Similar articles for PMID: 27421777

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1

JWH-018 ω-OH, a shared hydroxy metabolite of the two synthetic cannabinoids JWH-018 and AM-2201, undergoes oxidation by alcohol dehydrogenase and aldehyde dehydrogenase enzymes in vitro forming the carboxylic acid metabolite.

Holm NB, Noble C, Linnet K. Holm NB, et al. Toxicol Lett. 2016 Sep 30;259:35-43. doi: 10.1016/j.toxlet.2016.07.007. Epub 2016 Jul 13. Toxicol Lett. 2016. PMID: 27421777

2

Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.

Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH. Chimalakonda KC, et al. Drug Metab Dispos. 2012 Nov;40(11):2174-84. doi: 10.1124/dmd.112.047530. Epub 2012 Aug 17. Drug Metab Dispos. 2012. PMID: 22904561 Free PMC article.

3

Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants.

Patton AL, Seely KA, Yarbrough AL, Fantegrossi W, James LP, McCain KR, Fujiwara R, Prather PL, Moran JH, Radominska-Pandya A. Patton AL, et al. Biochem Biophys Res Commun. 2018 Apr 6;498(3):597-602. doi: 10.1016/j.bbrc.2018.03.028. Epub 2018 Mar 10. Biochem Biophys Res Commun. 2018. PMID: 29522717 Free PMC article.

4

Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism.

Hutter M, Moosmann B, Kneisel S, Auwärter V. Hutter M, et al. J Mass Spectrom. 2013 Jul;48(7):885-94. doi: 10.1002/jms.3229. J Mass Spectrom. 2013. PMID: 23832945

5

In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues.

Davidsen AB, Mardal M, Linnet K. Davidsen AB, et al. AAPS J. 2019 May 15;21(4):63. doi: 10.1208/s12248-019-0338-6. AAPS J. 2019. PMID: 31093790

6

Apparent Affinity Estimates and Reversal of the Effects of Synthetic Cannabinoids AM-2201, CP-47,497, JWH-122, and JWH-250 by Rimonabant in Rhesus Monkeys.

Hruba L, McMahon LR. Hruba L, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):278-286. doi: 10.1124/jpet.117.240572. Epub 2017 May 22. J Pharmacol Exp Ther. 2017. PMID: 28533288 Free PMC article.

7

Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids.

Gambaro V, Arnoldi S, Bellucci S, Casagni E, Dell'Acqua L, Fumagalli L, Pallavicini M, Roda G, Rusconi C, Valoti E. Gambaro V, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:68-76. doi: 10.1016/j.jchromb.2014.03.001. Epub 2014 Mar 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. PMID: 24657413

8

Cytochrome P450-mediated metabolism of the synthetic cannabinoids UR-144 and XLR-11.

Nielsen LM, Holm NB, Olsen L, Linnet K. Nielsen LM, et al. Drug Test Anal. 2016 Aug;8(8):792-800. doi: 10.1002/dta.1860. Epub 2015 Sep 11. Drug Test Anal. 2016. PMID: 26360322

9

Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes.

Kong TY, Kim JH, Choi WG, Lee JY, Kim HS, Kim JY, In MK, Lee HS. Kong TY, et al. Anal Bioanal Chem. 2017 Feb;409(6):1667-1680. doi: 10.1007/s00216-016-0113-9. Epub 2016 Dec 6. Anal Bioanal Chem. 2017. PMID: 27924364

10

Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.

Huskey SW, Dean DC, Miller RR, Rasmusson GH, Chiu SH. Huskey SW, et al. Drug Metab Dispos. 1995 Oct;23(10):1126-35. Drug Metab Dispos. 1995. PMID: 8654202

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