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Items: 1 to 20 of 86

1.

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG Jr.

Cell. 2016 Jun 30;166(1):126-39. doi: 10.1016/j.cell.2016.05.042.

2.

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT.

Lien EC, Ghisolfi L, Geck RC, Asara JM, Toker A.

Sci Signal. 2017 Dec 19;10(510). pii: eaao6604. doi: 10.1126/scisignal.aao6604.

3.

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells.

Hasegawa M, Takahashi H, Rajabi H, Alam M, Suzuki Y, Yin L, Tagde A, Maeda T, Hiraki M, Sukhatme VP, Kufe D.

Oncotarget. 2016 Mar 15;7(11):11756-69. doi: 10.18632/oncotarget.7598.

4.
5.

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery.

Alcaide-German ML, Vara-Vega A, Garcia-Fernandez LF, Landazuri MO, del Peso L.

BMC Cell Biol. 2008 Apr 10;9:18. doi: 10.1186/1471-2121-9-18.

6.

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

Tarhonskaya H, Hardy AP, Howe EA, Loik ND, Kramer HB, McCullagh JS, Schofield CJ, Flashman E.

J Biol Chem. 2015 Aug 7;290(32):19726-42. doi: 10.1074/jbc.M115.653014. Epub 2015 Jun 25.

7.

Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.

Singh M, Devi U, Roy S, Gupta PS, Saraf SA, Kaithwas G.

Breast Cancer. 2016 Nov;23(6):820-829. Epub 2016 Mar 7. Review.

PMID:
26951539
8.

HIF-1α triggers long-lasting glutamate excitotoxicity via system xc- in cerebral ischaemia-reperfusion.

Hsieh CH, Lin YJ, Chen WL, Huang YC, Chang CW, Cheng FC, Liu RS, Shyu WC.

J Pathol. 2017 Feb;241(3):337-349. doi: 10.1002/path.4838. Epub 2016 Dec 29.

PMID:
27801527
9.

Suppression of the xCT-CD44v antiporter system sensitizes triple-negative breast cancer cells to doxorubicin.

Wang F, Yang Y.

Breast Cancer Res Treat. 2014 Aug;147(1):203-10. doi: 10.1007/s10549-014-3068-6. Epub 2014 Aug 2. Retraction in: Breast Cancer Res Treat. 2015 Jun;151(2):479.

PMID:
25085754
10.

Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.

Hou P, Kuo CY, Cheng CT, Liou JP, Ann DK, Chen Q.

PLoS One. 2014 Nov 24;9(11):e113865. doi: 10.1371/journal.pone.0113865. eCollection 2014.

11.

The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen.

del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO.

J Biol Chem. 2003 Dec 5;278(49):48690-5. Epub 2003 Sep 23.

12.

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation.

Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH.

Sci Rep. 2016 Jan 7;6:18928. doi: 10.1038/srep18928.

13.

Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.

Snell CE, Turley H, McIntyre A, Li D, Masiero M, Schofield CJ, Gatter KC, Harris AL, Pezzella F.

PLoS One. 2014 Feb 12;9(2):e88955. doi: 10.1371/journal.pone.0088955. eCollection 2014.

14.
15.

Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.

Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4600-9. doi: 10.1073/pnas.1513433112. Epub 2015 Jul 30.

16.

β-N-oxalyl-L-α, β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions.

Eslavath RK, Sharma D, Bin Omar NAM, Chikati R, Teli MK, Rajanikant GK, Singh SS.

Eur J Pharmacol. 2016 Nov 15;791:405-411. doi: 10.1016/j.ejphar.2016.07.007. Epub 2016 Jul 5.

PMID:
27393459
17.

Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.

Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ.

J Biol Chem. 2010 Aug 27;285(35):26852-60. doi: 10.1074/jbc.M110.147041. Epub 2010 Jun 25.

18.

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.

Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F.

Cell Cycle. 2010 Sep 1;9(17):3515-33. Epub 2010 Sep 9.

19.

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.

Biochem J. 2004 Aug 1;381(Pt 3):761-7.

20.

Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1.

Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N.

Int J Cancer. 2006 Mar 1;118(5):1144-53.

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