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27570430,24666267,26341080,25886136,20413299,21163770,24806288,23494461,21129611,19001320,28576857,24830936,19884556,23374602,19738166,22145213,22039088,27605871,21729677,20100961,27879995,24595598,29298682,27422777,29388061,25707609,21632860,19223544,25472647,24626880,24024839,20234366,20010090,21340604,20049644,29024937,24956256,23098991,20130433,20399983,26049686,27780856,26812186,24968756,35767139,26318427,21772090,25861836,23182985,20550522,25520391,23158210,19366826,23152013,25989278,25337237,25155261,23325582,26991109,25892888,21671463,26508446,31952366,23099994,27878357,29937183,21474966,23435830,33203645,28972961,36942906,29470838,28032593,30739887,27039744,30199395,33030125,32229076,29631407,28147317,29866615,28368335,26347132,27314237,26438111,30691487,20432670,32098826,20383783,30623370,31912793,25374966,31553708,28249840,27332557,29703253,26869800,32839411,27344184,21139621,35650607,19917537,20718705,28752777,28507280,29589315,24758538,36717006,30545991,32700762,31220949,28685592,23776587,33237690,26355231,28005260,33465286,27002940,20619738,27296403,36288238,34081760,30623369,30487126,31515458,30096327,22409860,33259157,29179247,25777075,36046960,31834556,31587152,29737864,29136952,28262927,24152305,24676216,32943459,28110551,33775193,35438321,25993166,28323034,20034867,28473715,36131281,28747067,36007218,31952666,24744578,30968289,32665850,26849815,28363756,24755613,33906293,26426205,36591710,27555788,31347092,34641699,26920031,31519572,31678702,30612313,30545999,30549033,20222160,27091467,30101612,28382467,31878812,29478126,33825902,33832365,32108374,24876815,31705176,22987994,30905200,30081606,24158971,31376243,28778958,19954416,27747083,28133136,35544729,30623365,19537845,30427914,20595818,29788610,23980047,26872400,27017409,27777877,34894715,32726923,32474402,30252132,23066310,33224365,19047277,27611608,29337243,33212364,21373987,28328955,25663927,26452385,29700206,32946312,29045527,24574764,25206276,28946014,19620792,27010906,36156476,33562755,28302330,27436848,29563631,20943604,29563632,21779535,27409671,30256829,32648137,29783412,26029459,30364934,26150735,26107237,29788743,31537838,28708103,34202896,30019590,31167268,29279095,30758881,33384243,31819705,23817698,33499047,20133499,26770060,17520579,32155907,26909137,31500431,26355234,36410093,34315006,28978055,26327923,33868486,30733075,35128137,35171350,28714940,28765689,27154421,20524863,29414818,27578007,28220124,28685087,31298142,32330071,28105615,20300583,24294007,23997940,29796712,32763752,24003339,34169732,31786838,34156520,35780916,35133234,31099678,29078210,29708446,33322618,31475851,34988329,33920531,36259230,26798432,31388315,36979659,28412781,30863179,18413824,24206589,28435294,24423944,30073926,36046264,30231342,34211852,31279594,33152998,27917697,24458880,35228040,29351242,25636446,35158793,32796636,28165299,34572729,36465407,23207797,32133314,26508880,20584808,28403349,29194036,36497403,31218949,30294606,30207665,30736475,19361405,21874108,31433498,25580262,27380959,27803597,23922463,35580290,28561718,32722130,27843640,22740969,28813639,27398239,28903907,35251973,27747084,28972570,28736628,11597399,23264846,27658254,34675090,32759276,25139340,23323915,23323914,20921207,33102237,28207112,30100989,29568913,30510457,32782486,36187383,35111681,20724833,30519327,26676107,15382104,25210463,32536221,31500426,30151276,31717544,32612957,31169290,28185757,19237831,22065002,30858928,23091721,33585439,23323913,29312811,32825275,34326875,32914007,32053874,33216064,35472088,12421725,29270051,34944853,29911107,33238500,21233242,31550189,34267639,33364187,29049531,30477151,22063461,23356214,29636987,30976712,30602942,7727852,27099699,27493945,23094728,29103530,31602389,28740573,36619267,21874115,30646508,18185468,29783375,32707813,27340376,29118555,29657263,19747113,30069479,31232659,24212803,33820776,16699610,37127538,30027205,36432658,36230757,25525412,29899390,21403829,34894516,28280626,28138633,24212777,27803741,28626361,28579913,26869404,24212785,27843629,31354963,28423771,32617278,37133241,34236898,23316197,21829762,22666589,36011056,27864874,27184380,27722749,30713831,35111688,30271198,24764486,32256579,30225389,23346505,30052765,22811809,12876604,19750187,31848488[uid]

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Year	Number of Results
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Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy.

