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Items: 1 to 20 of 227

1.

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.

Dagklis A, Demeyer S, De Bie J, Radaelli E, Pauwels D, Degryse S, Gielen O, Vicente C, Vandepoel R, Geerdens E, Uyttebroeck A, Boeckx N, de Bock CE, Cools J.

Blood. 2016 Dec 8;128(23):2642-2654. Epub 2016 Sep 30.

PMID:
27694322
2.

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R.

Oncotarget. 2016 Feb 23;7(8):9250-70. doi: 10.18632/oncotarget.7062.

3.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

4.

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.

Gruber W, Hutzinger M, Elmer DP, Parigger T, Sternberg C, Cegielkowski L, Zaja M, Leban J, Michel S, Hamm S, Vitt D, Aberger F.

Oncotarget. 2016 Feb 9;7(6):7134-48. doi: 10.18632/oncotarget.6910.

5.

Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway.

Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL, Majumder S.

Cancer Res. 2012 Oct 1;72(19):5048-59. doi: 10.1158/0008-5472.CAN-12-1248. Epub 2012 Aug 8.

6.

Targeting the hedgehog-glioma-associated oncogene homolog pathway inhibits bleomycin-induced lung fibrosis in mice.

Moshai EF, Wémeau-Stervinou L, Cigna N, Brayer S, Sommé JM, Crestani B, Mailleux AA.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):11-25. doi: 10.1165/rcmb.2013-0154OC.

PMID:
24450438
7.

Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death.

Wang X, Wei S, Zhao Y, Shi C, Liu P, Zhang C, Lei Y, Zhang B, Bai B, Huang Y, Zhang H.

Cancer Lett. 2017 Jan 28;385:128-136. doi: 10.1016/j.canlet.2016.10.034. Epub 2016 Oct 31.

PMID:
27810405
8.

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer.

Riaz SK, Khan JS, Shah STA, Wang F, Ye L, Jiang WG, Malik MFA.

Cell Commun Signal. 2018 Jan 8;16(1):3. doi: 10.1186/s12964-017-0213-y.

9.

The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met.

Williamson AJ, Doscas ME, Ye J, Heiden KB, Xing M, Li Y, Prinz RA, Xu X.

Oncotarget. 2016 Mar 1;7(9):10472-85. doi: 10.18632/oncotarget.7228.

10.

Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.

Arnhold V, Boos J, Lanvers-Kaminsky C.

Cancer Chemother Pharmacol. 2016 Mar;77(3):495-505. doi: 10.1007/s00280-016-2962-5. Epub 2016 Jan 19.

PMID:
26781311
11.

GANT-61 and GDC-0449 induce apoptosis of prostate cancer stem cells through a GLI-dependent mechanism.

Tong W, Qiu L, Qi M, Liu J, Hu K, Lin W, Huang Y, Fu J.

J Cell Biochem. 2018 Apr;119(4):3641-3652. doi: 10.1002/jcb.26572. Epub 2018 Jan 5.

PMID:
29231999
12.

Smoothened is a poor prognosis factor and a potential therapeutic target in glioma.

Tu Y, Niu M, Xie P, Yue C, Liu N, Qi Z, Gao S, Liu H, Shi Q, Yu R, Liu X.

Sci Rep. 2017 Feb 14;7:42630. doi: 10.1038/srep42630.

13.

Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.

Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM, Santucci A.

J Cell Physiol. 2017 Nov;232(11):3103-3111. doi: 10.1002/jcp.25761. Epub 2017 Mar 29.

PMID:
28019670
14.

Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance.

Shahi MH, Farheen S, Mariyath MP, Castresana JS.

Tumour Biol. 2016 Nov;37(11):15107-15114. Epub 2016 Sep 23.

PMID:
27662839
15.

Role of Hedgehog-Gli1 signaling in the enhanced proliferation and differentiation of MG63 cells enabled by hierarchical micro-/nanotextured topography.

Lin Y, Huang Y, He J, Chen F, He Y, Zhang W.

Int J Nanomedicine. 2017 Apr 20;12:3267-3280. doi: 10.2147/IJN.S135045. eCollection 2017.

16.

Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects.

Wellbrock J, Latuske E, Köhler J, Wagner K, Stamm H, Vettorazzi E, Vohwinkel G, Klokow M, Uibeleisen R, Ehm P, Riecken K, Loges S, Thol F, Schubert C, Amling M, Jücker M, Bokemeyer C, Heuser M, Krauter J, Fiedler W.

Clin Cancer Res. 2015 May 15;21(10):2388-98. doi: 10.1158/1078-0432.CCR-14-1059. Epub 2015 Mar 5.

17.

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.

Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg OM, Larsson R, Kogner P, Zaphiropoulos PG, Johnsen JI.

Int J Cancer. 2013 Apr 1;132(7):1516-24. doi: 10.1002/ijc.27820. Epub 2012 Oct 3.

18.

Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells.

Ghezali L, Liagre B, Limami Y, Beneytout JL, Leger DY.

PLoS One. 2014 Apr 16;9(4):e95016. doi: 10.1371/journal.pone.0095016. eCollection 2014.

19.

Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma.

Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Chang CF, Hsiau HI, Hung ZH, Yu MC, Chang FY.

Am J Surg. 2015 Sep;210(3):554-60. doi: 10.1016/j.amjsurg.2015.03.001. Epub 2015 May 8.

PMID:
26073903
20.

Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.

J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007. Epub 2013 Sep 21.

PMID:
24063979

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