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p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.

Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J.

Cancer Cell. 2016 Oct 10;30(4):595-609. doi: 10.1016/j.ccell.2016.09.004.


p62 functions as an oncogene in colorectal cancer through inhibiting apoptosis and promoting cell proliferation by interacting with the vitamin D receptor.

Zhang J, Yang S, Xu B, Wang T, Zheng Y, Liu F, Ren F, Jiang J, Shi H, Zou B, Lu X, Lu S, Dong L.

Cell Prolif. 2019 May;52(3):e12585. doi: 10.1111/cpr.12585. Epub 2019 Feb 22.


CCN1/Cyr61 enhances the function of hepatic stellate cells in promoting the progression of hepatocellular carcinoma.

Li ZQ, Wu WR, Zhao C, Zhao C, Zhang XL, Yang Z, Pan J, Si WK.

Int J Mol Med. 2018 Mar;41(3):1518-1528. doi: 10.3892/ijmm.2017.3356. Epub 2017 Dec 29.


Activation of Hepatic Stellate Cells During Liver Carcinogenesis Requires Fibrinogen/Integrin αvβ5 in Zebrafish.

Yan C, Yang Q, Gong Z.

Neoplasia. 2018 May;20(5):533-542. doi: 10.1016/j.neo.2018.02.002. Epub 2018 Apr 9.


Liganded Vitamin D Receptor Through Its Interacting Repressor Inhibits the Expression of Type I Collagen α1.

Wan LY, Zhang YQ, Li JM, Tang HQ, Chen MD, Ni YR, Huang H, Liu CB, Wu JF.

DNA Cell Biol. 2016 Sep;35(9):498-505. doi: 10.1089/dna.2016.3367. Epub 2016 Jun 28.


Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma.

Wright JH, Johnson MM, Shimizu-Albergine M, Bauer RL, Hayes BJ, Surapisitchat J, Hudkins KL, Riehle KJ, Johnson SC, Yeh MM, Bammler TK, Beyer RP, Gilbertson DG, Alpers CE, Fausto N, Campbell JS.

Int J Cancer. 2014 Feb 15;134(4):778-88. doi: 10.1002/ijc.28421. Epub 2013 Sep 16.


Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein.

O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW.

Hepatology. 2015 Aug;62(2):615-26. doi: 10.1002/hep.27645. Epub 2015 Mar 23.


A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response.

Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM.

Cell. 2013 Apr 25;153(3):601-13. doi: 10.1016/j.cell.2013.03.028.


Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.

Nguyen G, Park SY, Le CT, Park WS, Choi DH, Cho EH.

Biochem Biophys Res Commun. 2018 Jan 22;495(4):2649-2656. doi: 10.1016/j.bbrc.2017.12.143. Epub 2017 Dec 24.


Hepatic stellate cells in inflammation-fibrosis-carcinoma axis.

Wang BB, Cheng JY, Gao HH, Zhang Y, Chen ZN, Bian H.

Anat Rec (Hoboken). 2010 Sep;293(9):1492-6. doi: 10.1002/ar.21173.


A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.

Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T.

Gastroenterology. 2012 Jan;142(1):152-164.e10. doi: 10.1053/j.gastro.2011.09.049. Epub 2011 Oct 10.


Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation.

Twu YC, Lee TS, Lin YL, Hsu SM, Wang YH, Liao CY, Wang CK, Liang YC, Liao YJ.

Int J Mol Sci. 2016 Jul 13;17(7). pii: E1122. doi: 10.3390/ijms17071122.


Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.

Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Usui S, Furuhashi H, Kimura A, Nishiyama K, Maejima T, Okada Y, Kurihara C, Shimamura K, Ebinuma H, Saito H, Yokoyama H, Watanabe C, Komoto S, Nagao S, Sugiyama K, Aosasa S, Hatsuse K, Yamamoto J, Hibi T, Miura S, Hokari R, Kanai T.

J Hepatol. 2014 Jul;61(1):98-106. doi: 10.1016/j.jhep.2014.03.018. Epub 2014 Mar 18.


Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats.

Abramovitch S, Dahan-Bachar L, Sharvit E, Weisman Y, Ben Tov A, Brazowski E, Reif S.

Gut. 2011 Dec;60(12):1728-37. doi: 10.1136/gut.2010.234666. Epub 2011 Aug 4.


IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation.

Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, Wang X, Ryffel B, Sun B.

J Immunol. 2013 Aug 15;191(4):1835-44. doi: 10.4049/jimmunol.1203013. Epub 2013 Jul 10.


Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever.

Carloni V, Luong TV, Rombouts K.

Liver Int. 2014 Jul;34(6):834-43. doi: 10.1111/liv.12465. Epub 2014 Feb 12. Review.


Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.

Lan T, Kisseleva T, Brenner DA.

PLoS One. 2015 Jul 29;10(7):e0129743. doi: 10.1371/journal.pone.0129743. eCollection 2015.


Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells.

Lo Re O, Panebianco C, Porto S, Cervi C, Rappa F, Di Biase S, Caraglia M, Pazienza V, Vinciguerra M.

J Cell Physiol. 2018 Feb;233(2):1202-1212. doi: 10.1002/jcp.25987. Epub 2017 Jul 11.


Succinate induces hepatic fibrogenesis by promoting activation, proliferation, and migration, and inhibiting apoptosis of hepatic stellate cells.

Park SY, Le CT, Sung KY, Choi DH, Cho EH.

Biochem Biophys Res Commun. 2018 Feb 5;496(2):673-678. doi: 10.1016/j.bbrc.2018.01.106. Epub 2018 Jan 20.


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