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Items: 1 to 20 of 123

1.

B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.

Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6182-E6191. Epub 2016 Sep 26.

2.

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.

Ortler S, Leder C, Mittelbronn M, Zozulya AL, Knolle PA, Chen L, Kroner A, Wiendl H.

Eur J Immunol. 2008 Jun;38(6):1734-44. doi: 10.1002/eji.200738071.

3.

Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.

Magnus T, Schreiner B, Korn T, Jack C, Guo H, Antel J, Ifergan I, Chen L, Bischof F, Bar-Or A, Wiendl H.

J Neurosci. 2005 Mar 9;25(10):2537-46.

4.

B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway.

Herold M, Posevitz V, Chudyka D, Hucke S, Groß C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, Wiendl H.

J Immunol. 2015 Oct 15;195(8):3584-95. doi: 10.4049/jimmunol.1402746. Epub 2015 Sep 16.

5.

PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.

Schreiner B, Bailey SL, Shin T, Chen L, Miller SD.

Eur J Immunol. 2008 Oct;38(10):2706-17. doi: 10.1002/eji.200838137.

6.

Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity.

Fabis MJ, Phares TW, Kean RB, Koprowski H, Hooper DC.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15511-6. doi: 10.1073/pnas.0807656105. Epub 2008 Sep 30.

7.

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.

Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K.

Nat Commun. 2015 Sep 10;6:8164. doi: 10.1038/ncomms9164.

8.

Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis.

Lanz TV, Becker S, Osswald M, Bittner S, Schuhmann MK, Opitz CA, Gaikwad S, Wiestler B, Litzenburger UM, Sahm F, Ott M, Iwantscheff S, Grabitz C, Mittelbronn M, von Deimling A, Winkler F, Meuth SG, Wick W, Platten M.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14735-40. doi: 10.1073/pnas.1302569110. Epub 2013 Aug 19.

9.

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.

Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG.

Nat Med. 2013 Sep;19(9):1161-5. doi: 10.1038/nm.3303. Epub 2013 Aug 11.

PMID:
23933981
10.

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.

Göbel K, Pankratz S, Schneider-Hohendorf T, Bittner S, Schuhmann MK, Langer HF, Stoll G, Wiendl H, Kleinschnitz C, Meuth SG.

J Autoimmun. 2011 Mar;36(2):106-14. doi: 10.1016/j.jaut.2010.11.004. Epub 2011 Jan 8.

PMID:
21216565
11.

Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain.

Becher B, Bechmann I, Greter M.

J Mol Med (Berl). 2006 Jul;84(7):532-43. Epub 2006 Jun 14. Review.

PMID:
16773356
12.

CD44 deficiency contributes to enhanced experimental autoimmune encephalomyelitis: a role in immune cells and vascular cells of the blood-brain barrier.

Flynn KM, Michaud M, Madri JA.

Am J Pathol. 2013 Apr;182(4):1322-36. doi: 10.1016/j.ajpath.2013.01.003. Epub 2013 Feb 12.

13.

Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis.

Lengfeld JE, Lutz SE, Smith JR, Diaconu C, Scott C, Kofman SB, Choi C, Walsh CM, Raine CS, Agalliu I, Agalliu D.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1168-E1177. doi: 10.1073/pnas.1609905114. Epub 2017 Jan 30.

14.

Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation.

Krishnamoorthy G, Lassmann H, Wekerle H, Holz A.

J Clin Invest. 2006 Sep;116(9):2385-92.

15.

Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models.

Fabis MJ, Scott GS, Kean RB, Koprowski H, Hooper DC.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5656-61. Epub 2007 Mar 19.

16.

Innate IFN-γ ameliorates experimental autoimmune encephalomyelitis and promotes myeloid expansion and PDL-1 expression.

White MPJ, Webster G, Leonard F, La Flamme AC.

Sci Rep. 2018 Jan 10;8(1):259. doi: 10.1038/s41598-017-18543-z.

17.

Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions.

Alvarez JI, Saint-Laurent O, Godschalk A, Terouz S, Briels C, Larouche S, Bourbonnière L, Larochelle C, Prat A.

Neurobiol Dis. 2015 Feb;74:14-24. doi: 10.1016/j.nbd.2014.09.016. Epub 2014 Nov 1.

PMID:
25448765
18.

IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(-/-) mice.

Cohen SJ, Cohen IR, Nussbaum G.

J Immunol. 2010 Jan 1;184(1):212-21. doi: 10.4049/jimmunol.0900296. Epub 2009 Nov 30.

19.

Laquinimod enhances central nervous system barrier functions.

Lühder F, Kebir H, Odoardi F, Litke T, Sonneck M, Alvarez JI, Winchenbach J, Eckert N, Hayardeny L, Sorani E, Lodygin D, Flügel A, Prat A.

Neurobiol Dis. 2017 Jun;102:60-69. doi: 10.1016/j.nbd.2017.02.002. Epub 2017 Feb 22.

PMID:
28235673
20.

Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis.

Phares TW, Stohlman SA, Hinton DR, Atkinson R, Bergmann CC.

J Immunol. 2010 Nov 1;185(9):5607-18. doi: 10.4049/jimmunol.1001984. Epub 2010 Sep 27.

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