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Items: 1 to 20 of 97

1.

Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.

Simpson C, Jones NG, Hull-Ryde EA, Kireev D, Stashko M, Tang K, Janetka J, Wildman SA, Zuercher WJ, Schapira M, Hui R, Janzen W, Sibley LD.

ACS Infect Dis. 2016 Mar 11;2(3):194-206. Epub 2015 Dec 28.

2.

The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.

Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP.

PLoS Pathog. 2012;8(6):e1002784. doi: 10.1371/journal.ppat.1002784. Epub 2012 Jun 28.

3.

Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.

Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP.

MBio. 2015 Feb 24;6(2):e02280. doi: 10.1128/mBio.02280-14.

4.

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.

Behnke MS, Khan A, Lauron EJ, Jimah JR, Wang Q, Tolia NH, Sibley LD.

PLoS Genet. 2015 Aug 20;11(8):e1005434. doi: 10.1371/journal.pgen.1005434. eCollection 2015 Aug.

5.

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.

Fox BA, Rommereim LM, Guevara RB, Falla A, Hortua Triana MA, Sun Y, Bzik DJ.

MBio. 2016 May 10;7(3). pii: e00193-16. doi: 10.1128/mBio.00193-16.

6.

Prediction of Toxoplasma gondii virulence factor ROP18 competitive inhibitors by virtual screening.

Yin K, Zhao G, Xu C, Qiu X, Wen B, Sun H, Liu G, Liu Y, Zhao Q, Wei Q, Huang B, Yan G, Cao J.

Parasit Vectors. 2019 Mar 13;12(1):98. doi: 10.1186/s13071-019-3341-y.

7.

Toxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation.

Du J, An R, Chen L, Shen Y, Chen Y, Cheng L, Jiang Z, Zhang A, Yu L, Chu D, Shen Y, Luo Q, Chen H, Wan L, Li M, Xu X, Shen J.

J Biol Chem. 2014 May 2;289(18):12578-92. doi: 10.1074/jbc.M113.544718. Epub 2014 Mar 19.

8.

Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18.

Yamamoto M, Takeda K.

Virulence. 2012 Jan-Feb;3(1):77-80. doi: 10.4161/viru.3.1.18340. Epub 2012 Jan 1.

PMID:
22286708
9.

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.

Alaganan A, Fentress SJ, Tang K, Wang Q, Sibley LD.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1126-31. doi: 10.1073/pnas.1313501111. Epub 2014 Jan 3.

10.

The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii.

Fentress SJ, Steinfeldt T, Howard JC, Sibley LD.

Cell Microbiol. 2012 Dec;14(12):1921-33. doi: 10.1111/cmi.12022. Epub 2012 Sep 20.

11.

Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.

Fox BA, Sanders KL, Rommereim LM, Guevara RB, Bzik DJ.

PLoS Genet. 2016 Jul 22;12(7):e1006189. doi: 10.1371/journal.pgen.1006189. eCollection 2016 Jul.

12.

The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.

Behnke MS, Fentress SJ, Mashayekhi M, Li LX, Taylor GA, Sibley LD.

PLoS Pathog. 2012;8(11):e1002992. doi: 10.1371/journal.ppat.1002992. Epub 2012 Nov 8.

13.

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.

Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC.

PLoS Biol. 2010 Dec 21;8(12):e1000576. doi: 10.1371/journal.pbio.1000576. Erratum in: PLoS Biol. 2015 Jul;13(7):e1002199.

14.

ROP18 is a key factor responsible for virulence difference between Toxoplasma gondii and Neospora caninum.

Lei T, Wang H, Liu J, Nan H, Liu Q.

PLoS One. 2014 Jun 13;9(6):e99744. doi: 10.1371/journal.pone.0099744. eCollection 2014.

15.

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD.

Cell Host Microbe. 2010 Dec 16;8(6):484-95. doi: 10.1016/j.chom.2010.11.005.

16.

The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.

Hermanns T, Müller UB, Könen-Waisman S, Howard JC, Steinfeldt T.

Cell Microbiol. 2016 Feb;18(2):244-59. doi: 10.1111/cmi.12499. Epub 2015 Oct 30.

17.

Encephalitis is mediated by ROP18 of Toxoplasma gondii, a severe pathogen in AIDS patients.

An R, Tang Y, Chen L, Cai H, Lai DH, Liu K, Wan L, Gong L, Yu L, Luo Q, Shen J, Lun ZR, Ayala FJ, Du J.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5344-E5352. doi: 10.1073/pnas.1801118115. Epub 2018 May 21.

18.

The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD.

Cell Host Microbe. 2014 May 14;15(5):537-50. doi: 10.1016/j.chom.2014.04.002.

19.

ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.

Yamamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K.

J Exp Med. 2011 Jul 4;208(7):1533-46. doi: 10.1084/jem.20101660. Epub 2011 Jun 13.

20.

The ROP18 and ROP5 gene allele types are highly predictive of virulence in mice across globally distributed strains of Toxoplasma gondii.

Shwab EK, Jiang T, Pena HF, Gennari SM, Dubey JP, Su C.

Int J Parasitol. 2016 Feb;46(2):141-6. doi: 10.1016/j.ijpara.2015.10.005. Epub 2015 Dec 14.

PMID:
26699401

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