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27836120,27810625,26852850,23025452,24929253,17894536,29054499,32663586,16551211,29499614,30445230,25944585,34129919,32451773,25388926,24296048,30458054,27552906,29878859,32836137,27082824,29297393,18412536,34808267,30553814,26976481,31676991,21721851,28683222,25192072,26447531,18800879,27993478,25043636,31464559,32862295,35351571,16181001,22290350,33812969,9752023,27639621,28170282,16052546,28075194,30556777,24793155,14602173,29778822,25393346,27448179,15684732,12487221,30316002,24818765,25930239,31517283,36938947,31815554,16796541,28463041,26220014,21133801,26372467,28549971,24074143,23406936,26780380,28510480,26372465,26372466,15737247,12751281,31264190,22691109,28367654,32758026,28612675,34998921,10464864,33860378,31713883,31418632,22543053,28603412,12115821,27964902,23707466,24008503,29886099,9757487,26824873,19174757,35147870,16428920,27449745,30077761,32995953,19075871,30690674,33556627,7724494,21640772,15625816,27161214,31768010,23289401,12270249,29621625,27748638,25876911,34989629,36824288,33161040,19451700,35547784,35643378,30463458,17719763,25151851,29733972,17484142,30731259,26516724,28708440,30033395,23569375,17904774,12737686,25931324,30312722,23421897,30132207,27401410,36253630,24395403,27426972,31147791,30720857,36241775,31139939,27534768,28718049,28890203,35441324,30336185,22973562,28954217,32828976,35358643,33575958,34418472,24921434,30946963,31129343,30783904,21502037,28864391,26290193,19418954,28917963,34077545,28840529,34462876,23286828,35351584,28941830,32980431,25244365,12723679,24508552,30734133,16049900,28389274,34171427,28735415,30179703,33188247,32800937,24563174,34508843,23292025,33200330,31792683,12240938,37005236,29532682,36179925,27623625,21152983,35166601,22820981,23605507,31969100,26609733,10422756,29792988,29160160,30888242,34041715,24871551,30939795,26290194,32217283,33716317,12454794,36678786,34875355,30862480,23608613,35745624,36948474,30673901,27834151,29395490,22816126,35262408,29261454,29148851,3893925,27012934,32623017,35131350,30388902,26876523,28830783,36990172,24299500,28942008,35608335,27337643,28925894,32741913,31613682,29627404,36400254,29490421,36071350,30360739,10623338,10157895,29125912,31678391,29881683,27212477,34774996,32758048,30796625,36739908,35843365,31004652,27774309,31629037,35868587,35948158,34560207,17048511,25682537,19236209,35908637,32827062,2038731,36511428,33535512,28842353,27173989,34171430,26806688,32593641,35984322,30017819,36162608,32104382,14643539,20355503,30951858,32968848,11291200,32151016,36191861,31774357,30141117,25030114,29079338,23949304,32443715,9833999,27547842,12661699,35370200,15757496,34435873,22915941,35335876,33689824,33877899,30759039,24307605,30767769,32805379,31787659,31987851,33045904,32060670,29883795,28821437,28916396,31648015,36863544,33987294,28673875,28903066,21679101,28874611,27703365,29991452,22686623,28743094,26290198,25496601,6435107,29886096,36058349,29561767,34207690,31751812,36283644,26067581,31260784,32593974,12084498,28807905,11839456,29793407,6440305,26831643,33632051,22274758,36103743,28536654,28826144,32512029,11957743,18444012,28854390,36826406,34494246,35026316,24093806,25103332,32072962,22723022,32215754,10160062,32361031,31007093,31513445,8308694,22826884,15189935,26708720,28450166,35659856,35985443,17178200,8321856,33282850,9106394,33410725,29219321,30217767,27547034,35834639,24021087,16086596,31978589,30276666,10794922,25277464,34699949,35779497,37016029,32678723,18800256,35761163,35202727,27860424,36145670,32449087,31012388,11719708,26453787,8818308,32532040,20156730,1001293,34998086,21330617,14710439,10160061,28536796,27536432,26818872,33957225,10623339,18518792,8971424,28584899,29655797,24902629,33540036,16774865,35248734,28684363,36396028,30755779,33220592,24570763,34463937,26726781,9007645,28768120,19235608,29022837,7713202,33769805,9306067,8256235,20454837,14526942,10189572,30618352,31784683,29468423,34516926,25659645,12520080,7292382,12476357,32809156,32071044,32598200,31455817,16774869,36559084,32716667,22393908,36087437,10147078,32017637,18821102,33545572,22336894,34391857,34492805,23722698,23971966,31630028,32668011,32798812,36901592,32782272,16774866,12122571,32050584,24111322,32512146,28260934,26317666,22826885,35171044,24570764,35112802,32739389,16532622,36332164,34374565,34324962,35653381,12693798,26362143,32790531,11311707,33375181,35965841,33870835,30506148,24811243,30296863,12270254,34259174,33325789,11295864,35364181,25516850,31935991,25211475,21948458,34581994,28281196,27471671,31784627,34736753,10834155,27232442,25415404,16774867,29191716,10746950,20032848,32673767,30372894,18686086,34438888,2075640,28880765,14616418,17163249,36651510,23801087,32663488,26446462,9408732,17497529,33989748,36740318,22691110,23516175,12611269,34950976,32904428,32971228,34152197,26290203,31323852,29058607,12751635,36038083,30544055,8583349,32959135,34959469,34971755,29973963,19139288,28447980,26829187,29731372,30956537,6118406,32763274,1628567,33021414,29224407,7307633,29859667,36559160,797567,34880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1,071 results

