaño-Ponce I, Zhernakova DV, Deelen P, Luo O, Li X, Isaacs A, Karjalainen J, Di Tommaso J, Borek ZA, Zorro MM, Gutierrez-Achury J, Uitterlinden AG, Hofman A, van Meurs J; BIOS Consortium; Lifelines Cohort Study, Netea MG, Jonkers IH, Withoff S, van Duijn CM, Li Y, Ruan Y, Franke L, Wijmenga C, Kumar V.

J Autoimmun. 2016 Apr;68:62-74. doi: 10.1016/j.jaut.2016.01.002. Epub 2016 Feb 18.

8.

Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.

Dryden NH, Broome LR, Dudbridge F, Johnson N, Orr N, Schoenfelder S, Nagano T, Andrews S, Wingett S, Kozarewa I, Assiotis I, Fenwick K, Maguire SL, Campbell J, Natrajan R, Lambros M, Perrakis E, Ashworth A, Fraser P, Fletcher O.

Genome Res. 2014 Nov;24(11):1854-68. doi: 10.1101/gr.175034.114. Epub 2014 Aug 13.

9.

Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis.

Ragnedda G, Disanto G, Giovannoni G, Ebers GC, Sotgiu S, Ramagopalan SV.

PLoS One. 2012;7(10):e46730. doi: 10.1371/journal.pone.0046730. Epub 2012 Oct 18.

10.

Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility.

Dieguez-Gonzalez R, Calaza M, Perez-Pampin E, Balsa A, Blanco FJ, Cañete JD, Caliz R, Carreño L, de la Serna AR, Fernandez-Gutierrez B, Ortiz AM, Herrero-Beaumont G, Pablos JL, Narvaez J, Navarro F, Marenco JL, Gomez-Reino JJ, Gonzalez A.

Arthritis Res Ther. 2009;11(2):R42. doi: 10.1186/ar2650. Epub 2009 Mar 17.

11.

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.

Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL; International Multiple Sclerosis Genetics Consortium, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL.

Hum Mol Genet. 2011 Sep 1;20(17):3517-24. doi: 10.1093/hmg/ddr250. Epub 2011 Jun 8.

12.

Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.

Maharry SE, Walker CJ, Liyanarachchi S, Mehta S, Patel M, Bainazar MA, Huang X, Lankenau MA, Hoag KW, Ranganathan P, Garzon R, Blachly JS, Guttridge DC, Bloomfield CD, de la Chapelle A, Eisfeld AK.

Cancer Discov. 2016 Sep;6(9):1036-51. doi: 10.1158/2159-8290.CD-16-0023. Epub 2016 Jun 27.

13.

Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues.

Brown AA, Viñuela A, Delaneau O, Spector TD, Small KS, Dermitzakis ET.

Nat Genet. 2017 Dec;49(12):1747-1751. doi: 10.1038/ng.3979. Epub 2017 Oct 23.

PMID:
29058714
14.

Quantifying missing heritability at known GWAS loci.

Gusev A, Bhatia G, Zaitlen N, Vilhjalmsson BJ, Diogo D, Stahl EA, Gregersen PK, Worthington J, Klareskog L, Raychaudhuri S, Plenge RM, Pasaniuc B, Price AL.

PLoS Genet. 2013;9(12):e1003993. doi: 10.1371/journal.pgen.1003993. Epub 2013 Dec 26.

15.

Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis.

Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BM, Mashychev A, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Zipp F, Bertram L.

Neurogenetics. 2014 May;15(2):129-34. doi: 10.1007/s10048-014-0396-y. Epub 2014 Mar 18.

PMID:
24638856
16.
17.

Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes.

Cortes A, Field J, Glazov EA, Hadler J; ANZgene Consortium, Stankovich J, Brown MA.

Hum Mol Genet. 2013 Jun 1;22(11):2283-92. doi: 10.1093/hmg/ddt062. Epub 2013 Feb 12.

PMID:
23406874
18.

Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease.

Meddens CA, Harakalova M, van den Dungen NA, Foroughi Asl H, Hijma HJ, Cuppen EP, Björkegren JL, Asselbergs FW, Nieuwenhuis EE, Mokry M.

Genome Biol. 2016 Nov 30;17(1):247.

19.

Enhancer variants associated with Alzheimer's disease affect gene expression via chromatin looping.

Kikuchi M, Hara N, Hasegawa M, Miyashita A, Kuwano R, Ikeuchi T, Nakaya A.

BMC Med Genomics. 2019 Sep 9;12(1):128. doi: 10.1186/s12920-019-0574-8.

20.

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.

Martin P, McGovern A, Orozco G, Duffus K, Yarwood A, Schoenfelder S, Cooper NJ, Barton A, Wallace C, Fraser P, Worthington J, Eyre S.

Nat Commun. 2015 Nov 30;6:10069. doi: 10.1038/ncomms10069.

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