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Loss of the Par3 Polarity Protein Promotes Breast Tumorigenesis and Metastasis.

McCaffrey LM, Montalbano J, Mihai C, Macara IG.

Cancer Cell. 2016 Aug 8;30(2):351-352. doi: 10.1016/j.ccell.2016.07.001. Epub 2016 Aug 8. No abstract available.


Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.

McCaffrey LM, Montalbano J, Mihai C, Macara IG.

Cancer Cell. 2012 Nov 13;22(5):601-14. doi: 10.1016/j.ccr.2012.10.003. Erratum in: Cancer Cell. 2016 Aug 8;30(2):351-352.


Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3.

Archibald A, Mihai C, Macara IG, McCaffrey L.

Oncogene. 2015 Jun 11;34(24):3199-206. doi: 10.1038/onc.2014.242. Epub 2014 Aug 11.


Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.

Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK.

Nat Cell Biol. 2013 Feb;15(2):189-200. doi: 10.1038/ncb2663. Epub 2012 Dec 23.


Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition.

Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH, Gao WQ.

Oncogene. 2016 Mar 10;35(10):1271-82. doi: 10.1038/onc.2015.184. Epub 2015 Jun 8.


Par3 regulates invasion of pancreatic cancer cells via interaction with Tiam1.

Guo X, Wang M, Zhao Y, Wang X, Shen M, Zhu F, Shi C, Xu M, Li X, Peng F, Zhang H, Feng Y, Xie Y, Xu X, Jia W, He R, Jiang J, Hu J, Tian R, Qin R.

Clin Exp Med. 2016 Aug;16(3):357-65. doi: 10.1007/s10238-015-0365-2. Epub 2015 Jun 18.


Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.

Iden S, van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG.

Cancer Cell. 2012 Sep 11;22(3):389-403. doi: 10.1016/j.ccr.2012.08.004.


The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.

Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG.

Mol Cell. 2012 Aug 10;47(3):469-83. doi: 10.1016/j.molcel.2012.06.037.


Human papillomavirus (HPV)-18 E6 oncoprotein interferes with the epithelial cell polarity Par3 protein.

Facciuto F, Bugnon Valdano M, Marziali F, Massimi P, Banks L, Cavatorta AL, Gardiol D.

Mol Oncol. 2014 May;8(3):533-43. doi: 10.1016/j.molonc.2014.01.002. Epub 2014 Jan 14.


Dual function of partitioning-defective 3 in the regulation of YAP phosphorylation and activation.

Zhang P, Wang S, Wang S, Qiao J, Zhang L, Zhang Z, Chen Z.

Cell Discov. 2016 Jul 5;2:16021. doi: 10.1038/celldisc.2016.21. eCollection 2016.


Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells.

Zhou Y, Fang L, Du D, Zhou W, Feng X, Chen J, Zhang Z, Chen Z.

Acta Biochim Biophys Sin (Shanghai). 2008 Aug;40(8):729-39.


Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.

Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML.

Dev Cell. 2010 Jan 19;18(1):39-51. doi: 10.1016/j.devcel.2009.12.006.


Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.

Li J, Liu J, Li P, Mao X, Li W, Yang J, Liu P.

J Exp Clin Cancer Res. 2014 Sep 2;33:70. doi: 10.1186/s13046-014-0070-0.


Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway.

Yang R, Kong E, Jin J, Hergovich A, Püschel AW.

J Cell Sci. 2014 Aug 15;127(Pt 16):3463-76. doi: 10.1242/jcs.146696. Epub 2014 Jun 13.


Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair.

Fang L, Wang Y, Du D, Yang G, Tak Kwok T, Kai Kong S, Chen B, Chen DJ, Chen Z.

Cell Res. 2007 Feb;17(2):100-16. Erratum in: Cell Res. 2007 Jun;17(6):572-4.


Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis.

Wong EW, Mruk DD, Lee WM, Cheng CY.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9657-62. doi: 10.1073/pnas.0801527105. Epub 2008 Jul 10.


Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis.

Itoh N, Nakayama M, Nishimura T, Fujisue S, Nishioka T, Watanabe T, Kaibuchi K.

Cytoskeleton (Hoboken). 2010 May;67(5):297-308. doi: 10.1002/cm.20444.


Distal interactions within the par3-VE-cadherin complex.

Tyler RC, Peterson FC, Volkman BF.

Biochemistry. 2010 Feb 9;49(5):951-7. doi: 10.1021/bi9017335.


The Par3-like polarity protein Par3L is essential for mammary stem cell maintenance.

Huo Y, Macara IG.

Nat Cell Biol. 2014 Jun;16(6):529-37. doi: 10.1038/ncb2969. Epub 2014 May 25. Erratum in: Nat Cell Biol. 2014 Jul;16(7):716.


LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway.

Li X, Yang Q, Yu H, Wu L, Zhao Y, Zhang C, Yue X, Liu Z, Wu H, Haffty BG, Feng Z, Hu W.

Oncotarget. 2014 Feb 15;5(3):788-801.

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