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Items: 1 to 20 of 94

1.

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.

Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, Jostins L, Barber T, Kaur G, Kuttikkatte SB, Leach OA, Desel C, Faergeman SL, Cheeseman J, Neville MJ, Sawcer S, Compston A, Johnson AR, Everett C, Bell JI, Karpe F, Ultsch M, Eigenbrot C, McVean G, Fugger L.

Sci Transl Med. 2016 Nov 2;8(363):363ra149.

2.

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Rönnblom L, Michel F, Pellegrini S.

J Immunol. 2013 Mar 1;190(5):2335-44. doi: 10.4049/jimmunol.1203118. Epub 2013 Jan 28.

3.

Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.

Lee YH, Bae SC.

Lupus. 2016 Oct;25(12):1307-14. doi: 10.1177/0961203316638933. Epub 2016 Mar 14.

PMID:
26980740
4.

Therapeutic potential of tyrosine kinase 2 in autoimmunity.

Liang Y, Zhu Y, Xia Y, Peng H, Yang XK, Liu YY, Xu WD, Pan HF, Ye DQ.

Expert Opin Ther Targets. 2014 May;18(5):571-80. doi: 10.1517/14728222.2014.892925. Epub 2014 Mar 21. Review.

PMID:
24654603
5.

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

Diogo D, Bastarache L, Liao KP, Graham RR, Fulton RS, Greenberg JD, Eyre S, Bowes J, Cui J, Lee A, Pappas DA, Kremer JM, Barton A, Coenen MJ, Franke B, Kiemeney LA, Mariette X, Richard-Miceli C, Canhão H, Fonseca JE, de Vries N, Tak PP, Crusius JB, Nurmohamed MT, Kurreeman F, Mikuls TR, Okada Y, Stahl EA, Larson DE, Deluca TL, O'Laughlin M, Fronick CC, Fulton LL, Kosoy R, Ransom M, Bhangale TR, Ortmann W, Cagan A, Gainer V, Karlson EW, Kohane I, Murphy SN, Martin J, Zhernakova A, Klareskog L, Padyukov L, Worthington J, Mardis ER, Seldin MF, Gregersen PK, Behrens T, Raychaudhuri S, Denny JC, Plenge RM.

PLoS One. 2015 Apr 7;10(4):e0122271. doi: 10.1371/journal.pone.0122271. eCollection 2015.

6.

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility.

Couturier N, Bucciarelli F, Nurtdinov RN, Debouverie M, Lebrun-Frenay C, Defer G, Moreau T, Confavreux C, Vukusic S, Cournu-Rebeix I, Goertsches RH, Zettl UK, Comabella M, Montalban X, Rieckmann P, Weber F, Müller-Myhsok B, Edan G, Fontaine B, Mars LT, Saoudi A, Oksenberg JR, Clanet M, Liblau RS, Brassat D.

Brain. 2011 Mar;134(Pt 3):693-703. doi: 10.1093/brain/awr010.

PMID:
21354972
7.

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

López-Isac E, Campillo-Davo D, Bossini-Castillo L, Guerra SG, Assassi S, Simeón CP, Carreira P, Ortego-Centeno N, García de la Peña P; Spanish Scleroderma Group, Beretta L, Santaniello A, Bellocchi C, Lunardi C, Moroncini G, Gabrielli A, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, de Vries-Bouwstra J, Herrick A, Worthington J, Denton CP, Fonseca C, Radstake TR, Mayes MD, Martín J.

Ann Rheum Dis. 2016 Aug;75(8):1521-6. doi: 10.1136/annrheumdis-2015-208154. Epub 2015 Sep 2.

8.

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity.

Strobl B, Stoiber D, Sexl V, Mueller M.

Front Biosci (Landmark Ed). 2011 Jun 1;16:3214-32. Review.

PMID:
21622231
9.

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).

Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z.

J Biol Chem. 2015 Nov 6;290(45):27261-70. doi: 10.1074/jbc.M115.672048. Epub 2015 Sep 10.

10.

Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases.

Tao JH, Zou YF, Feng XL, Li J, Wang F, Pan FM, Ye DQ.

Mol Biol Rep. 2011 Oct;38(7):4663-72. doi: 10.1007/s11033-010-0601-5. Epub 2010 Dec 8.

PMID:
21140222
11.

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.

Shaw MH, Boyartchuk V, Wong S, Karaghiosoff M, Ragimbeau J, Pellegrini S, Muller M, Dietrich WF, Yap GS.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11594-9. Epub 2003 Sep 18.

12.

Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.

Jani M, Massey J, Wedderburn LR, Vencovský J, Danko K, Lundberg IE, Padyukov L, Selva-O'Callaghan A, Radstake T, Platt H, Warren RB, Griffiths CE, Lee A, Gregersen PK, Miller FW, Ollier WE, Cooper RG, Chinoy H, Lamb JA; EUMYONET.

Ann Rheum Dis. 2014 Sep;73(9):1750-2. doi: 10.1136/annrheumdis-2014-205440. Epub 2014 May 7. No abstract available.

13.

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.

Oyamada A, Ikebe H, Itsumi M, Saiwai H, Okada S, Shimoda K, Iwakura Y, Nakayama KI, Iwamoto Y, Yoshikai Y, Yamada H.

J Immunol. 2009 Dec 1;183(11):7539-46. doi: 10.4049/jimmunol.0902740. Epub 2009 Nov 16.

14.

Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.

Gutierrez-Arcelus M, Rich SS, Raychaudhuri S.

Nat Rev Genet. 2016 Mar;17(3):160-74. doi: 10.1038/nrg.2015.33. Epub 2016 Feb 15. Review.

15.

Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy.

Leon Rodriguez DA, Acosta-Herrera M, Carmona FD, Dolade N, Vargas S, Echeverría LE, González CI, Martin J.

PLoS One. 2018 Jan 5;13(1):e0190591. doi: 10.1371/journal.pone.0190591. eCollection 2018.

16.

A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.

Spach KM, Noubade R, McElvany B, Hickey WF, Blankenhorn EP, Teuscher C.

J Immunol. 2009 Jun 15;182(12):7776-83. doi: 10.4049/jimmunol.0900142.

17.

Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families.

Cunninghame Graham DS, Akil M, Vyse TJ.

Rheumatology (Oxford). 2007 Jun;46(6):927-30. Epub 2007 Mar 23.

PMID:
17384181
18.

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.

Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT.

Cancer Discov. 2013 May;3(5):564-77. doi: 10.1158/2159-8290.CD-12-0504. Epub 2013 Mar 7.

19.

Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.

Bieber AJ, Suwansrinon K, Kerkvliet J, Zhang W, Pease LR, Rodriguez M.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):792-7. doi: 10.1073/pnas.0906589107. Epub 2009 Dec 22.

20.

TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

Peluso C, Christofolini DM, Goldman CS, Mafra FA, Cavalcanti V, Barbosa CP, Bianco B.

Hum Immunol. 2013 Jan;74(1):93-7. doi: 10.1016/j.humimm.2012.09.007. Epub 2012 Sep 20.

PMID:
23000200

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