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27419822,26871203,28156249,33895373,26923727,16239882,28251346,27581314,31340831,25934242,33827613,29962192,25108293,33348122,23250963,18025828,26295919,27653897,28887286,34562629,35501572,30248058,29975875,30883349,31118357,28089835,25913881,19812929,19404152,26895207,37064209,23510566,23551411,30071502,18210843,35176597,29688482,26222251,28885121,33775310,36991111,26095458,29702069,15185767,31504827,22571428,29413784,21625136,10721254,33754339,35901765,28892272,18596438,34480204,22327704,28828534,31796471,25061869,34809666,27165923,16028756,35103014,26555031,31948485,29571865,24836892,27042909,26824377,22705135,29350601,18402068,34871990,26810545,24292998,35599321,21039363,20185875,27689463,34795635,28132644,9488303,17039303,33002861,37004132,36237632,22327702,21235310,23269252,35912046,35123528,7639630,26775149,34235588,30103972,31728709,21611722,26915697,35465420,36040560,35164790,36211266,25036194,31207457,35933967,31713102,35831723,22653392,31778218,29023635,27876063,21132323,31358442,23037817,36348424,26636385,32290366,29128930,18575921,23467281,33389035,26315868,17077633,21135747,30497150,33662608,18812964,27619731,35276651,22116416,11846911,28472801,26528670,33590367,26548835,27581308,22239832,29981467,31819388,21801282,20151782,33893195,23489444,33438062,35276660,22673042,23930853,26935749,18402067,34397802,33044753,34472742,33455998,18356257,28716246,29185546,24006249,29942280,36049404,32046512,33957939,35023137,21921527,35012586,36994429,33059546,33830219,26970480,36371044,32623600,34627053,36435931,35295837,35978079,29736847,33651154,35212797,37004136,32619270,21040519,34749022,34869547,34619648,28185313,19461060,9779222,34970701,34275587,33136273,29076787,21594683,31154105,20687117,34517828,35481276,34747812,32747671,31619602,24273735,29393749,23457222,35400652,24067779,35230552,36700738,36587562,32702575,33985551,33112007,31700018,18359152,32527841,31805405,32372182,21993525,16463856,30916850,30523139,31141553,33881606,30218879,24359487,33278661,34275571,35069426,16671489,36343458,32127017,32916365,35103006,33862298,36703181,35644900,36873747,35391549,34648991,31226460,17477225,21921531,32932217,19388306,33263494,26694062,30705765,21336807,34235589,30010977,35739555,37082443,30219624,20205911,32155527,36071284,31843431,35761330,34399871,32487126,19388301,25632339,20849400,31300263,31125971,35400648,35931340,33906000,35677341,9918621,24678428,31498122,17243853,34633069,32330190,36515069,32660834,30011016,35693019,19388302,27678207,31648232,34974379,34497825,34083550,30792248,24379955,33551791,33242372,35733946,33296129,30474244,32063230,20512347,22444461,30169650,12168331,34754658,25012669,34246822,10964082,31174190,28293475,24634454,28421283,30676642,30467214,33444824,30363503,11977443,31923893,29387418,31541862,32461527,31158556,33488070,20647518,33316127,31792620,35598251,21700790,9263213,28869371,29741669,30950145,31115469,35283746,30611143,17396535,35486971,31754171,25977480,30738407,17925364,33248308,35325956,15536306,31129388,32259884,34786122,18439296,37032824,32516302,30133969,32643967,33065495,27486933,8750950,16463857,21660204,37059905,29114272,31713158,34363997,24175154,27365329,24731502,20948890,33031420,33078308,35180501,33093992,24231878,35395629,18651201,30361433,14534004,36647004,36889711,30731067,31860824,35870783,35418939,35894392,36358376,29498568,16671484,12852885,33273614,22163245,33790781,36094107,27017344,29353355,34434100,30532732,33192478,34093167,28473344,36670530,21349148,34975390,20057498,35102996,34969666,37004133,8372699,37109677,19996513,32839680,9779232,35477816,11784345,25954245,36853021,32299370,16463850,16671490,36473311,35570501,37148227,12885578,33927861,35871239,9779224,35569106,16671486,36949617,30638833,35779159,28627088,35233354,36401545,36158963,25968325,35268376,22684151,35400653,14753501,32814322,12168353,19936883,34117275,31481979,33458441,36119130,24682964,17405249,34258949,28919849,35079461,33145211,28138494,24516417,57211,17726243,32371292,31144048,33275344,31093469,33650223,9226668,22949960,18203159,25279138,34674853,26680491,32933532,29610690,23758953,35418936,16671487,35629023,32181182,22829132,25093733,34213613,35774679,35463139,36104627,31194404,30984097,36443371,21461687,27293338,34530457,31712085,19194387,31497081,33803977,34280677,33459505,34144842,30507586,36113194,35648268,25356428,34217635,36381133,10701891,28652949,33682295,34305775,22989298,36949785,25180074,33821511,35707704,34526955,33907600,30476334,30395341,33106967,33097796,34692305,32008047,31512225,35855156,28734501,33555136,36219131,29218007,583685,35080523,29302622,33862631,32938805,36704075,21526701,34484943,36908708,26719825,33234037,30682520,36623705,34621579,36204139,33839872,35976308,27330575,21325761,32164108,37047057,35572128,33875381,31622497,35774699,27790243,21327847,36422482,32959936,30584596,33906894,18728810,32160166,35735668,36561303,36799273,29279701,31838453,35345930,37024308,36248096,33371211,31336233,21516243,36923491,31043355,29180979,36188365,35707034,23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Disability risk or unimproved symptoms following shunt surgery in patients with idiopathic normal-pressure hydrocephalus: post hoc analysis of SINPHONI-2.

