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Items: 1 to 20 of 130

1.

Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin.

Tundo GR, Di Muzio E, Ciaccio C, Sbardella D, Di Pierro D, Polticelli F, Coletta M, Marini S.

FEBS J. 2016 Oct;283(20):3755-3770. doi: 10.1111/febs.13841. Epub 2016 Sep 29.

2.

Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity.

Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M.

J Mol Biol. 2009 Feb 6;385(5):1556-67. doi: 10.1016/j.jmb.2008.11.025. Epub 2008 Nov 25.

PMID:
19073193
3.

Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme.

Guo Q, Manolopoulou M, Bian Y, Schilling AB, Tang WJ.

J Mol Biol. 2010 Jan 15;395(2):430-43. doi: 10.1016/j.jmb.2009.10.072. Epub 2009 Nov 5.

4.

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.

Çakir B, Dağliyan O, Dağyildiz E, Bariş İ, Kavakli IH, Kizilel S, Türkay M.

PLoS One. 2012;7(2):e31787. doi: 10.1371/journal.pone.0031787. Epub 2012 Feb 15.

5.

Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ.

Biochemistry. 2008 Dec 2;47(48):12822-34. doi: 10.1021/bi801192h.

6.

Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides.

Kurochkin IV, Guarnera E, Wong JH, Eisenhaber F, Berezovsky IN.

Biochemistry. 2017 Jan 10;56(1):228-239. doi: 10.1021/acs.biochem.6b00783. Epub 2016 Dec 16.

PMID:
27982586
7.

Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation.

Song ES, Cady C, Fried MG, Hersh LB.

Biochemistry. 2006 Dec 19;45(50):15085-91.

8.

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

Shen Y, Joachimiak A, Rosner MR, Tang WJ.

Nature. 2006 Oct 19;443(7113):870-4. Epub 2006 Oct 11.

9.

Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme.

Stefanidis L, Fusco ND, Cooper SE, Smith-Carpenter JE, Alper BJ.

Biochemistry. 2018 Aug 14;57(32):4903-4914. doi: 10.1021/acs.biochem.8b00474. Epub 2018 Jul 25.

PMID:
30004674
10.

A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties.

Song ES, Rodgers DW, Hersh LB.

PLoS One. 2010 Mar 16;5(3):e9719. doi: 10.1371/journal.pone.0009719.

11.

Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.

Tundo G, Ciaccio C, Sbardella D, Boraso M, Viviani B, Coletta M, Marini S.

PLoS One. 2012;7(4):e34376. doi: 10.1371/journal.pone.0034376. Epub 2012 Apr 3.

12.

Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

Song ES, Juliano MA, Juliano L, Hersh LB.

J Biol Chem. 2003 Dec 12;278(50):49789-94. Epub 2003 Oct 2.

13.

Insulysin: an allosteric enzyme as a target for Alzheimer's disease.

Song ES, Hersh LB.

J Mol Neurosci. 2005;25(3):201-6.

PMID:
15800373
14.

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.

McCord LA, Liang WG, Dowdell E, Kalas V, Hoey RJ, Koide A, Koide S, Tang WJ.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13827-32. doi: 10.1073/pnas.1304575110. Epub 2013 Aug 6.

15.

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.

Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ.

J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5.

16.

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.

Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.

Biochemistry. 2005 May 3;44(17):6513-25.

PMID:
15850385
17.

Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.

Alper BJ, Rowse JW, Schmidt WK.

Yeast. 2009 Nov;26(11):595-610. doi: 10.1002/yea.1709.

18.

Ubiquitin is a novel substrate for human insulin-degrading enzyme.

Ralat LA, Kalas V, Zheng Z, Goldman RD, Sosnick TR, Tang WJ.

J Mol Biol. 2011 Feb 25;406(3):454-66. doi: 10.1016/j.jmb.2010.12.026. Epub 2010 Dec 23.

19.

Identification of the allosteric regulatory site of insulysin.

Noinaj N, Bhasin SK, Song ES, Scoggin KE, Juliano MA, Juliano L, Hersh LB, Rodgers DW.

PLoS One. 2011;6(6):e20864. doi: 10.1371/journal.pone.0020864. Epub 2011 Jun 24.

20.

Molecular dynamics simulations reveal a novel mechanism for ATP inhibition of insulin degrading enzyme.

da Cruz CH, Seabra G.

J Chem Inf Model. 2014 May 27;54(5):1380-90. doi: 10.1021/ci400695m. Epub 2014 Apr 22.

PMID:
24697863

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