Lo Nigro C, Ricci V, Vivenza D, Granetto C, Fabozzi T, Miraglio E, Merlano MC. Lo Nigro C, et al. World J Gastroenterol. 2016 Aug 14;22(30):6944-54. doi: 10.3748/wjg.v22.i30.6944. World J Gastroenterol. 2016. PMID: 27570430 Free PMC article. Review.

The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis.

Therkildsen C, Bergmann TK, Henrichsen-Schnack T, Ladelund S, Nilbert M. Therkildsen C, et al. Acta Oncol. 2014 Jul;53(7):852-64. doi: 10.3109/0284186X.2014.895036. Epub 2014 Mar 25. Acta Oncol. 2014. PMID: 24666267 Review.

Prognostic Value of BRAF, PI3K, PTEN, EGFR Copy Number, Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy.

Llovet P, Sastre J, Ortega JS, Bando I, Ferrer M, García-Alfonso P, Donnay O, Carrato A, Jiménez A, Aranda E, León A, Grávalos C, Cámara JC, Feliú J, Sanchíz B, Caldés T, Díaz-Rubio E. Llovet P, et al. Mol Diagn Ther. 2015 Dec;19(6):397-408. doi: 10.1007/s40291-015-0165-0. Mol Diagn Ther. 2015. PMID: 26341080

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer.

Kawazoe A, Shitara K, Fukuoka S, Kuboki Y, Bando H, Okamoto W, Kojima T, Fuse N, Yamanaka T, Doi T, Ohtsu A, Yoshino T. Kawazoe A, et al. BMC Cancer. 2015 Apr 11;15:258. doi: 10.1186/s12885-015-1276-z. BMC Cancer. 2015. PMID: 25886136 Free PMC article.

Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.

Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, Vink-Börger ME, van Cleef PH, van Krieken JH, Punt CJ, Nagtegaal ID. Tol J, et al. Eur J Cancer. 2010 Jul;46(11):1997-2009. doi: 10.1016/j.ejca.2010.03.036. Epub 2010 Apr 21. Eur J Cancer. 2010. PMID: 20413299 Clinical Trial.

Predictive and prognostic factors in the complex treatment of patients with colorectal cancer.

László L. László L. Magy Onkol. 2010 Dec;54(4):383-94. doi: 10.1556/MOnkol.54.2010.4.13. Magy Onkol. 2010. PMID: 21163770 Free article.

Role of NRAS mutations as prognostic and predictive markers in metastatic colorectal cancer.

Schirripa M, Cremolini C, Loupakis F, Morvillo M, Bergamo F, Zoratto F, Salvatore L, Antoniotti C, Marmorino F, Sensi E, Lupi C, Fontanini G, De Gregorio V, Giannini R, Basolo F, Masi G, Falcone A. Schirripa M, et al. Int J Cancer. 2015 Jan 1;136(1):83-90. doi: 10.1002/ijc.28955. Epub 2014 May 28. Int J Cancer. 2015. PMID: 24806288 Free article.

Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: a systematic review with meta-analysis.

Yang ZY, Wu XY, Huang YF, Di MY, Zheng DY, Chen JZ, Ding H, Mao C, Tang JL. Yang ZY, et al. Int J Cancer. 2013 Oct 15;133(8):1914-25. doi: 10.1002/ijc.28153. Epub 2013 Jul 13. Int J Cancer. 2013. PMID: 23494461 Free article. Review.

Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?

Rizzo S, Bronte G, Fanale D, Corsini L, Silvestris N, Santini D, Gulotta G, Bazan V, Gebbia N, Fulfaro F, Russo A. Rizzo S, et al. Cancer Treat Rev. 2010 Nov;36 Suppl 3:S56-61. doi: 10.1016/S0305-7372(10)70021-9. Cancer Treat Rev. 2010. PMID: 21129611 Review.

Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.

Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A. Di Nicolantonio F, et al. J Clin Oncol. 2008 Dec 10;26(35):5705-12. doi: 10.1200/JCO.2008.18.0786. Epub 2008 Nov 10. J Clin Oncol. 2008. PMID: 19001320 Free article.

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