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Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part II: Dry powder inhaler application.

Kolanjiyil AV, Kleinstreuer C, Sadikot RT. Kolanjiyil AV, et al. Comput Biol Med. 2017 May 1;84:247-253. doi: 10.1016/j.compbiomed.2016.10.025. Epub 2016 Nov 3. Comput Biol Med. 2017. PMID: 27836120

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation.

Kolanjiyil AV, Kleinstreuer C. Kolanjiyil AV, et al. Comput Biol Med. 2016 Dec 1;79:193-204. doi: 10.1016/j.compbiomed.2016.10.020. Epub 2016 Oct 27. Comput Biol Med. 2016. PMID: 27810625

Current Inhalers Deliver Very Small Doses to the Lower Tracheobronchial Airways: Assessment of Healthy and Constricted Lungs.

Walenga RL, Longest PW. Walenga RL, et al. J Pharm Sci. 2016 Jan;105(1):147-59. doi: 10.1016/j.xphs.2015.11.027. Epub 2016 Jan 13. J Pharm Sci. 2016. PMID: 26852850 Free PMC article.

In vitro tests for aerosol deposition. III: effect of inhaler insertion angle on aerosol deposition.

Delvadia RR, Longest PW, Hindle M, Byron PR. Delvadia RR, et al. J Aerosol Med Pulm Drug Deliv. 2013 Jun;26(3):145-56. doi: 10.1089/jamp.2012.0989. Epub 2012 Oct 1. J Aerosol Med Pulm Drug Deliv. 2013. PMID: 23025452

The clinical relevance of dry powder inhaler performance for drug delivery.

Demoly P, Hagedoorn P, de Boer AH, Frijlink HW. Demoly P, et al. Respir Med. 2014 Aug;108(8):1195-203. doi: 10.1016/j.rmed.2014.05.009. Epub 2014 May 24. Respir Med. 2014. PMID: 24929253 Free article.

Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology.

Kleinstreuer C, Shi H, Zhang Z. Kleinstreuer C, et al. J Aerosol Med. 2007 Fall;20(3):294-309. doi: 10.1089/jam.2006.0617. J Aerosol Med. 2007. PMID: 17894536

Coupled in silico platform: Computational fluid dynamics (CFD) and physiologically-based pharmacokinetic (PBPK) modelling.

Vulović A, Šušteršič T, Cvijić S, Ibrić S, Filipović N. Vulović A, et al. Eur J Pharm Sci. 2018 Feb 15;113:171-184. doi: 10.1016/j.ejps.2017.10.022. Epub 2017 Oct 17. Eur J Pharm Sci. 2018. PMID: 29054499

Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data.

Ahookhosh K, Saidi M, Aminfar H, Mohammadpourfard M, Hamishehkar H, Yaqoubi S. Ahookhosh K, et al. Int J Pharm. 2020 Sep 25;587:119599. doi: 10.1016/j.ijpharm.2020.119599. Epub 2020 Jul 11. Int J Pharm. 2020. PMID: 32663586

Dry powder aerosol delivery systems: current and future research directions.

Chan HK. Chan HK. J Aerosol Med. 2006 Spring;19(1):21-7. doi: 10.1089/jam.2006.19.21. J Aerosol Med. 2006. PMID: 16551211 Review.

Use of functional respiratory imaging to characterize the effect of inhalation profile and particle size on lung deposition of inhaled corticosteroid/long-acting β2-agonists delivered via a pressurized metered-dose inhaler.

Van Holsbeke C, De Backer J, Vos W, Marshall J. Van Holsbeke C, et al. Ther Adv Respir Dis. 2018 Jan-Dec;12:1753466618760948. doi: 10.1177/1753466618760948. Ther Adv Respir Dis. 2018. PMID: 29499614 Free PMC article.

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