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Items: 1 to 20 of 379

1.

Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy.

Nalbandian A, Khan AA, Srivastava R, Llewellyn KJ, Tan B, Shukr N, Fazli Y, Kimonis VE, BenMohamed L.

Inflammation. 2017 Feb;40(1):21-41. doi: 10.1007/s10753-016-0449-5.

2.

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC.

J Hepatol. 2017 May;66(5):1037-1046. doi: 10.1016/j.jhep.2017.01.022. Epub 2017 Feb 3.

PMID:
28167322
3.

NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report.

van der Heijden T, Kritikou E, Venema W, van Duijn J, van Santbrink PJ, Slütter B, Foks AC, Bot I, Kuiper J.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1457-1461. doi: 10.1161/ATVBAHA.117.309575. Epub 2017 Jun 8.

PMID:
28596375
4.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA.

Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16.

5.

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.

Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP.

J Immunol. 2016 Sep 15;197(6):2421-33. doi: 10.4049/jimmunol.1600035. Epub 2016 Aug 12.

6.

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA.

Brain Behav Immun. 2017 Mar;61:306-316. doi: 10.1016/j.bbi.2016.12.014. Epub 2016 Dec 18.

PMID:
28003153
7.

Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms.

Dolunay A, Senol SP, Temiz-Resitoglu M, Guden DS, Sari AN, Sahan-Firat S, Tunctan B.

Inflammation. 2017 Apr;40(2):366-386. doi: 10.1007/s10753-016-0483-3.

PMID:
27924425
8.

Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages.

Yeon SH, Yang G, Lee HE, Lee JY.

J Leukoc Biol. 2017 Jan;101(1):205-215. doi: 10.1189/jlb.3VMA1215-579RR. Epub 2016 Jun 2.

PMID:
27256568
9.

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome.

Shao A, Wu H, Hong Y, Tu S, Sun X, Wu Q, Zhao Q, Zhang J, Sheng J.

Mol Neurobiol. 2016 Jul;53(5):3462-3476. doi: 10.1007/s12035-015-9242-y. Epub 2015 Jun 20.

PMID:
26091790
10.

The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation.

Gan W, Ren J, Li T, Lv S, Li C, Liu Z, Yang M.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):1-10. doi: 10.1016/j.bbadis.2017.10.001. Epub 2017 Oct 3.

PMID:
28986310
11.

Activation of the NLRP3 inflammasome in microglia: the role of ceramide.

Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT.

J Neurochem. 2017 Dec;143(5):534-550. doi: 10.1111/jnc.14225. Epub 2017 Oct 26.

PMID:
28940479
12.

Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes.

Haggadone MD, Grailer JJ, Fattahi F, Zetoune FS, Ward PA.

Mediators Inflamm. 2016;2016:1340156. doi: 10.1155/2016/1340156. Epub 2016 Jun 7.

13.

Autophagy Inhibition Contributes to ROS-Producing NLRP3-Dependent Inflammasome Activation and Cytokine Secretion in High Glucose-Induced Macrophages.

Dai J, Zhang X, Li L, Chen H, Chai Y.

Cell Physiol Biochem. 2017;43(1):247-256. doi: 10.1159/000480367. Epub 2017 Aug 30.

14.

Role of the NLRP3 inflammasome in a model of acute burn-induced pain.

Deuis JR, Yin K, Cooper MA, Schroder K, Vetter I.

Burns. 2017 Mar;43(2):304-309. doi: 10.1016/j.burns.2016.09.001. Epub 2016 Dec 28.

PMID:
28040362
15.

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice.

Wang R, Wang Y, Mu N, Lou X, Li W, Chen Y, Fan D, Tan H.

Lab Invest. 2017 Aug;97(8):922-934. doi: 10.1038/labinvest.2017.30. Epub 2017 Apr 10.

16.

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.

PMID:
28252317
17.
18.

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.

Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S.

Mol Immunol. 2013 Dec;56(4):471-9. doi: 10.1016/j.molimm.2013.05.005. Epub 2013 Aug 1.

PMID:
23911403
19.

Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production.

Hua KF, Chou JC, Ka SM, Tasi YL, Chen A, Wu SH, Chiu HW, Wong WT, Wang YF, Tsai CL, Ho CL, Lin CH.

J Cell Physiol. 2015 Apr;230(4):863-74. doi: 10.1002/jcp.24815.

PMID:
25294243
20.

The mechanism of NLRP3 inflammasome initiation: Trimerization but not dimerization of the NLRP3 pyrin domain induces robust activation of IL-1β.

Sušjan P, Roškar S, Hafner-Bratkovič I.

Biochem Biophys Res Commun. 2017 Feb 5;483(2):823-828. doi: 10.1016/j.bbrc.2017.01.008. Epub 2017 Jan 5.

PMID:
28065854

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