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Items: 1 to 20 of 183

1.

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.

Ma-Lauer Y, Carbajo-Lozoya J, Hein MY, Müller MA, Deng W, Lei J, Meyer B, Kusov Y, von Brunn B, Bairad DR, Hünten S, Drosten C, Hermeking H, Leonhardt H, Mann M, Hilgenfeld R, von Brunn A.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5192-201. doi: 10.1073/pnas.1603435113. Epub 2016 Aug 12.

2.

The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.

Báez-Santos YM, St John SE, Mesecar AD.

Antiviral Res. 2015 Mar;115:21-38. doi: 10.1016/j.antiviral.2014.12.015. Epub 2014 Dec 29. Review.

3.

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.

Taylor JK, Coleman CM, Postel S, Sisk JM, Bernbaum JG, Venkataraman T, Sundberg EJ, Frieman MB.

J Virol. 2015 Dec;89(23):11820-33. doi: 10.1128/JVI.02274-15. Epub 2015 Sep 16.

4.

Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.

Báez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD.

J Virol. 2014 Nov;88(21):12511-27. doi: 10.1128/JVI.01294-14. Epub 2014 Aug 20.

5.

Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.

Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL.

J Biol Chem. 2014 Dec 12;289(50):34667-82. doi: 10.1074/jbc.M114.609644. Epub 2014 Oct 15.

6.

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease.

Yang X, Chen X, Bian G, Tu J, Xing Y, Wang Y, Chen Z.

J Gen Virol. 2014 Mar;95(Pt 3):614-26. doi: 10.1099/vir.0.059014-0. Epub 2013 Dec 20.

PMID:
24362959
7.

The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme.

Lindner HA, Fotouhi-Ardakani N, Lytvyn V, Lachance P, Sulea T, Ménard R.

J Virol. 2005 Dec;79(24):15199-208.

8.

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.

Ratia K, Kilianski A, Baez-Santos YM, Baker SC, Mesecar A.

PLoS Pathog. 2014 May 22;10(5):e1004113. doi: 10.1371/journal.ppat.1004113. eCollection 2014 May.

9.

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.

Hu Y, Li W, Gao T, Cui Y, Jin Y, Li P, Ma Q, Liu X, Cao C.

J Virol. 2017 Mar 29;91(8). pii: e02143-16. doi: 10.1128/JVI.02143-16. Print 2017 Apr 15.

10.

Molecular Dynamic Studies of Interferon and Innate Immunity Resistance in MERS CoV Non-Structural Protein 3.

Alfuwaires M, Altaher A, Kandeel M.

Biol Pharm Bull. 2017;40(3):345-351. doi: 10.1248/bpb.b16-00870.

11.

The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes.

Tan J, Vonrhein C, Smart OS, Bricogne G, Bollati M, Kusov Y, Hansen G, Mesters JR, Schmidt CL, Hilgenfeld R.

PLoS Pathog. 2009 May;5(5):e1000428. doi: 10.1371/journal.ppat.1000428. Epub 2009 May 15.

12.

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.

Menachery VD, Yount BL Jr, Josset L, Gralinski LE, Scobey T, Agnihothram S, Katze MG, Baric RS.

J Virol. 2014 Apr;88(8):4251-64. doi: 10.1128/JVI.03571-13. Epub 2014 Jan 29.

13.

Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.

Sun L, Xing Y, Chen X, Zheng Y, Yang Y, Nichols DB, Clementz MA, Banach BS, Li K, Baker SC, Chen Z.

PLoS One. 2012;7(2):e30802. doi: 10.1371/journal.pone.0030802. Epub 2012 Feb 1.

14.

Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus.

Devaraj SG, Wang N, Chen Z, Chen Z, Tseng M, Barretto N, Lin R, Peters CJ, Tseng CT, Baker SC, Li K.

J Biol Chem. 2007 Nov 2;282(44):32208-21. Epub 2007 Aug 30.

15.

The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species.

Niemeyer D, Mösbauer K, Klein EM, Sieberg A, Mettelman RC, Mielech AM, Dijkman R, Baker SC, Drosten C, Müller MA.

PLoS Pathog. 2018 Sep 24;14(9):e1007296. doi: 10.1371/journal.ppat.1007296. eCollection 2018 Sep.

16.

Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.

Lee H, Lei H, Santarsiero BD, Gatuz JL, Cao S, Rice AJ, Patel K, Szypulinski MZ, Ojeda I, Ghosh AK, Johnson ME.

ACS Chem Biol. 2015 Jun 19;10(6):1456-65. doi: 10.1021/cb500917m. Epub 2015 Mar 16.

17.

Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus.

Daczkowski CM, Goodwin OY, Dzimianski JV, Farhat JJ, Pegan SD.

J Virol. 2017 Nov 14;91(23). pii: e01067-17. doi: 10.1128/JVI.01067-17. Print 2017 Dec 1.

18.

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24. doi: 10.1073/pnas.0805240105. Epub 2008 Oct 13.

19.

A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex.

Kusov Y, Tan J, Alvarez E, Enjuanes L, Hilgenfeld R.

Virology. 2015 Oct;484:313-22. doi: 10.1016/j.virol.2015.06.016. Epub 2015 Jul 3.

20.

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.

Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC.

J Virol. 2005 Dec;79(24):15189-98.

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