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Items: 1 to 20 of 76

1.

Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.

Segaoula Z, Leclercq J, Verones V, Flouquet N, Lecoeur M, Ach L, Renault N, Barczyk A, Melnyk P, Berthelot P, Thuru X, Lebegue N.

J Med Chem. 2016 Sep 22;59(18):8422-40. doi: 10.1021/acs.jmedchem.6b00847. Epub 2016 Aug 30.

PMID:
27538123
2.

Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.

Wang F, Yang Z, Liu Y, Ma L, Wu Y, He L, Shao M, Yu K, Wu W, Pu Y, Nie C, Chen L.

Bioorg Med Chem. 2015 Jul 1;23(13):3337-50. doi: 10.1016/j.bmc.2015.04.055. Epub 2015 Apr 24.

PMID:
25937236
3.

Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site.

Wang XF, Guan F, Ohkoshi E, Guo W, Wang L, Zhu DQ, Wang SB, Wang LT, Hamel E, Yang D, Li L, Qian K, Morris-Natschke SL, Yuan S, Lee KH, Xie L.

J Med Chem. 2014 Feb 27;57(4):1390-402. doi: 10.1021/jm4016526. Epub 2014 Feb 6.

4.

Discovery of novel 2-N-aryl-substituted benzenesulfonamidoacetamides: orally bioavailable tubulin polymerization inhibitors with marked antitumor activities.

Liu Z, Zhou Z, Tian W, Fan X, Xue D, Yu L, Yu Q, Long YQ.

ChemMedChem. 2012 Apr;7(4):680-93. doi: 10.1002/cmdc.201100529. Epub 2012 Feb 6.

PMID:
22311585
5.

Synthesis and cytotoxic activity of 2-anilinopyridine-3-acrylamides as tubulin polymerization inhibitors.

Kamal A, Ashraf M, Khan MN, Nimbarte VD, Faazil S, Subba Reddy NV, Taj S.

ChemMedChem. 2014 Mar 28. doi: 10.1002/cmdc.201400036. Epub 2014 Mar 28. Retraction in: ChemMedChem. 2014 Jul;9(7):1615.

PMID:
24683000
6.

Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors.

Mahesh R, Nayak VL, Babu KS, Riyaz S, Shaik TB, Kumar GB, Mallipeddi PL, Reddy CR, Shekar KC, Jose J, Nagesh N, Kamal A.

ChemMedChem. 2017 May 9;12(9):678-700. doi: 10.1002/cmdc.201600643. Epub 2017 Apr 13.

PMID:
28276645
7.

Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.

Pinney KG, Mejia MP, Villalobos VM, Rosenquist BE, Pettit GR, Verdier-Pinard P, Hamel E.

Bioorg Med Chem. 2000 Oct;8(10):2417-25.

PMID:
11058036
8.
9.

Novel 2-methoxyestradiol analogues with antitumor activity.

Tinley TL, Leal RM, Randall-Hlubek DA, Cessac JW, Wilkens LR, Rao PN, Mooberry SL.

Cancer Res. 2003 Apr 1;63(7):1538-49.

10.

Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.

Ty N, Dupeyre G, Chabot GG, Seguin J, Tillequin F, Scherman D, Michel S, Cachet X.

Bioorg Med Chem. 2008 Aug 1;16(15):7494-503. doi: 10.1016/j.bmc.2008.06.002. Epub 2008 Jun 7.

PMID:
18583138
11.

The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo.

Burns CJ, Fantino E, Powell AK, Shnyder SD, Cooper PA, Nelson S, Christophi C, Malcontenti-Wilson C, Dubljevic V, Harte MF, Joffe M, Phillips ID, Segal D, Wilks AF, Smith GD.

J Pharmacol Exp Ther. 2011 Dec;339(3):799-806. doi: 10.1124/jpet.111.186965. Epub 2011 Sep 14.

12.

Novel benzopyridothiadiazepines as potential active antitumor agents.

Lebegue N, Gallet S, Flouquet N, Carato P, Pfeiffer B, Renard P, Léonce S, Pierré A, Chavatte P, Berthelot P.

J Med Chem. 2005 Nov 17;48(23):7363-73.

PMID:
16279796
13.

Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors.

Yang Z, Wu W, Wang J, Liu L, Li L, Yang J, Wang G, Cao D, Zhang R, Tang M, Wen J, Zhu J, Xiang W, Wang F, Ma L, Xiang M, You J, Chen L.

J Med Chem. 2014 Oct 9;57(19):7977-89. doi: 10.1021/jm500849z. Epub 2014 Sep 29.

PMID:
25208345
14.

Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.

Mahboobi S, Pongratz H, Hufsky H, Hockemeyer J, Frieser M, Lyssenko A, Paper DH, Bürgermeister J, Böhmer FD, Fiebig HH, Burger AM, Baasner S, Beckers T.

J Med Chem. 2001 Dec 20;44(26):4535-53.

PMID:
11741473
15.

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E.

J Med Chem. 1992 Jun 12;35(12):2293-306.

PMID:
1613753
16.

Chemosensitization and radiosensitization of human lung and colon cancers by antimitotic agent, ABT-751, in athymic murine xenograft models of subcutaneous tumor growth.

Jorgensen TJ, Tian H, Joseph IB, Menon K, Frost D.

Cancer Chemother Pharmacol. 2007 May;59(6):725-32. Epub 2006 Sep 12.

PMID:
16967299
17.

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.

Wang G, Peng F, Cao D, Yang Z, Han X, Liu J, Wu W, He L, Ma L, Chen J, Sang Y, Xiang M, Peng A, Wei Y, Chen L.

Bioorg Med Chem. 2013 Nov 1;21(21):6844-54. doi: 10.1016/j.bmc.2013.02.002. Epub 2013 Feb 13.

PMID:
23993668
18.

Discovery of azaisoerianin derivatives as potential antitumors agents.

Soussi MA, Provot O, Bernadat G, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Messaoudi S, Alami M.

Eur J Med Chem. 2014 May 6;78:178-89. doi: 10.1016/j.ejmech.2014.03.032. Epub 2014 Mar 13.

PMID:
24681982
19.

Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors.

Kamal A, Kumar GB, Polepalli S, Shaik AB, Reddy VS, Reddy MK, Reddy ChR, Mahesh R, Kapure JS, Jain N.

ChemMedChem. 2014 Nov;9(11):2565-79. doi: 10.1002/cmdc.201402256. Epub 2014 Aug 21.

PMID:
25146959
20.

Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors.

Kamal A, Srinivasa Reddy T, Polepalli S, Shalini N, Reddy VG, Subba Rao AV, Jain N, Shankaraiah N.

Bioorg Med Chem. 2014 Oct 1;22(19):5466-75. doi: 10.1016/j.bmc.2014.07.031. Epub 2014 Jul 27.

PMID:
25131956

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