Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 99

1.

PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19. Erratum in: Nature. 2017 Feb 2;542(7639):124.

2.

PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.

Foubert P, Kaneda MM, Varner JA.

Cancer Immunol Res. 2017 Nov;5(11):957-968. doi: 10.1158/2326-6066.CIR-17-0143. Epub 2017 Sep 28.

3.

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.

Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA.

Cancer Discov. 2016 Aug;6(8):870-85. doi: 10.1158/2159-8290.CD-15-1346. Epub 2016 May 13.

4.

Anti-inflammation effects of naloxone involve phosphoinositide 3-kinase delta and gamma.

Wang TY, Su NY, Shih PC, Tsai PS, Huang CJ.

J Surg Res. 2014 Dec;192(2):599-606. doi: 10.1016/j.jss.2014.06.022. Epub 2014 Jun 14.

PMID:
25016442
5.

Akt, mTOR and NF-κB pathway activation in Treponema pallidum stimulates M1 macrophages.

Lin LR, Gao ZX, Lin Y, Zhu XZ, Liu W, Liu D, Gao K, Tong ML, Zhang HL, Liu LL, Xiao Y, Niu JJ, Liu F, Yang TC.

Int Immunopharmacol. 2018 Jun;59:181-186. doi: 10.1016/j.intimp.2018.03.040. Epub 2018 Apr 12.

PMID:
29656208
6.

Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway.

Cunha TM, Souza GR, Domingues AC, Carreira EU, Lotufo CM, Funez MI, Verri WA Jr, Cunha FQ, Ferreira SH.

Mol Pain. 2012 Feb 8;8:10. doi: 10.1186/1744-8069-8-10.

7.

p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.

Turvey ME, Klingler-Hoffmann M, Hoffmann P, McColl SR.

Immunol Cell Biol. 2015 Sep;93(8):735-43. doi: 10.1038/icb.2015.35. Epub 2015 Mar 10.

PMID:
25753393
8.

PI3Kγ kinase activity is required for optimal T-cell activation and differentiation.

Ladygina N, Gottipati S, Ngo K, Castro G, Ma JY, Banie H, Rao TS, Fung-Leung WP.

Eur J Immunol. 2013 Dec;43(12):3183-96. doi: 10.1002/eji.201343812. Epub 2013 Oct 9.

9.

PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R.

Br J Pharmacol. 2014 Jul;171(13):3328-37. doi: 10.1111/bph.12698.

10.

PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells.

Azzi J, Thueson L, Moore R, Abdoli R, Reijonen H, Abdi R.

PLoS One. 2017 Jan 12;12(1):e0169695. doi: 10.1371/journal.pone.0169695. eCollection 2017.

12.

Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt.

Nakajima S, Hiramatsu N, Hayakawa K, Saito Y, Kato H, Huang T, Yao J, Paton AW, Paton JC, Kitamura M.

Mol Cell Biol. 2011 Apr;31(8):1710-8. doi: 10.1128/MCB.00939-10. Epub 2011 Feb 7.

13.

PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses.

Sai J, Owens P, Novitskiy SV, Hawkins OE, Vilgelm AE, Yang J, Sobolik T, Lavender N, Johnson AC, McClain C, Ayers GD, Kelley MC, Sanders M, Mayer IA, Moses HL, Boothby M, Richmond A.

Clin Cancer Res. 2017 Jul 1;23(13):3371-3384. doi: 10.1158/1078-0432.CCR-16-2142. Epub 2016 Dec 21. Erratum in: Clin Cancer Res. 2018 Aug 1;24(15):3782.

14.

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP.

Nature. 2016 Sep 22;537(7621):539-543. doi: 10.1038/nature19364. Epub 2016 Sep 14.

15.

PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice.

Li H, Park D, Abdul-Muneer PM, Xu B, Wang H, Xing B, Wu D, Li S.

Neuroscience. 2013 Dec 3;253:89-99. doi: 10.1016/j.neuroscience.2013.08.051. Epub 2013 Sep 3.

PMID:
24012746
16.

PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.

Breasson L, Sardi C, Becattini B, Zani F, Solinas G.

FASEB J. 2018 Jan;32(1):319-329. doi: 10.1096/fj.201700372RR. Epub 2017 Sep 13.

PMID:
28904022
17.

Regulation of PD-L1: a novel role of pro-survival signalling in cancer.

Chen J, Jiang CC, Jin L, Zhang XD.

Ann Oncol. 2016 Mar;27(3):409-16. doi: 10.1093/annonc/mdv615. Epub 2015 Dec 17. Review.

PMID:
26681673
18.

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM.

Cancer Discov. 2016 Mar;6(3):270-85. doi: 10.1158/2159-8290.CD-15-0827. Epub 2015 Dec 29. Erratum in: Cancer Discov. 2016 Jul;6(7):802.

19.

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.

Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R.

Nat Commun. 2017 Oct 16;8(1):951. doi: 10.1038/s41467-017-00982-x.

20.

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment.

Piddock RE, Loughran N, Marlein CR, Robinson SD, Edwards DR, Yu S, Pillinger GE, Zhou Z, Zaitseva L, Auger MJ, Rushworth SA, Bowles KM.

Blood Cancer J. 2017 Mar 10;7(3):e539. doi: 10.1038/bcj.2017.16.

Supplemental Content

Support Center