Yamada S, Kimura T, Jingami N, Atsuchi M, Hirai O, Tokuda T, Miyajima M, Kazui H, Mori E, Ishikawa M; SINPHONI-2 Investigators. Yamada S, et al. J Neurosurg. 2017 Jun;126(6):2002-2009. doi: 10.3171/2016.5.JNS16377. Epub 2016 Jul 15. J Neurosurg. 2017. PMID: 27419822

One-year outcome in patients with idiopathic normal-pressure hydrocephalus: comparison of lumboperitoneal shunt to ventriculoperitoneal shunt.

Miyajima M, Kazui H, Mori E, Ishikawa M; , on behalf of the SINPHONI-2 Investigators. Miyajima M, et al. J Neurosurg. 2016 Dec;125(6):1483-1492. doi: 10.3171/2015.10.JNS151894. Epub 2016 Feb 12. J Neurosurg. 2016. PMID: 26871203

Utility of MRI-based disproportionately enlarged subarachnoid space hydrocephalus scoring for predicting prognosis after surgery for idiopathic normal pressure hydrocephalus: clinical research.

Shinoda N, Hirai O, Hori S, Mikami K, Bando T, Shimo D, Kuroyama T, Kuramoto Y, Matsumoto M, Ueno Y. Shinoda N, et al. J Neurosurg. 2017 Dec;127(6):1436-1442. doi: 10.3171/2016.9.JNS161080. Epub 2017 Feb 3. J Neurosurg. 2017. PMID: 28156249

Preoperative Predictive Factors of Short-Term Outcome in Idiopathic Normal Pressure Hydrocephalus.

Kimura T, Yamada S, Sugimura T, Seki T, Miyano M, Fukuda S, Takeuchi S, Miyata S, Tucker A, Fujita T, Hashizume A, Izumi N, Kawasaki K, Nakagaki A, Sako K. Kimura T, et al. World Neurosurg. 2021 Jul;151:e399-e406. doi: 10.1016/j.wneu.2021.04.055. Epub 2021 Apr 22. World Neurosurg. 2021. PMID: 33895373

Disease duration: the key to accurate CSF tap test in iNPH.

Yamada S, Ishikawa M, Miyajima M, Atsuchi M, Kimura T, Kazui H, Mori E; SINPHONI-2 Investigators (Appendix). Yamada S, et al. Acta Neurol Scand. 2017 Feb;135(2):189-196. doi: 10.1111/ane.12580. Epub 2016 Feb 29. Acta Neurol Scand. 2017. PMID: 26923727 Clinical Trial.

Diagnosis, treatment, and analysis of long-term outcomes in idiopathic normal-pressure hydrocephalus.

McGirt MJ, Woodworth G, Coon AL, Thomas G, Williams MA, Rigamonti D. McGirt MJ, et al. Neurosurgery. 2005 Oct;57(4):699-705; discussion 699-705. doi: 10.1093/neurosurgery/57.4.699. Neurosurgery. 2005. PMID: 16239882

Cost-effectiveness analysis of shunt surgery for idiopathic normal pressure hydrocephalus based on the SINPHONI and SINPHONI-2 trials.

Kameda M, Yamada S, Atsuchi M, Kimura T, Kazui H, Miyajima M, Mori E, Ishikawa M, Date I; SINPHONI and SINPHONI-2 Investigators. Kameda M, et al. Acta Neurochir (Wien). 2017 Jun;159(6):995-1003. doi: 10.1007/s00701-017-3115-2. Epub 2017 Mar 1. Acta Neurochir (Wien). 2017. PMID: 28251346

Timing of surgical treatment for idiopathic normal pressure hydrocephalus: association between treatment delay and reduced short-term benefit.

Vakili S, Moran D, Hung A, Elder BD, Jeon L, Fialho H, Sankey EW, Jusué-Torres I, Goodwin CR, Lu J, Robison J, Rigamonti D. Vakili S, et al. Neurosurg Focus. 2016 Sep;41(3):E2. doi: 10.3171/2016.6.FOCUS16146. Neurosurg Focus. 2016. PMID: 27581314

The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients.

Junkkari A, Luikku AJ, Danner N, Jyrkkänen HK, Rauramaa T, Korhonen VE, Koivisto AM, Nerg O, Kojoukhova M, Huttunen TJ, Jääskeläinen JE, Leinonen V. Junkkari A, et al. Fluids Barriers CNS. 2019 Jul 25;16(1):21. doi: 10.1186/s12987-019-0142-9. Fluids Barriers CNS. 2019. PMID: 31340831 Free PMC article.

Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial.

Kazui H, Miyajima M, Mori E, Ishikawa M; SINPHONI-2 Investigators. Kazui H, et al. Lancet Neurol. 2015 Jun;14(6):585-94. doi: 10.1016/S1474-4422(15)00046-0. Epub 2015 Apr 28. Lancet Neurol. 2015. PMID: 25934242 Clinical Trial.

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