Similar articles for PMID: 27618677

Year	Number of Results
1991	1
1996	1
1997	2
1998	1
1999	1
2001	3
2002	3
2003	3
2005	3
2006	4
2007	1
2008	3
2009	5
2010	5
2011	2
2012	3
2013	2
2014	4
2015	6
2016	7
2017	9
2018	11
2019	4
2020	5
2022	2
2023	1
2024	0

1

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.

Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ. Foster DJ, et al. Neuron. 2016 Sep 21;91(6):1244-1252. doi: 10.1016/j.neuron.2016.08.017. Epub 2016 Sep 8. Neuron. 2016. PMID: 27618677 Free PMC article.

2

Muscarinic acetylcholine M₄ receptors play a critical role in oxotremorine-induced DARPP-32 phosphorylation at threonine 75 in isolated medium spiny neurons.

Liu L, Huang Y, Huang Q, Zhao Z, Yu J, Wang L. Liu L, et al. Neuropharmacology. 2017 May 1;117:376-386. doi: 10.1016/j.neuropharm.2017.02.026. Epub 2017 Mar 1. Neuropharmacology. 2017. PMID: 28257887

3

The high efficacy of muscarinic M4 receptor in D1 medium spiny neurons reverses striatal hyperdopaminergia.

Nair AG, Castro LRV, El Khoury M, Gorgievski V, Giros B, Tzavara ET, Hellgren-Kotaleski J, Vincent P. Nair AG, et al. Neuropharmacology. 2019 Mar 1;146:74-83. doi: 10.1016/j.neuropharm.2018.11.029. Epub 2018 Nov 22. Neuropharmacology. 2019. PMID: 30468798

4

Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.

Zhang W, Yamada M, Gomeza J, Basile AS, Wess J. Zhang W, et al. J Neurosci. 2002 Aug 1;22(15):6347-52. doi: 10.1523/JNEUROSCI.22-15-06347.2002. J Neurosci. 2002. PMID: 12151512 Free PMC article.

5

Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.

Leach K, Loiacono RE, Felder CC, McKinzie DL, Mogg A, Shaw DB, Sexton PM, Christopoulos A. Leach K, et al. Neuropsychopharmacology. 2010 Mar;35(4):855-69. doi: 10.1038/npp.2009.194. Epub 2009 Nov 25. Neuropsychopharmacology. 2010. PMID: 19940843 Free PMC article.

6

Activation of the mGlu₁ metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M₄ muscarinic receptor allosteric modulators.

Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ. Yohn SE, et al. Mol Psychiatry. 2020 Nov;25(11):2786-2799. doi: 10.1038/s41380-018-0206-2. Epub 2018 Aug 16. Mol Psychiatry. 2020. PMID: 30116027 Free PMC article.

7

Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.

Croy CH, Schober DA, Xiao H, Quets A, Christopoulos A, Felder CC. Croy CH, et al. Mol Pharmacol. 2014 Jul;86(1):106-15. doi: 10.1124/mol.114.091751. Epub 2014 May 7. Mol Pharmacol. 2014. PMID: 24807965

8

Modulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in mice.

Thomsen M, Wess J, Fulton BS, Fink-Jensen A, Caine SB. Thomsen M, et al. Psychopharmacology (Berl). 2010 Feb;208(3):401-16. doi: 10.1007/s00213-009-1740-z. Epub 2009 Dec 15. Psychopharmacology (Berl). 2010. PMID: 20013114 Free PMC article.

9

Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100.

Byun NE, Grannan M, Bubser M, Barry RL, Thompson A, Rosanelli J, Gowrishankar R, Kelm ND, Damon S, Bridges TM, Melancon BJ, Tarr JC, Brogan JT, Avison MJ, Deutch AY, Wess J, Wood MR, Lindsley CW, Gore JC, Conn PJ, Jones CK. Byun NE, et al. Neuropsychopharmacology. 2014 Jun;39(7):1578-93. doi: 10.1038/npp.2014.2. Epub 2014 Jan 20. Neuropsychopharmacology. 2014. PMID: 24442096 Free PMC article.

10

Muscarinic receptor M₄ positive allosteric modulators attenuate central effects of cocaine.

Dall C, Weikop P, Dencker D, Molander AC, Wörtwein G, Conn PJ, Fink-Jensen A, Thomsen M. Dall C, et al. Drug Alcohol Depend. 2017 Jul 1;176:154-161. doi: 10.1016/j.drugalcdep.2017.03.014. Epub 2017 May 16. Drug Alcohol Depend. 2017. PMID: 28544993 Free PMC article.

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