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Items: 1 to 20 of 142

1.

Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication.

Olsen ME, Filone CM, Rozelle D, Mire CE, Agans KN, Hensley L, Connor JH.

MBio. 2016 Jul 26;7(4). pii: e00882-16. doi: 10.1128/mBio.00882-16. Erratum in: MBio. 2018 Jun 5;9(3):.

2.

Differential Mechanisms for the Involvement of Polyamines and Hypusinated eIF5A in Ebola Virus Gene Expression.

Olsen ME, Cressey TN, M├╝hlberger E, Connor JH.

J Virol. 2018 Sep 26;92(20). pii: e01260-18. doi: 10.1128/JVI.01260-18. Print 2018 Oct 15.

PMID:
30045993
3.

Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.

Schultz CR, Geerts D, Mooney M, El-Khawaja R, Koster J, Bachmann AS.

Biochem J. 2018 Jan 31;475(2):531-545. doi: 10.1042/BCJ20170597.

PMID:
29295892
4.

Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription.

Ilinykh PA, Tigabu B, Ivanov A, Ammosova T, Obukhov Y, Garron T, Kumari N, Kovalskyy D, Platonov MO, Naumchik VS, Freiberg AN, Nekhai S, Bukreyev A.

J Biol Chem. 2014 Aug 15;289(33):22723-38. doi: 10.1074/jbc.M114.575050. Epub 2014 Jun 16.

5.

Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins.

Nguyen S, Leija C, Kinch L, Regmi S, Li Q, Grishin NV, Phillips MA.

J Biol Chem. 2015 Aug 7;290(32):19987-98. doi: 10.1074/jbc.M115.656785. Epub 2015 Jun 16.

6.

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.

Bharaj P, Atkins C, Luthra P, Giraldo MI, Dawes BE, Miorin L, Johnson JR, Krogan NJ, Basler CF, Freiberg AN, Rajsbaum R.

J Virol. 2017 Aug 24;91(18). pii: e00833-17. doi: 10.1128/JVI.00833-17. Print 2017 Sep 15.

7.

RNA Binding of Ebola Virus VP30 Is Essential for Activating Viral Transcription.

Biedenkopf N, Schlereth J, Gr├╝nweller A, Becker S, Hartmann RK.

J Virol. 2016 Jul 27;90(16):7481-7496. doi: 10.1128/JVI.00271-16. Print 2016 Aug 15.

9.

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.

Oliverio S, Corazzari M, Sestito C, Piredda L, Ippolito G, Piacentini M.

Amino Acids. 2014 Dec;46(12):2767-76. doi: 10.1007/s00726-014-1821-0. Epub 2014 Sep 14.

PMID:
25218134
10.

DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome.

Takahashi K, Halfmann P, Oyama M, Kozuka-Hata H, Noda T, Kawaoka Y.

J Virol. 2013 Aug;87(16):8862-9. doi: 10.1128/JVI.03544-12. Epub 2013 May 8.

11.

Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer.

Nakanishi S, Cleveland JL.

Amino Acids. 2016 Oct;48(10):2353-62. doi: 10.1007/s00726-016-2275-3. Epub 2016 Jun 29. Review.

12.

Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.

Hoque M, Hanauske-Abel HM, Palumbo P, Saxena D, D'Alliessi Gandolfi D, Park MH, Pe'ery T, Mathews MB.

Retrovirology. 2009 Oct 13;6:90. doi: 10.1186/1742-4690-6-90.

13.

Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).

Lee SB, Park JH, Folk JE, Deck JA, Pegg AE, Sokabe M, Fraser CS, Park MH.

Biochem J. 2011 Jan 1;433(1):205-13. doi: 10.1042/BJ20101322.

14.

Comparative Transcriptomics Highlights the Role of the Activator Protein 1 Transcription Factor in the Host Response to Ebolavirus.

Wynne JW, Todd S, Boyd V, Tachedjian M, Klein R, Shiell B, Dearnley M, McAuley AJ, Woon AP, Purcell AW, Marsh GA, Baker ML.

J Virol. 2017 Nov 14;91(23). pii: e01174-17. doi: 10.1128/JVI.01174-17. Print 2017 Dec 1.

15.

Role of VP30 phosphorylation in the Ebola virus replication cycle.

Martinez MJ, Volchkova VA, Raoul H, Alazard-Dany N, Reynard O, Volchkov VE.

J Infect Dis. 2011 Nov;204 Suppl 3:S934-40. doi: 10.1093/infdis/jir320.

PMID:
21987772
16.

Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.

Herbert AS, Davidson C, Kuehne AI, Bakken R, Braigen SZ, Gunn KE, Whelan SP, Brummelkamp TR, Twenhafel NA, Chandran K, Walkley SU, Dye JM.

MBio. 2015 May 26;6(3):e00565-15. doi: 10.1128/mBio.00565-15.

17.

Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.

Wolff EC, Kang KR, Kim YS, Park MH.

Amino Acids. 2007 Aug;33(2):341-50. Epub 2007 May 4. Review.

18.

The effect of hypusine modification on the intracellular localization of eIF5A.

Lee SB, Park JH, Kaevel J, Sramkova M, Weigert R, Park MH.

Biochem Biophys Res Commun. 2009 Jun 12;383(4):497-502. doi: 10.1016/j.bbrc.2009.04.049. Epub 2009 Apr 18.

19.

Hypusine, a polyamine-derived amino acid critical for eukaryotic translation.

Park MH, Wolff EC.

J Biol Chem. 2018 Nov 30;293(48):18710-18718. doi: 10.1074/jbc.TM118.003341. Epub 2018 Sep 26. Review.

PMID:
30257869
20.

Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine.

Chattopadhyay MK, Park MH, Tabor H.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6554-9. doi: 10.1073/pnas.0710970105. Epub 2008 May 1.

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