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Items: 1 to 20 of 115

1.

Hypoxia inducible factor-1α regulates a pro-invasive phenotype in acute monocytic leukemia.

Migliavacca J, Percio S, Valsecchi R, Ferrero E, Spinelli A, Ponzoni M, Tresoldi C, Pattini L, Bernardi R, Coltella N.

Oncotarget. 2016 Aug 16;7(33):53540-53557. doi: 10.18632/oncotarget.10660.

2.

HIF-1α can act as a tumor suppressor gene in murine acute myeloid leukemia.

Velasco-Hernandez T, Hyrenius-Wittsten A, Rehn M, Bryder D, Cammenga J.

Blood. 2014 Dec 4;124(24):3597-607. doi: 10.1182/blood-2014-04-567065. Epub 2014 Sep 29.

PMID:
25267197
3.

Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy.

Spinello I, Quaranta MT, Paolillo R, Pelosi E, Cerio AM, Saulle E, Lo Coco F, Testa U, Labbaye C.

Haematologica. 2015 Sep;100(9):1160-71. doi: 10.3324/haematol.2014.120295. Epub 2015 Jun 4.

4.

HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia.

Zhe N, Chen S, Zhou Z, Liu P, Lin X, Yu M, Cheng B, Zhang Y, Wang J.

Cancer Biol Ther. 2016 Jun 2;17(6):625-34. doi: 10.1080/15384047.2016.1177679. Epub 2016 Apr 15.

5.

Citrate induces apoptosis of the acute monocytic leukemia U937 cell line through regulation of HIF-1α signaling.

Xu X, Li B, Huang P, Wan X, Qin Y, Zhou L, Liu H, Bai H, Gao Y, Wang C, Meng X.

Mol Med Rep. 2013 Nov;8(5):1379-84. doi: 10.3892/mmr.2013.1702. Epub 2013 Sep 24.

PMID:
24064771
6.

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment.

Frolova O, Samudio I, Benito JM, Jacamo R, Kornblau SM, Markovic A, Schober W, Lu H, Qiu YH, Buglio D, McQueen T, Pierce S, Shpall E, Konoplev S, Thomas D, Kantarjian H, Lock R, Andreeff M, Konopleva M.

Cancer Biol Ther. 2012 Aug;13(10):858-70. doi: 10.4161/cbt.20838. Epub 2012 Aug 1.

7.

Beclin-1 and hypoxia-inducible factor-1α genes expression: Potential biomarkers in acute leukemia patients.

Radwan SM, Hamdy NM, Hegab HM, El-Mesallamy HO.

Cancer Biomark. 2016 Mar 18;16(4):619-26. doi: 10.3233/CBM-160603.

PMID:
27002764
8.

HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment.

Valsecchi R, Coltella N, Belloni D, Ponente M, Ten Hacken E, Scielzo C, Scarfò L, Bertilaccio MT, Brambilla P, Lenti E, Martinelli Boneschi F, Brendolan A, Ferrero E, Ferrarini M, Ghia P, Tonon G, Ponzoni M, Caligaris-Cappio F, Bernardi R.

Blood. 2016 Apr 21;127(16):1987-97. doi: 10.1182/blood-2015-07-657056. Epub 2016 Jan 29.

9.

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patient with acute leukemia via inhibiting the activation of PI3K/Akt and ERK1/2 pathways.

Zeng D, Wang J, Kong P, Chang C, Li J, Li J.

Int J Clin Exp Pathol. 2014 Apr 15;7(5):2172-8. eCollection 2014.

10.

Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer.

He C, Wang L, Zhang J, Xu H.

Mol Cancer. 2017 Feb 7;16(1):35. doi: 10.1186/s12943-017-0603-1.

11.

HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse.

Coltella N, Percio S, Valsecchi R, Cuttano R, Guarnerio J, Ponzoni M, Pandolfi PP, Melillo G, Pattini L, Bernardi R.

EMBO Mol Med. 2014 May;6(5):640-50. doi: 10.1002/emmm.201303065.

12.

Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer.

Cheng CW, Chen PM, Hsieh YH, Weng CC, Chang CW, Yao CC, Hu LY, Wu PE, Shen CY.

Oncotarget. 2015 Dec 29;6(42):44222-38. doi: 10.18632/oncotarget.5826.

13.

[Expression of HIF-1α in primary acute myeloid leukemia cells and its relationship with prognosis].

Chen P, Jiang X, Huang HF, Yuan Q, Wu JY, Guo YF, Chen YZ.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Feb;23(1):19-23. doi: 10.7534/j.issn.1009-2137.2015.01.004. Chinese.

PMID:
25687039
14.

Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells.

Zou J, Li P, Lu F, Liu N, Dai J, Ye J, Qu X, Sun X, Ma D, Park J, Ji C.

J Hematol Oncol. 2013 Jan 5;6:3. doi: 10.1186/1756-8722-6-3.

15.

Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis.

Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.

Cancer Res. 2006 Dec 1;66(23):11263-70.

16.

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.

Warfel NA, Dolloff NG, Dicker DT, Malysz J, El-Deiry WS.

Cell Cycle. 2013 Dec 1;12(23):3689-701. doi: 10.4161/cc.26930. Epub 2013 Oct 25.

17.

Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres.

Méndez O, Zavadil J, Esencay M, Lukyanov Y, Santovasi D, Wang SC, Newcomb EW, Zagzag D.

Mol Cancer. 2010 Jun 1;9:133. doi: 10.1186/1476-4598-9-133.

18.

HIF-1α contributes to proliferation and invasiveness of neuroblastoma cells via SHH signaling.

Chen S, Zhang M, Xing L, Wang Y, Xiao Y, Wu Y.

PLoS One. 2015 Mar 26;10(3):e0121115. doi: 10.1371/journal.pone.0121115. eCollection 2015.

19.

Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent.

Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ.

Oncogene. 2008 Jan 17;27(4):519-27. Epub 2007 Jul 16.

PMID:
17637739
20.

Hypoxia-inducible factor (HIF) 1alpha accumulation and HIF target gene expression are impaired after induction of endotoxin tolerance.

Frede S, Stockmann C, Winning S, Freitag P, Fandrey J.

J Immunol. 2009 May 15;182(10):6470-6. doi: 10.4049/jimmunol.0802378. Retraction in: J Immunol. 2017 Aug 1;199(3):1206.

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