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Medullary thymic epithelial cells and CD8α+ dendritic cells coordinately regulate central tolerance but CD8α+ cells are dispensable for thymic regulatory T cell production.

Herbin O, Bonito AJ, Jeong S, Weinstein EG, Rahman AH, Xiong H, Merad M, Alexandropoulos K.

J Autoimmun. 2016 Dec;75:141-149. doi: 10.1016/j.jaut.2016.08.002. Epub 2016 Aug 16.


Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance.

Perry JSA, Russler-Germain EV, Zhou YW, Purtha W, Cooper ML, Choi J, Schroeder MA, Salazar V, Egawa T, Lee BC, Abumrad NA, Kim BS, Anderson MS, DiPersio JF, Hsieh CS.

Immunity. 2018 May 15;48(5):923-936.e4. doi: 10.1016/j.immuni.2018.04.007. Epub 2018 May 8. Erratum in: Immunity. 2018 Jun 19;48(6):1271.


Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner.

Baba T, Nakamoto Y, Mukaida N.

J Immunol. 2009 Sep 1;183(5):3053-63. doi: 10.4049/jimmunol.0900438. Epub 2009 Aug 12.


Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.

Riemann M, Andreas N, Fedoseeva M, Meier E, Weih D, Freytag H, Schmidt-Ullrich R, Klein U, Wang ZQ, Weih F.

J Autoimmun. 2017 Jul;81:56-67. doi: 10.1016/j.jaut.2017.03.007. Epub 2017 Apr 3.


Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus.

Perry JSA, Lio CJ, Kau AL, Nutsch K, Yang Z, Gordon JI, Murphy KM, Hsieh CS.

Immunity. 2014 Sep 18;41(3):414-426. doi: 10.1016/j.immuni.2014.08.007. Epub 2014 Sep 11.


Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance.

Lancaster JN, Thyagarajan HM, Srinivasan J, Li Y, Hu Z, Ehrlich LIR.

Nat Commun. 2019 May 17;10(1):2220. doi: 10.1038/s41467-019-09727-4.


Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.

Atibalentja DF, Murphy KM, Unanue ER.

J Immunol. 2011 Feb 1;186(3):1421-31. doi: 10.4049/jimmunol.1002587. Epub 2010 Dec 22.


Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.

Coquet JM, Ribot JC, Bąbała N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D, Jacobs H, Pennington DJ, Silva-Santos B, Borst J.

J Exp Med. 2013 Apr 8;210(4):715-28. doi: 10.1084/jem.20112061. Epub 2013 Apr 1.


Redefining thymus medulla specialization for central tolerance.

Cosway EJ, Lucas B, James KD, Parnell SM, Carvalho-Gaspar M, White AJ, Tumanov AV, Jenkinson WE, Anderson G.

J Exp Med. 2017 Nov 6;214(11):3183-3195. doi: 10.1084/jem.20171000. Epub 2017 Aug 22.


The thymic medulla: a unique microenvironment for intercellular self-antigen transfer.

Koble C, Kyewski B.

J Exp Med. 2009 Jul 6;206(7):1505-13. doi: 10.1084/jem.20082449. Epub 2009 Jun 29.


Medullary thymic epithelial cell depletion leads to autoimmune hepatitis.

Bonito AJ, Aloman C, Fiel MI, Danzl NM, Cha S, Weinstein EG, Jeong S, Choi Y, Walsh MC, Alexandropoulos K.

J Clin Invest. 2013 Aug;123(8):3510-24. doi: 10.1172/JCI65414. Epub 2013 Jul 15.


Medullary thymic epithelial cells, the indispensable player in central tolerance.

Shi Y, Zhu M.

Sci China Life Sci. 2013 May;56(5):392-8. doi: 10.1007/s11427-013-4482-4. Epub 2013 May 1. Review.


Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J.

Oncotarget. 2017 May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.


Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen.

Mouri Y, Ueda Y, Yamano T, Matsumoto M, Tsuneyama K, Kinashi T, Matsumoto M.

J Immunol. 2017 Dec 15;199(12):3959-3971. doi: 10.4049/jimmunol.1700892. Epub 2017 Nov 3.


Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells.

Aschenbrenner K, D'Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, Swee LK, Rolink A, Klein L.

Nat Immunol. 2007 Apr;8(4):351-8. Epub 2007 Feb 25.


Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance.

Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS.

J Exp Med. 2014 May 5;211(5):761-8. doi: 10.1084/jem.20131889. Epub 2014 Apr 21.


Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand.

Nazzal D, Gradolatto A, Truffault F, Bismuth J, Berrih-Aknin S.

Cell Death Dis. 2014 Sep 11;5:e1420. doi: 10.1038/cddis.2014.377.


Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance.

Klein L, Hinterberger M, von Rohrscheidt J, Aichinger M.

Trends Immunol. 2011 May;32(5):188-93. doi: 10.1016/ Epub 2011 Apr 12.


Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

Hubert FX, Kinkel SA, Davey GM, Phipson B, Mueller SN, Liston A, Proietto AI, Cannon PZ, Forehan S, Smyth GK, Wu L, Goodnow CC, Carbone FR, Scott HS, Heath WR.

Blood. 2011 Sep 1;118(9):2462-72. doi: 10.1182/blood-2010-06-286393. Epub 2011 Apr 19.


NF-κB-inducing kinase in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells.

Mouri Y, Nishijima H, Kawano H, Hirota F, Sakaguchi N, Morimoto J, Matsumoto M.

J Immunol. 2014 Nov 1;193(9):4356-67. doi: 10.4049/jimmunol.1400389. Epub 2014 Sep 26.

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